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The association of IL-17A rs2275913 single nucleotide polymorphism with anti-tuberculous drug resistance in patients with pulmonary tuberculosis
BackgroundDrug-resistant Tuberculosis (DR-TB) is a global health burden with high morbidity and mortality in develo** countries including Egypt....
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Association of the single nucleotide polymorphism in CAPN3 gene with growth performance in Merino and Garut (MEGA) backcross sheep
BackgroundSheep is one of the commodities of livestock which has been known widely in Indonesia for supporting the national food security....
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Delineating the role of single-nucleotide polymorphism of CYP19 gene on aromatase activity in South Indian women with polycystic ovary syndrome
BackgroundPolycystic ovary syndrome is a common multifactorial endocrinopathy disorder affecting 5–15% of reproductive women worldwide. The CYP19...
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Estimating the role of single-nucleotide polymorphism (rs1800629)-308 G/A of TNF-alpha gene as genetic marker associated with angina pectoris in a sample of Iraqi patients
BackgroundAngina pectoris (AP) occurs when oxygen and other nutrients are insufficient to meet the metabolic needs of the heart muscle. Stable angina...
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Contribution of glutathione peroxidase 1 (Pro200Leu) single nucleotide polymorphism and serum homocysteine levels in the risk of acute myocardial infarction in Egyptians
BackgroundOxidative stress is among the most common risk factors in the pathogenesis of acute myocardial infarction (AMI). Glutathione peroxidase 1...
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Identification of Novel Functional Single Nucleotide Polymorphisms in the BRCA1 Gene of Breast Cancer Patients
Breast cancer is the most common cancer in women, making for one-third of all malignancies in females. Between 40 and 45 percent of instances of...
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Determination of deleterious single-nucleotide polymorphisms of human LYZ C gene: an in silico study
BackgroundSingle-nucleotide polymorphisms (SNPs) have a crucial function in affecting the susceptibility of individuals to diseases and also...
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Machine learning techniques for pathogenicity prediction of non-synonymous single nucleotide polymorphisms in human body
The rapidly growing human genetic variation data resulted from high-throughput genoty** and sequencing methods has motivated bioinformaticians to...
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Single nucleotide variants of receptor for advanced glycation end-products (AGER) gene: is it a new opening in the risk assessment of diabetic retinopathy?—a review
BackgroundDiabetic retinopathy (DR) is a common microvascular complication of diabetes. There is strong evidence suggesting that DR has an...
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Polymorphism and mutational diversity of virulence (vcgCPI/vcgCPE) and resistance determinants (aac(3)-IIa, (aacC2, strA, Sul 1, and 11) among human pathogenic Vibrio species recovered from surface waters in South-Western districts of Uganda
BackgroundVibrio species are among the autochthonous bacterial populations found in surface waters and associated with various life-threatening...
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Single Cell Genomics
Single cells are the minimum physiological and biological units of tissues and organs. It is critical to isolate individual cells from tissues and...
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Whole genome sequence and comparative genomics analysis of multidrug-resistant Staphylococcus xylosus NM36 isolated from a cow with mastitis in Basrah city
BackgroundStaphylococcus xylosus is a coagulase-negative, gram-positive coccus that is found in the environment and as a commensal organism on the...
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Whole Exome Analysis to Analyse the Mutational Profiles of Taiwanese Patients with Breast Cancer
The evolution that next sequencing technologies (NGS) and computational tools have witnessed led to the discovery of analyses such as whole-exome...
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Are single nucleotide polymorphisms rs7903146 and rs12255372 in transcription factor 7-like 2 gene associated with an increased risk for gestational diabetes mellitus in Egyptian women?
BackgroundGenetic variants in the transcription factor 7-like 2 ( TCF7L2 ) gene are related with type 2 diabetes (T2D) and gestational diabetes...
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Multi-scale Algorithm and SNP Based Splice Site Prediction
In the post-genomic era, gene function prediction get more and more attention. Splice site prediction is one of the most important part of those...
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BCSNP-ML: A Novel Breast Cancer Prediction Model Base on LightGBM and Estrogen Metabolic Enzyme Genes
Estrogen-related metabolic enzyme gene polymorphisms have been demonstrated to be linked to breast cancer, and in this paper, a novel noninvasive...
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Single-Cell Technologies for Cancer Therapy
Routine sequencing techniques used in cancer diagnosis have primarily focused on bulk tissue genomic analysis. However, cell heterogeneity is a...
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IL28B rs12979860 polymorphism and zinc supplementation affect treatment outcome and liver fibrosis after direct-acting antiviral hepatitis C therapy
BackgroundImpact of interleukin 28B (IL28B) rs12979860 polymorphism on response to direct-acting antivirals agents in HCV genotype 4-infected...
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Association between polymorphisms of immune response genes and early childhood caries — systematic review, gene-based, gene cluster, and meta-analysis
BackgroundEarly childhood caries is a significant public health concern affecting about 600 million children globally. The etiology of early...
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Genetic Algorithm-Based Feature Selection and Self-Organizing Auto-Encoder (Soae) for Snp Genomics Data Classifications
SNPs (single nucleotide polymorphisms) are the most common biomarkers, and they have a wide range of applications, especially in human genetics. The...