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A Model for Chemomechanical Coupling of Kinesin-3 Motor
IntroductionKinesin-3 motor, which is in the monomeric and inactive form in solution, after cargo-induced dimerization can step on microtubules...
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Characterizing the Number of Kinesin Motors Bound to Microtubules in the Gliding Motility Assay Using FLIC Microscopy
Intracellular transport by kinesin motors moving along their associated cytoskeletal filaments, microtubules, is essential to many biological...
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Linear-Zero Mode Waveguides for Single-Molecule Fluorescence Observation of Nucleotides in Kinesin-Microtubule Motility Assay
Single-molecule fluorescence microscopy is a key tool to investigate the chemo-mechanical coupling of microtubule-associated motor proteins, such as...
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Dynamic Pattern Formation of Active Matters Triggered by Mechanical Stimuli
In vitro gliding assay of the filamentous protein microtubule (MT) on a kinesin motor protein coated surface has appeared as a classic platform for...
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Microtubules and Quantum Dots Integration Leads to Conjugates with Applications in Biosensors and Bionanodevices
This chapter describes compiled methods for the formation and manipulation of microtubule-kinesin-carbon nanodots conjugates in user-defined...
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Fabrication of Artificial Muscle from Microtubules, Kinesins, and DNA Origami Nanostructures
Fabrication of molecular devices using biomolecules through biomimetic approaches has witnessed a surge in interest in recent years. DNA a versatile...
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Shaft Function of Kinesin-1’s α4 Helix in the Processive Movement
IntroductionKinesin-1 motor is a molecular walking machine constructed with amino acids. The understanding of how those structural elements play...
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Mechanistic progression of acrylamide neurotoxicity linked to neurodegeneration and mitigation strategies
Acrylamide (AA) is a potential neurotoxic chemical used widely in numerous large-scale industries and molecular research labs. It is a common toxic...
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Assembling Microtubule-Based Active Matter
Studied for more than a century, equilibrium liquid crystals provided insight into the properties of ordered materials, and led to commonplace...
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Mechanical Deformation of Microtubules on a Two-Dimensional Elastic Medium
Microtubule, the most rigid filamentous protein in cytoskeleton, plays significant roles in cellular mechano-transduction and mechano-regulation of...
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Spontaneously Beating Biomimetic Structures
The propulsion of motile cells such as sperms and the transport of fluids on cell surfaces rely on oscillatory bending of cellular appendages that...
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Effect of KIF15 as a promoter role in the progression of osteosarcoma based on TCGA database
Osteosarcoma has been the widely occurred primary malignant tumors of bone in children and adolescents. Emerging reports have revealed that it is one...
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Facile Method of Tubulin Purification from Goat Brain for Reconstitution of Microtubule-Associated Intracellular Function
Tubulin/microtubule plays crucial role in eukaryotic cell division. Polymerization of αβ-tubulin heterodimers forms the microtubules, which is...
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Proteins: The Basis of Biological Mechanisms
Proteins are one of the most important building blocks for the achievement of the numerous biological reactions that occur every day in our body. The...
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Protein Vibrations and Conformational Changes
We mentioned in Chapter 2 that proteins are not static entities, but flexible macromolecules able to change their three-dimensional conformation...
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Collective Molecular Machines: Multidimensionality and Reconfigurability
Molecular machines are key to cellular activity where they are involved in converting chemical and light energy into efficient mechanical work....
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Unravelling the mechanotransduction pathways in Alzheimer’s disease
Alzheimer’s disease (AD) represents one of the most common and debilitating neurodegenerative disorders. By the end of 2040, AD patients might reach...
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Construction of Molecular Robots from Microtubules for Programmable Swarming
Swarm robotics has been attracting much attention in recent years in the field of robotics. This chapter describes a methodology for the construction...
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Cargo Transport by Microtubule-Associated Motor Protein Along Mechanically Deformed Microtubules
Mechanical forces play pivotal roles in regulating various cellular functions. Biomolecular motor protein-driven intracellular transportation is one...
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Reconstituting the Interaction Between Purified Nuclei and Microtubule Network
The nucleus is the stiffest organelle in the cell. Several morphogenetic processes depend on its deformation such as cell migration, cell...