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Design of siRNA molecules for silencing of membrane glycoprotein, nucleocapsid phosphoprotein, and surface glycoprotein genes of SARS-CoV2
The global COVID-19 pandemic caused by SARS-CoV2 infected millions of people and resulted in more than 4 million deaths worldwide. Apart from...
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Phylogenetic Study of Surface Glycoprotein (S1 Spike Protein) Sequence of SARS-CoV-2 Virus
In the recent times, the resultant pandemic of severe acute respiratory syndrome caused due to the infection of coronavirus 2 (SARS-CoV-2) accounted...
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Study of Spike Glycoprotein Motifs in Coronavirus Infecting Animals and Variants of SARS-CoV-2 Observed in Humans Across Countries
Sha, AkhbarNair, ManjushaThe greatest threat the world currently faces is due to the COVID-19 pandemic and its adverse effects. This in turn has...
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Elucidating the Inhibition Mechanism of FDA-Approved Drugs on P-glycoprotein (P-gp) Transporter by Molecular Docking Simulation
P-glycoprotein (MDR1) is an efflux transporter that regulates the elimination of the substrates, drugs, and drug metabolites from the liver into the...
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Molecular modeling of natural and synthesized inhibitors against SARS-CoV-2 spike glycoprotein
PurposeViral diseases increasingly endanger the world public health because of the transient efficacy of antiviral therapies. The novel coronavirus...
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Andrographolide binds to spike glycoprotein and RNA-dependent RNA polymerase (NSP12) of SARS-CoV-2 by in silico approach: a probable molecule in the development of anti-coronaviral drug
The SARS-CoV-2 belongs to Coronaviridae family infects host cells by the interaction of its spike glycoprotein and angiotensin-converting enzyme 2...
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Immobilization of Anti-hCG Antibody to Nitrocellulose via Protein G
Recently, biosensors have been widely studied and applied in disease diagnosis. Many factors affect the sensitivity of biosensors, two of which are...
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A multi-population-based genomic analysis uncovers unique haplotype variants and crucial mutant genes in SARS-CoV-2
BackgroundCOVID-19 is a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Rigorous detection and treatment strategies...
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Analysing the impact of the two most common SARS-CoV-2 nucleocapsid protein variants on interactions with membrane protein in silico
As the body of scientific research focusing on the severe acute respiratory syndrome coronavirus 2 or SARS-CoV-2 continues to grow, several mutations...
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Mathematical Modeling of the Effects of anti-CD147 Drug on Tumor Angiogenesis
Angiogenesis is an essential process for the growth of a tumor. Also, angiogenesis is mostly responsible for the spreading (metastasis) of cancer....
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Bioorthogonal Engineered Virus-Like Nanoparticles for Efficient Gene Therapy
Gene therapy offers potentially transformative strategies for major human diseases. However, one of the key challenges in gene therapy is develo**...
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Pregnancy-Associated Proteins as a Tool in the Therapy of Autoimmune Diseases and Alloimmune Disorders (Review)
From the point of view of reproductive immunology, pregnancy is the only physiological phenomenon in which the immune system, recognizing fetal...
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Molecular docking and simulation investigation: effect of beta-sesquiphellandrene with ionic integration on SARS-CoV2 and SFTS viruses
BackgroundAt present, viral diseases become major concern for the world. SARS-CoV2 and SFTS viruses are deadly in nature, and there is a need for...
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SARS-CoV-2 spike and ACE2 entanglement-like binding
We describe the binding between the glycoprotein Spike of SARS-CoV-2 and the human host cell receptor ACE2 as a quantum circuit, comprising the...
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Preparation and Evaluation of siRNAsome as siRNA and Drug Delivery System
Spherical nucleic acids (SNA) show great potential for gene regulation. However, lack of suitable SNA nanostructure to codeliver small interfering...
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Cell Membrane Coating Technology: A Promising Strategy for Biomedical Applications
Cell membrane coating technology is an approach to the biomimetic replication of cell membrane properties, and is an active area of ongoing research...
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Amelotin Promotes Mineralization and Adhesion in Collagen-Based Systems
IntroductionPeriodontitis is characterized by the destruction of tooth-supporting tissues including the alveolar bone. Barrier membranes are used in...
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Influence of Substrate Stiffness on Barrier Function in an iPSC-Derived In Vitro Blood-Brain Barrier Model
IntroductionVascular endothelial cells respond to a variety of biophysical cues such as shear stress and substrate stiffness. In peripheral...
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Free Radical Scavenger Activity and P-glycoprotein Inhibition Capacity of 1,2,4-Trihydroxyxanthone
Some xanthone derivatives isolated from plants possess antifungal, antimicrobial, antioxidative and cytotoxic activities. Therefore, products...