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Uterine luminal-derived extracellular vesicles: potential nanomaterials to improve embryo implantation
Most pregnancy losses worldwide are caused by implantation failure for which there is a lack of effective therapeutics. Extracellular vesicles are...
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Continuous artificial light potentially disrupts central and peripheral reproductive clocks leading to altered uterine physiology and reduced pregnancy success in albino mice
AimsThe mechanism behind clock coordination in female reproductive disorders is poorly understood despite the known importance of coordinated and...
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Protein Delivery and Mimicry
The multiple examples of the strategiesConjugation of the use of CPPs to shuttle the proteinsComplexation and protein mimicsProtein mimic and their...
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Structure-based drug design and molecular dynamics studies of an allosteric modulator targeting the protein–protein interaction site of PDK1
ContextProtein–protein interaction interfaces play a major role in cell signaling pathways. There is always a great interest in develo**...
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LncRNA VPS9D1-AS1 Sponging miR-520a-5p Contributes to the Development of Uterine Corpus Endometrial Carcinoma by Enhancing BIRC5 Expression
The pattern of VPS9D1-AS1 expression and its effects on uterine corpus endometrial carcinoma (UCEC) remained unclear. VPS9D1-AS1, miR-520a-5p, and...
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The function role and synergic effect of syndecan-1 for mifepristone in uterine leiomyoma
The study intends to investigate the regulation of syndecan-1 in human uterine leiomyoma cells. Human syndecan-1 levels were detected by Western blot...
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Effect of maternal curcumin supplementation on intestinal damage and the gut microbiota in male mice offspring with intra-uterine growth retardation
PurposeThe present study investigated whether maternal curcumin supplementation might protect against intra-uterine growth retardation (IUGR) induced...
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Uterine macrophages as treatment targets for therapy of premature rupture of membranes by modified ADSC-EVs through a circRNA/miRNA/NF-κB pathway
BackgroundCircular RNA (circRNA) is a type of stable non-coding RNA that modifies macrophage inflammation by sponging micro RNAs (miRNAs), binding to...
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Increased Immune Infiltration and Improved Prognosis of Head and Neck Squamous Cell Carcinoma Associated with Reduced Ancient Ubiquitous Protein 1 Gene Expression
This study aimed to explore the molecular mechanism underlying the prognostic role of ancient ubiquitous protein 1 (AUP1) in head and neck squamous...
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Uterine metabolic disorder induced by silica nanoparticles: biodistribution and bioactivity revealed by labeling with FITC
Extensive application of nanomaterials has dramatically increased the risk of silica nanoparticle (SiNP, SiO 2 ) exposure, yet their biological effect...
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Heat shock protein paradigms in cancer progression: future therapeutic perspectives
Heat-shock proteins (HSPs), also known as stress proteins, are ubiquitously present in all forms of life. They play pivotal roles in protein folding...
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Ultrasound Assisted Synthesis of Starch-green Tea Extract Composite and its Therapeutic Effects on Adenomyosis by Following the MAPK/ERK Signaling and Pro-inflammatory Pathways in Mice
A unique starch-green tea extract composite was synthesized following a bio-inspired ‘green’ method under ultrasonication. The polar hydroxyl...
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Protein Mimicry and the Design of Bioactive Cell-Penetrating Peptides: The Genesis of STOPSPERM Bioportides
The mature spermatozoon, a highly differentiated cell equipped for the sole purpose of fertilization, lacks the protein machinery required for...
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Exploring the therapeutic effect of Pen Yan Kang Fu Decoction on SPID rats based on LIF/JAK2/STAT3 signaling pathway
Tubal inflammation, endometritis, and uterine adhesions due to post-pelvic inflammatory disease (SPID) are important causes of infertility. Chronic...
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Analytical method development for exploring pharmacokinetic profile of ursolic acid in rat tissues by high-performance thin-layer chromatography
A simple and rapid high-performance thin-layer chromatographic (HPTLC) determination of ursolic acid (UA) in tissue is necessary for its utilization...
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Dual-drug-loaded MSCs-derived exosomal vesicles inhibit endometrial cancer cell proliferation by promoting apoptosis through the migration and invasion of Rac1/NF-κB/MMP2 signalling pathway
AbstractEndometrial carcinoma affects the uterine lining. Endogenous activity, intrinsic targeting, and ability to engage with a host defence system...
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Metabolic Profiling of Carboxylic Acids and Amino Acids in the Biological Fluids of Patients Diagnosed with Endometriosis Using Liquid (HPLC-UV) and Gas (GC–MS) Chromatography
AbstractApproaches to the highly sensitive determination of low-molecular-weight fatty acids and amino acids in blood serum samples of patients...
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Comprehensive Study of Human FBXW7 Deleterious nsSNP’s Functional Inference and Susceptibility to Gynaecological Cancer
Cancer is one of the world’s major causes of mortality, and it plays a most important role in the world’s declining life expectancy. F-box and WD-40...
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Optimizing the Expression and Solubilization of an E. coli-Produced Leukemia Inhibitory Factor for Anti-LIF Antibody Production and Use Thereof for Contraception in Mice
Leukemia inhibitory factor (LIF) is an essential cytokine for blastocyst implantation. This study evaluated the effect of LIF inhibition on the...
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Noncanonical Amino Acid Incorporation in Mice
Genetic code expansion enables in cellulo biosynthesis of curative proteins with enhanced specificity, improved stability, and even novel functions,...