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Synthesis and Properties of New Conjugates of Isatin and Bicyclic Monoterpenes
AbstractConjugates of isatin and hydrazones based on (+)-camphor and (–)-fenchone were synthesized for the first time. The physicochemical properties...
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An oxidative expansion mechanism of isatin-derived imines
Sodium borohydride induces the oxidative expansion of the imine derived from isatin and phenylethylamine to form 3-phenethylquinazoline-2,4(1 H ,3 H )-dio...
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Relationship Between the Volume of Benzyl Substituent in Isatin-3-acylhydrazones and Their Antimicrobial Activity
AbstractWater-soluble ammonium salts were prepared by the reaction of new sterically hindered isatin derivatives with analogues of Girard's reagents....
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Application of thin-layer chromatography in the assessment of bioactivity properties of isatin derivatives
In the last 20 years, isatin and its derivatives stand out as promising precursors in the synthesis of new pharmacologically active compounds. Since...
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Green synthesis of isatin-based compounds
Isatin and related derivatives are synthetically versatile substrates. These compounds can form a wide range of heterocyclic structures. These...
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Synthesis and Anti-Tumor Activity of New Isatin Derivatives
AbstractA series of new isatin derivatives was synthesized and evaluated for anti-proliferative activity against SNU-398 and LO2 cells through CCK-8...
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Biologically Active Ammonium Isatin-3-acylhydrazones Bearing Long-Chain Alkyl Substituent of Various Structures
AbstractNew ammonium hydrazones have been synthesized by the reaction of Girard’s reagents T and P with isatin derivatives that contain various alkyl...
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Review on Isatin- A Remarkable Scaffold for Designing Potential Therapeutic Complexes and Its Macrocyclic Complexes with Transition Metals
Role of synthetic coordination chemistry in pharmaceutical science is expeditiously increased due to its sundry relevances in this field. The present...
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Biologically Active Symmetric and Asymmetric Dicationic Bis(isatin hydrazones): What is Better―To Complicate or Simplify the Spacer?
AbstractThe reaction of bisisatins containing a 1,ω-alkylene, -arylene, or -alkyluracil spacer with ammonium acetohydrazides gave a series of...
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Synthesis, structure elucidation, antioxidant properties, and theoretical calculations of new Schiff bases–isatin derivatives
Isatin-derived Schiff bases are the subject of many studies, finding wide application areas in polymer technology, pharmaceutical industry, and...
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Sterically Hindered Phenolic Isatin Derivatives Containing a DABCO Fragment: Synthesis and Antimicrobial Activity Testing
AbstractThe condensation of phenolic isatin derivatives with 1-(2-hydrazinyl-2-oxoethyl)-4-aza-1-azoniabicyclo[2.2.2]octane bromide yielded a series...
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Photoreduction and Photoinitiating Ability of 1-Hexadecyl Isatin Derivatives Containing Chemically Different Substituents in the 5-Position
AbstractNew 1-hexadecyl derivatives of isatin containing substituents of various natures in the 5-position have been synthesized and characterized....
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Design and synthesis of triazole-functionalized isatin hybrids with potent anti-proliferative action against triple-negative breast cancer MDA-MB-231 cell line: a hybrid pharmacophore approach
Differently substituted novel 1-(2-((aryl-4 H -1,2,4-triazol-3-yl)thio)acetyl)indoline-2,3-diones have been synthesized, geometrically optimized, and...
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Electrochemical characterization of isatin-thiosemicarbazone derivatives
AbstractHerein, we have notably described the electrochemical behavior of four isatin-thiosemicarbazone derivatives. In this regard, cyclic...
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Substituted isatin-thiosemicarbazones containing d-galactose moiety: Synthesis, antimicrobial inhibition assay and molecular simulation study
Thiosemicarbazone scaffolds had multifaceted reactivity as well as exhibit a remarkable range of biological activity, such as anti-oxidant,...
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QSAR and molecular docking studies of isatin and indole derivatives as SARS 3CLpro inhibitors
The 3C-like protease (3CL pro ), known as the main protease of SARS-COV, plays a vital role in the viral replication cycle and is a critical target for...
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Coordination behavior, structural, statistical and theoretical investigation of biologically active metal-based isatin compounds
Isatin-core-containing ligands were synthesized by reacting an equimolar ratio of isatin with ethanolamine and anthranilic acid, respectively. The...
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Optimisation of the corrosion inhibition performance of isatin 4-ethyl-3-thiosemicarbazone for mild steel in sulfuric acid medium using response surface methodology
Sulfuric acid (H 2 SO 4 ) has been widely used in the industrial sector to eliminate rust and undesirable scales from mild steel. However, the aggressive...
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Insighting isatin derivatives as potential antiviral agents against NSP3 of COVID-19
The world is now facing intolerable damage in all sectors of life because of the deadly COVID-19 pandemic caused by the severe acute respiratory...
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Antimicrobial evaluation, in silico ADMET prediction, molecular docking, and molecular electrostatic potential of pyrazole-isatin and pyrazole-indole hybrid molecules
Exploring novel classes of antimicrobial therapeutics is an excellent approach to face the different health problems such as microbial resistance. In...
