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Dynamic Transcriptional Programs During Single NK Cell Killing: Connecting Form to Function in Cellular Immunotherapy
IntroductionNatural killer (NK) cell-based therapies are a promising new method for treating indolent cancer, however engineering new therapies is...
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Current standards and the future role of hadrontherapy in the treatment of central nervous system tumors
IntroductionRadiation therapy is vital for treating central nervous system cancers (CNS), but traditional methods have limitations, especially in...
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Green Synthesis of Silver Nanoparticles Using Penicillium camemberti and its Biological Applications
Silver nanoparticles (AgNPs) prepared through biological means have gained tremendous emphasis particularly, for biomedical applications. In this...
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Ventral tegmental area deep brain stimulation reverses ethanol-induced dopamine increase in the rat nucleus accumbens
The neurophysiology of alcohol use disorder (AUD) is complex, but a major contributor to addictive phenotypes is the tendency for drugs of abuse to...
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A computational study of the influence of thyroarytenoid and cricothyroid muscle interaction on vocal fold dynamics in an MRI-based human laryngeal model
A human laryngeal model, incorporating all the cartilages and the intrinsic muscles, was reconstructed based on MRI data. The vocal fold was...
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Doxorubicin and Curcumin-Loaded Nanomicelles Targeting Multidrug Resistance in Cancer
Multidrug resistance (MDR) poses a significant challenge in cancer therapeutics, particularly in breast cancer treatment. This study emphasizes the...
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A thematic analysis of ransomware incidents among United States hospitals, 2016–2022
PurposeTo characterize the patterns, vulnerabilities, and responses associated with ransomware incidents in U.S. hospitals.
MethodsThe study employs...
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Biological Properties of Mycosynthesized Novel Strontium Oxide Nanoparticles from Biomass Free Filtrate of Endophytic Fungus Aspergillus sp. LCJ315
Rising global mortality rates due to antimicrobial infections and cancer underscore the urgent need for effective therapeutic interventions. Here, we...
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Probing the Effects of Chirality on Self-Assembling Peptides: Hydrogel Formation, Degradation, Antigen Release, and Adjuvancy
IntroductionMultidomain peptides (MDPs) are amino acid sequences that self-assemble to form supramolecular hydrogels under physiological conditions...
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Magnetoactive, Kirigami-Inspired Hammocks to Probe Lung Epithelial Cell Function
IntroductionMechanical forces provide critical biological signals to cells. Within the distal lung, tensile forces act across the basement membrane...
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Toward a physiological model of vascular wall vibrations in the arteriovenous fistula
The mechanism behind hemodialysis arteriovenous fistula (AVF) failure remains poorly understood, despite previous efforts to correlate altered...
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Modelling the rheology of living cell cytoplasm: poroviscoelasticity and fluid-to-solid transition
Eukaryotic cell rheology has important consequences for vital processes such as adhesion, migration, and differentiation. Experiments indicate that...
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In-Vitro, Ex-Vivo & In-Vivo Assessment of Brain Targeted Thermoreversible Mucoadhesive In-Situ Intranasal Gel of Carmustine for the Treatment of Glioblastoma
The goal of the present study was to prepare an in situ carmustine gel to evaluate the viability of brain targeting via nasal administration. Initial...
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Sustained Release of Chemical Fertiliser by Nanochitosan: Insights and Updates
Controlled-release fertilisers are granular particles coated with a polymer that can release nutrients over a long time by preventing moisture...
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Exploring the Green Power Unleashed by ZnO-Immobilized Aspergillus oryzae Cutinase for the Degradation of Insecticide and Polyester Waste
The present study deals with the enhanced production of cutinase (E.C. 3.1.1.74) by Aspergillus oryzae ISL-9 under submerged fermentation and its...
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Modeling the mechanosensitive collective migration of cells on the surface and the interior of morphing soft tissues
Cellular contractility, migration, and extracellular matrix (ECM) mechanics are critical for a wide range of biological processes including embryonic...
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Computational analysis on 3D airway model of obstructive sleep apnea patient for optimal maxillomandibular advancement
Obstructive sleep apnea (OSA) can have many adverse effects on people’s health, including cognitive decline and high blood pressure. Typical surgical...
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Nanotechnology as an Emerging Innovation: Sources, Application in a Sustainable Agriculture and Environmental Analysis
The growing world population and the increasing burden on the agricultural sector to meet the associated increased food demand are major concerns of...
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A mechanics theory for the exploration of a high-throughput, sterile 3D in vitro traumatic brain injury model
Brain injuries resulting from mechanical trauma represent an ongoing global public health issue. Several in vitro and in vivo models for traumatic...
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Numerical Simulation of Bioconvection Maxwell Nanofluid Flow due to Stretching/Shrinking Cylinder with Gyrotactic Motile Microorganisms: A Biofuel Applications
The bioconvection effects with nanofluid are major application in biofuels. This analysis aimed to observe the bioconvection effect in unsteady...
