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Discovery of dual rho-associated protein kinase 1 (ROCK1)/apoptosis signal–regulating kinase 1 (ASK1) inhibitors as a novel approach for non-alcoholic steatohepatitis (NASH) treatment
In the current study we suggest a novel approach to curb non-alcoholic steatohepatitis (NASH) progression, and we suggest privileged scaffolds for...
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Structural and molecular dynamics simulation studies of CBL-interacting protein kinase CIPK and its complexes related to plant salinity stress
ContextCalcium-dependent signaling in plants is responsible for several major cellular events, including the activation of the salinity-responsive...
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Analysis of a Novel Peptide That Is Capable of Inhibiting the Enzymatic Activity of the Protein Kinase A Catalytic Subunit-Like Protein from Trypanosoma equiperdum
A 26-residue peptide possessing the αN-helix motif of the protein kinase A (PKA) regulatory subunit-like proteins from the Trypanozoom subgenera...
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Unveiling Potential Targeted Therapeutic Opportunities for Co-Overexpressed Targeting Protein for Xklp2 and Aurora-A Kinase in Lung Adenocarcinoma
Lung adenocarcinoma (LUAD) is one of the most prevalent and leading causes of cancer deaths globally, with limited diagnostic and clinically...
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Characterization of putative calcium-dependent protein kinase-1 (TaCPK-1) gene: hubs in signalling and tolerance network of wheat under terminal heat
Calcium-dependent protein kinase (CDPK) is member of one of the most important signalling cascades operating inside the plant system due to its...
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Targeted Profiling of Protein Phosphorylation in Plants
Proteins are crucial for controlling different cellular processes by perceiving and converting external environmental cues into cellular responses....
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Selective Inhibition of Kinase Activity in Mammalian Cells by Bioorthogonal Ligand Tethering
Enzymes are critical for cellular functions, and malfunction of enzymes is closely related to many human diseases. Inhibition studies can help in...
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Self-Association of Phosphorylase Kinase under Molecular Crowding Conditions
Self-association of phosphorylase kinase (PhK) has been studied using analytical ultracentrifugation and dynamic light scattering under the...
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Pharmacophore modeling, docking and molecular dynamics simulation for identification of novel human protein kinase C beta (PKCβ) inhibitors
Protein kinase Cβ (PKCβ) is considered as an attractive molecular target for the treatment of COVID-19-related acute respiratory distress syndrome...
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Kinase-Catalyzed Biotinylation to Identify Phosphatase Substrates (K-BIPS)
Phosphorylation is a reversible post-translational modification that alters the functions of proteins to govern various cellular events, including...
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Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors
Medicinal chemistry has discovered thousands of potent protein and lipid kinase inhibitors. These may be developed into therapeutic drugs or chemical...
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Identification of the Beta Subunit Fas1p of Fatty Acid Synthetase as an Interacting Partner of Yeast Calcium/Calmodulin-Dependent Protein Kinase Cmk2p Through Mass Spectrometry Analysis
The calcium/calmodulin-dependent protein kinase II (CaMKII) is a mediator of calcium signals and regulates fatty acid metabolism in mammalian cells....
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Meta-learning-based Inductive logistic matrix completion for prediction of kinase inhibitors
AbstractProtein kinases become an important source of potential drug targets. Develo** new, efficient, and safe small-molecule kinase inhibitors...
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DeKinomics pulse-chases kinase functions in living cells
Cellular context is crucial for understanding the complex and dynamic kinase functions in health and disease. Systematic dissection of...
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Molecular dynamic investigation for Roco4 kinase inhibitor as treatment options for parkinsonism
ContextParkinson's disease is a neurodegenerative condition characterized by the degeneration of dopaminergic neurons, resulting in motor...
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Lacticaseibacillus casei K11 exerts immunomodulatory effects by enhancing natural killer cell cytotoxicity via the extracellular regulated-protein kinase pathway
PurposeProbiotics can serve as immunomodulators that regulate the activation of immune cells. This study aimed to screen potential probiotic strains...
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Resveratrol butyrate esters inhibit lipid biosynthesis in 3T3-L1 cells by AMP-activated protein kinase phosphorylation
Resveratrol butyrate esters (RBEs), which are novel resveratrol-synthesized derivatives, exhibit increased biological activity. This study elucidated...
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Protein Kinases and their Inhibitors Implications in Modulating Disease Progression
Protein phosphorylation plays an important role in cellular pathways, including cell cycle regulation, metabolism, differentiation and survival. The...
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Detecting PTP Protein–Protein Interactions by Fluorescent Immunoprecipitation Analysis (FIPA)
Identifying protein–protein interactions is crucial for revealing protein functions and characterizing cellular processes. Manipulating PPIs has...
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Cyclic AMP Responsive Element Binding Protein 3-like 4/AarF Domain Containing Kinase 5 Axis Facilitates Proliferation, Migration and Invasion of Lung Adenocarcinoma Cells by Modulating the TGFβ Pathway
Cyclic AMP responsive element binding protein 3-like 4 (CREB3L4) has been reported as a transcription factor showing high expression in various...