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Pulmonary Co-delivery of DOX and siRNA
Pulmonary delivery is a noninvasive route, which can deliver drugs and therapeutic genes to pulmonary epithelia. Develo** co-delivery system for...
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Importance of the electrophoresis and pulse energy for siRNA-mediated gene silencing by electroporation in differentiated primary human myotubes
BackgroundElectrotransfection is based on application of high-voltage pulses that transiently increase membrane permeability, which enables delivery...
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Inhibition of EGFR1 in Triple Negative Breast Cancer Cells Using siRNA Loaded with Fe3O4 Magnetic Nanoparticles
Triple-negative breast cancer (TNBC) is known as the most common cancer among women in the world. Although overexpression of the EGFR1 gene is...
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Fluorinated α-Helical Polypeptides Toward Pulmonary siRNA Delivery
The mucus layer and cell membrane are two major barriers against pulmonary siRNA delivery. Commonly used polycationic gene carriers can hardly...
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siRNA Lipid–Polymer Nanoparticles Targeting E-Selectin and Cyclophilin A in Bone Marrow for Combination Multiple Myeloma Therapy
IntroductionMultiple myeloma (MM) is a hematological blood cancer of the bone marrow that remains largely incurable, in part due to its physical...
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Preparation and Evaluation of siRNAsome as siRNA and Drug Delivery System
Spherical nucleic acids (SNA) show great potential for gene regulation. However, lack of suitable SNA nanostructure to codeliver small interfering...
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Albumin-Binding Aptamer Chimeras for Improved siRNA Bioavailability
IntroductionShort interfering RNAs (siRNAs) are potent nucleic acid-based drugs designed to target disease driving genes that may otherwise be...
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Preparation and Evaluation of Rationally Designed Polymers for Efficient Endosomal Escape of siRNA
Small interfering RNA (siRNA) showed promising prospect in the fields of basic research and drug development due to its capability in inhibition of...
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Polypeptide Cationic Micelles–Mediated Co-delivery of Docetaxel and siRNA for Synergistic Tumor Therapy
The combination chemotherapy with other anticancer techniques is of great clinical importance to reduce side effects and enhance the effectiveness of...
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Pulmonary Co-delivery of DOX and siRNA
Pulmonary delivery is a noninvasive route, which can deliver drugs and therapeutic genes to pulmonary epithelia. Develo** co-delivery system for...
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Preparation and Evaluation of Polymeric Hybrid Micelles to Co-deliver Small Molecule Drug and siRNA for Rheumatoid Arthritis Therapy
Small interfering RNA (siRNA) has emerged as a potential drug candidate in the treatment of various diseases. However, efficient delivery of siRNA...
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Design of siRNA molecules for silencing of membrane glycoprotein, nucleocapsid phosphoprotein, and surface glycoprotein genes of SARS-CoV2
The global COVID-19 pandemic caused by SARS-CoV2 infected millions of people and resulted in more than 4 million deaths worldwide. Apart from...
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Fluorinated α-Helical Polypeptides Toward Pulmonary siRNA Delivery
The mucus layer and cell membrane are two major barriers against pulmonary siRNA delivery. Commonly used polycationic gene carriers can hardly...
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Preparation and Evaluation of siRNAsome as siRNA and Drug Delivery System
Spherical nucleic acids (SNA) show great potential for gene regulation. However, lack of suitable SNA nanostructure to codeliver small interfering...
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Preparation and Evaluation of Rationally Designed Polymers for Efficient Endosomal Escape of siRNA
Small interfering RNA (siRNA) showed promising prospect in the fields of basic research and drug development due to its capability in inhibition of...
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Polypeptide Cationic Micelles Mediated Co-delivery of Docetaxel and siRNA for Synergistic Tumor Therapy
The combination chemotherapy with other anticancer techniques is of great clinical importance to reduce side effects and enhance the effectiveness of...
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Preparation and Evaluation of Polymeric Hybrid Micelles to Co-Deliver Small Molecule Drug and siRNA for Rheumatoid Arthritis Therapy
Small interfering RNA (siRNA) has emerged as a potential drug candidate in the treatment of various diseases. However, efficient delivery of siRNA...
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Effects of grafting cell penetrate peptide and RGD on endocytosis and biological effects of Mg-CaPNPs-CKIP-1 siRNA carrier system in vitro
Calcium phosphate nanoparticles (CaPNPs) have good biocompatibility as gene carriers; however, CaPNPs typically exhibit a low transfection...
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Delivery of siRNA to Endothelial Cells In Vivo Using Lysine/Histidine Oligopeptide-Modified Poly(β-amino ester) Nanoparticles
PurposeEndothelial cell (EC) dysfunction underlies the pathology of multiple disease conditions including cardiovascular and pulmonary diseases....
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Preparation of Chimeric Polymersomes for Gene Delivery
RNA interference (RNAi) has become a powerful tool for the treatment of different diseases including virus infections and cancers. The clinical...