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Fibrogenic Factors and Molecular Mechanisms
Transforming growth factor-β is the major factor that influences fibroblast activation, extracellular matrix production, and other aspects important...
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PTHrP promotes subchondral bone formation in TMJ-OA
PTH-related peptide (PTHrP) improves the bone marrow micro-environment to activate the bone-remodelling, but the coordinated regulation of PTHrP and...
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Biomarkers in Oral Submucous Fibrosis
Initiation and progression of oral submucous fibrosis (OSF) and its transformation to oral squamous cell carcinoma (OSCC) involve changes at the...
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Stromal thrombospondin 1 suppresses angiogenesis in oral submucous fibrosis
A decline in mucosal vascularity is a histological hallmark of oral submucous fibrosis (OSF), a premalignant disease that is largely induced by betel...
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Specific RNA m6A modification sites in bone marrow mesenchymal stem cells from the jawbone marrow of type 2 diabetes patients with dental implant failure
The failure rate of dental implantation in patients with well-controlled type 2 diabetes mellitus (T2DM) is higher than that in non-diabetic...
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RNAseq of TGF-β receptor type I kinase-dependent genes in oral fibroblast exposed to milk
BackgroundMilk is a rich source of natural growth factors that may support oral tissue homeostasis and wound healing. We had shown earlier that...
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Roles of extracellular adenosine triphosphate on the functions of periodontal ligament cells
ObjectiveAdenosine triphosphate (ATP) is an essential nucleotide that is normally present in both intracellular and extracellular compartments....
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Depletion of EREG enhances the osteo/dentinogenic differentiation ability of dental pulp stem cells via the p38 MAPK and Erk pathways in an inflammatory microenvironment
BackgroundEpiregulin (EREG) is an important component of EGF and was demonstrated to promote the osteo/dentinogenic differentiation of stem cells...
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Attenuation of orthodontically induced inflammatory root resorption by using low-intensity pulsed ultrasound as a therapeutic modality- a systematic review
Ultrasound is an effective tool for both diagnostic and therapeutic applications. As an imaging tool, ultrasound has mostly been used for real-time...
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Regenerative Approaches in Oral and Maxillofacial Surgery
The ultimate goal for an oral and maxillofacial surgeon is to recover normal function and reach satisfying aesthetic results. The nature of surgical...
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Spatial signalling mediated by the transforming growth factor-β signalling pathway during tooth formation
Tooth development relies on sequential and reciprocal interactions between the epithelial and mesenchymal tissues, and it is continuously regulated...
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Craniofacial therapy: advanced local therapies from nano-engineered titanium implants to treat craniofacial conditions
Nano-engineering-based tissue regeneration and local therapeutic delivery strategies show significant potential to reduce the health and economic...
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Molecular and Signaling Pathways During Oral Carcinogenesis
Oral carcinogenesis is a consequence of multiple alterations in important pathways of a cell’s life. These altered pathways provide capabilities to...
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Regenerative Approaches in Oral Medicine
Stem cells are undifferentiated cells, which possess self-renewal properties and can produce specialized cells of multiple lineages. In addition to...
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Mechanoresponsive and lubricating changes of mandibular condylar cartilage associated with mandibular lateral shift and recovery in the growing rat
ObjectiveThe in vivo mechanoresponsive and lubricating changes of the mandibular condylar cartilage (MCC) associated with mandibular lateral shift...
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Regenerative Approaches in Periodontics
Developments in engineering and biological science technologies in recent years have increased the capacity of tissue engineering to be utilized in...
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Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation
The integrity of the basal stem cell layer is critical for epithelial homoeostasis. In this paper, we review the expression of oral mucosal stem cell...
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BMP4-regulated human dental pulp stromal cells promote pulp-like tissue regeneration in a decellularized dental pulp matrix scaffold
Pulp regeneration with stem cells is a promising alternative for treating periapical and pulp diseases of young permanent teeth. The aim of this...
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Immune checkpoint pathways in immunotherapy for head and neck squamous cell carcinoma
With the understanding of the complex interaction between the tumour microenvironment and immunotherapy, there is increasing interest in the role of...
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Gap junction-mediated cell-to-cell communication in oral development and oral diseases: a concise review of research progress
Homoeostasis depends on the close connection and intimate molecular exchange between extracellular, intracellular and intercellular networks....
