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Efficient production of a cyclic dipeptide (cyclo-TA) using heterologous expression system of filamentous fungus Aspergillus oryzae
BackgroundCyclic dipeptides are an important class of natural products owing to their structural diversity and biological activities. In fungi, the...
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Cyclization of L-Leucyl-L-valine Dipeptide in the Crystal Phase under Non-Isоthermal Conditions
AbstractThermal treatment of linear dipeptides in solid state makes it possible to obtain their cyclic analogues in high yield and without additional...
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Cyclization of the l-alanyl-l-isoleucine dipeptide in the solid state: effect of the amino acid sequence on the reaction kinetics
The solid-state cyclization of the l -alanyl- l -isoleucine dipeptide on heating was studied. The kinetic parameters of this reaction, including the...
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Kinetics of the Solid-State Cyclization of Glycylglycine Dipeptide
AbstractThe cyclization of glycylglycine dipeptide in the solid state under heating to form 2,5-diketopiperazine was studied, and its temperature...
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Research on the Electronic Properties of Tyrosine Dipeptide Molecule: Evaluation of the First-principles Theory
AbstractTyrosine dipeptide (YY) nanotubes have recently been applied as functional elements of photoelectric sensors. Based on the first-principles,...
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Exploring bat-inspired cyclic tryptophan diketopiperazines as ABCB1 Inhibitors
Chemotherapy-induced drug resistance remains a major cause of cancer recurrence and patient mortality. ATP binding cassette subfamily B member 1...
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Active site remodelling of a cyclodipeptide synthase redefines substrate scope
Cyclodipeptide synthases (CDPSs) generate a wide range of cyclic dipeptides using aminoacylated tRNAs as substrates. Histidine-containing cyclic...
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Syntheses of Biobased Polymers Using Bio/Naturally Derived Products
Various kinds of bioplastics were synthesized using the corresponding bio-derived raw materials. Since hydroxycinnamic acids, which are abundant in...
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A Novel Enzyme-Based Electrochemical Biosensor for Sensitive Detection of Hydrogen Peroxide Based on the Fluorescent Peptide Self-Assembled Nanomaterials
Advancing enzyme-based electrochemical biosensor research heightens the need for improved biosafety and reduced biotoxicity. Conventional electrode...
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Photochemistry of phthalimidoadamantane dipeptides: effect of amino acid side chain on photocyclization
A series of dipeptides 1 was synthesized that at the N-site contained 3-( N -phthalimidoadamantane-1-carboxylic acid and at the C-site different...
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Synthesis of Phosphinic Pseudomethionyl-Glutamyl-Histidine
AbstractThe amidoalkylation of a phosphonous acid containing a structural isostere of diethyl glutamiate, using ethyl carbamate and...
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Promoted Comprehensive Properties of Polyisoprene Rubber with Extremely High Fatigue Resistance Enabled by Oligopeptide Aggregates
For decades, the preparation of polyisoprene rubber that can match the comprehensive properties of natural rubber (NR) has been pursued. While...
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Mechanistic insight into the tautomerization of histidine initiated by water-catalyzed N–H and C–H cleavages
The N–H and C–H activation is of great significance in organic chemistry and chemical industry fields, especially, in the utilization of petroleum...
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Cyclic Depsipeptides, Callipeltins
Marine sponges are considered as an untapped reservoir of biologically active natural compounds exhibiting numerous interesting and potentially...
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In vitro and in silico characterization of adiponectin-receptor agonist dipeptides
The aim of this study is to develop a dipeptide showing an adiponectin receptor 1 (AdipoR1) agonistic effect in skeletal muscle L6 myotubes. Based on...
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Molecular self-assembled helix peptide nanotubes based on some amino acid molecules and their dipeptides: molecular modeling studies
ContextThe paper considers the features of the structure and dipole moments of several amino acids and their dipeptides which play an important role...
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Peptide Macrocyclization Through Palladium-Catalyzed Late-Stage C-H Activation
Cyclic peptides are an important class of bioactive compounds for the chemical biology and pharmaceutical industry. Chemical synthesis of highly...
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Improved prediction and characterization of blood-brain barrier penetrating peptides using estimated propensity scores of dipeptides
The blood-brain barrier (BBB) is the primary barrier with a highly selective semipermeable border between blood vascular endothelial cells and the...
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Quantification of Proline-containing Cyclic Dipeptides by LC-MS/MS
The cyclic dipeptides, 2,5-diketopiperazines (DKPs), draw attention as bioactive and taste compounds. DKPs, especially those containing Proline...
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Repurposing a plant peptide cyclase for targeted lysine acylation
Transpeptidases are powerful tools for protein engineering but are largely restricted to acting at protein backbone termini. Alternative enzymatic...
