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Adiponectin inhibits ROS/NLRP3 inflammatory pathway through FOXO3A to ameliorate oral submucosal fibrosis
Oral submucous fibrosis (OSF) is an oral condition characterized by chronic progression, which may lead to the development of malignancy. Currently,...
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Fibrogenic Factors and Molecular Mechanisms
Transforming growth factor-β is the major factor that influences fibroblast activation, extracellular matrix production, and other aspects important... -
Curcumin as a Chemopreventive Agent for Oral Submucous Fibrosis
It is well known that there are no efficacious prevention and treatment strategies available for OSF. However, accumulating line of evidence suggests... -
In Vivo and In Vitro Experimental Evidence
This chapter deals with experimental evidence of known risk factors in creating an environment conducive for the development of oral submucous... -
Biomarkers in Oral Submucous Fibrosis
Initiation and progression of oral submucous fibrosis (OSF) and its transformation to oral squamous cell carcinoma (OSCC) involve changes at the... -
Coexpression network analysis identified MT3 as a hub gene that promotes the chemoresistance of oral cancer by regulating the expression of YAP1
BackgroundOral cancer is considered one of the most malignant types of tumors and is known for its high likelihood of recurrence and metastasis....
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Genetic Aspects of Oral Submucous Fibrosis
Oral cancer is a multistep process which may be preceded by oral potentially malignant disorders (OPMDs), such as oral submucous fibrosis (OSF) [1].... -
World Literature: Bibliography
There has been considerable research interest in oral submucous fibrosis in the past few decades. These essentially relate to epidemiological... -
Identification of novel fibroblast-like cells from stem cells from human exfoliated deciduous teeth
ObjectivesThis study aimed to differentiate and characterize fibroblast-like cells from stem cells from human exfoliated deciduous teeth (SHED).
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Drug-Induced Gingival Overgrowth
Gingival enlargement is characterized by an increase in the volume of gingival tissues that can be aggravated by local factors. Many drugs are known... -
Temporal gene expression profiling during early-stage traumatic temporomandibular joint bony ankylosis in a sheep model
BackgroundInvestigating the molecular biology underpinning the early-stage of traumatic temporomandibular joint (TMJ) ankylosis is crucial for...
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Applications of 3D Printing in Periodontal Tissue Regeneration
The use of 3D printing for periodontal regeneration is still in its infancy. Thorough knowledge of the biological mechanisms and 3D printing systems... -
Single-cell transcriptomic analysis uncovers the origin and intratumoral heterogeneity of parotid pleomorphic adenoma
Pleomorphic adenoma (PA) is the most common benign tumour in the salivary gland and has high morphological complexity. However, the origin and...
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RNAseq of TGF-β receptor type I kinase-dependent genes in oral fibroblast exposed to milk
BackgroundMilk is a rich source of natural growth factors that may support oral tissue homeostasis and wound healing. We had shown earlier that...
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Role of hyaluronan in regulating self-renewal and osteogenic differentiation of mesenchymal stromal cells and pre-osteoblasts
ObjectivesThe aim of the study was to investigate the impact of two hyaluronan (HA) formulations on the osteogenic potential of osteoblast precursors.
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Label-free quantitative proteomics reveals molecular correlates of altered biomechanical properties in molar incisor hypomineralization (MIH): an in vitro study
PurposeMolar-incisor hypomineralization (MIH) is a qualitative developmental defect of enamel that affects first permanent molars with or without...
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Regenerative Approaches in Oral Medicine
Stem cells are undifferentiated cells, which possess self-renewal properties and can produce specialized cells of multiple lineages. In addition to... -
Loss of oral mucosal stem cell markers in oral submucous fibrosis and their reactivation in malignant transformation
The integrity of the basal stem cell layer is critical for epithelial homoeostasis. In this paper, we review the expression of oral mucosal stem cell...
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4-Hexylresorcinol induced angiogenesis potential in human endothelial cells
Background4-Hexylresorcinol (4HR) is able to increase angiogenesis. However, its molecular mechanism in the human endothelial cells has not been...
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Disrupted tenogenesis in masseter as a potential cause of micrognathia
Micrognathia is a severe craniofacial deformity affecting appearance and survival. Previous studies revealed that multiple factors involved in the...