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Screening and genetic engineering of marine-derived Aspergillus terreus for high-efficient production of lovastatin
BackgroundLovastatin has widespread applications thanks to its multiple pharmacological effects. Fermentation by filamentous fungi represents the...
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Performance and mechanism of co-culture of Monascus purpureus, Lacticaseibacillus casei, and Saccharomyces cerevisiae to enhance lovastatin production and lipid-lowering effects
To facilitate lipid-lowering effects, a lovastatin-producing microbial co-culture system (LPMCS) was constituted with a novel strain Monascus purpureus ...
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Lovastatin production by an oleaginous fungus, Aspergillus terreus KPR12 using sago processing wastewater (SWW)
BackgroundLovastatin is one of the first statins to be extensively used for its cholesterol-lowering ability. It is commercially produced by...
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Increasing Lovastatin Production by Re-routing the Precursors Flow of Aspergillus terreus via Metabolic Engineering
Lovastatin is an anti-cholesterol medicine that is commonly prescribed to manage cholesterol levels, and minimise the risk of suffering from...
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Preparation and Characterization of Chitosan/Fish Scale Collagen/Lovastatin Nanocomposites
In this study, a polymeric drug delivery system based on chitosan and fish scale collagen was fabricated in the nanometer size by the emulsification...
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Fruiting bodies of selected edible mushrooms as a potential source of lovastatin
Agaricus bisporus , Cantharellus cibarius , Imleria badia , and Lentinula edodes are among the most popular species of edible mushrooms in Poland. These...
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Molecular and Computational Analysis Identify Statins as Selective Inhibitors of Human Butyrylcholinesterase
Cholinesterase enzyme family consists of acetylcholinesterase (AChE, 3.1.1.7), the major enzyme responsible for hydrolysis of acetylcholine at...
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Effect of Both Lovastatin and Ginsenoside Rb1 on Some Properties and In-Vitro Drug Release of Alginate/Chitosan/Lovastatin/Ginsenoside Rb1 Composite Films
This article reports the interactions between lovastatin—a drug for treatment of reducing cholesterol and ginsenoside Rb1—a active substance...
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Lovastatin in lactone and hydroxy acid forms and citrinin in red yeast rice powders analyzed by HPTLC-UV/FLD
For the analysis of pigment-rich red yeast rice products, a fast quantitative high-performance thin-layer chromatography (HPTLC) method was newly...
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Comparison of lovastatin, citrinin and pigment production of different Monascus purpureus strains grown on rice and millet
Six Monascus purpureus (red mould) strains were cultivated on brown rice and millet as substrates. They underwent strain selection for high...
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Assessment of the thermal and oxidative stability of Antrodia salmonea extract in drip** pills via DSC and TAM air analyses
Lovastatin, also known as monacolin K, is the major active component in red yeast rice. It is the principal active substance in Monascus fermentation...
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Influence of the construction of porous spargers on lovastatin production by Aspergillus terreus ATCC 20,542 in a laboratory bubble column
In bubble column bioreactors, the hydrodynamic behavior like mixing time, bubble size and morphology of filamentous fungi are influenced by the...
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Fully automated method based on on-line molecularly imprinted polymer solid-phase extraction for determination of lovastatin in dietary supplements containing red yeast rice
A fully automated method for the determination of lovastatin in dietary supplements containing red yeast rice has been developed. It uses a...
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Bioprospecting lovastatin production from a novel producer Cunninghamella blakesleeana
Beside anti-cholesterol activity, lovastatin garners worldwide attention for therapeutical application against various diseases especially cancer. A...
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Improved methanol-derived lovastatin production through enhancement of the biosynthetic pathway and intracellular lovastatin efflux in methylotrophic yeast
BackgroundMethanol has attracted interest as a substrate for improvement of product titers and yields of bioprocesses, because methanol has a more...
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Natural products ameliorating the adverse health effects by air particulate matter
The threats of air pollution mediated by particulate matter (PM) to human health are severe burdens to modern society. For example, PM is inhaled in...
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Mycosterols
Sterols are amphipathic lipids that play essential roles in the physiology of eukaryotic organisms in general. The fungal sterols are collectively...
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Biochemistry of Secondary Metabolism of Fungi
Fungi, eukaryotic organisms with a kingdom of their own, include microorganisms from moulds and yeasts to the most known and appreciated mushrooms....
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New Trends from Fungi Secondary Metabolism in the Pharmaceutical Industry
Fungi are eukaryotic organisms that can produce a wide range of secondary metabolites with a significant impact on society. Some metabolites are...
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Safety evaluation of mycotoxin citrinin production from Monascus ruber through whole-genome sequencing and analytical evaluation
In this study, the whole genome of Monascus ruber KACC 46666 was generated using the PacBio RSII sequencer with high-quality de novo assembly to...
