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Highly Porous 3D Printed Scaffold Incorporated with Graphene Oxide-Merwinite and Coated with IGF1 Loaded Nanofibers for Calvarial Defect Repair
Critical-sized calvarial bone defects remain a significant challenge in orthopedic surgery, especially for irregularly shaped bones. Herein, we...
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Investigation into the effects of leukemia inhibitory factor on the bone repair capacity of BMSCs-loaded BCP scaffolds in the mouse calvarial bone defect model
Leukemia inhibitory factor (LIF) is known to play a major role in bone physiology. In the present study, we examined the in vitro effects of LIF on...
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Injectable ultrasound-powered bone-adhesive nanocomposite hydrogel for electrically accelerated irregular bone defect healing
The treatment of critical-size bone defects with irregular shapes remains a major challenge in the field of orthopedics. Bone implants with...
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Nanosilicate-functionalized nanofibrous membrane facilitated periodontal regeneration potential by harnessing periodontal ligament cell-mediated osteogenesis and immunomodulation
Although various new biomaterials have enriched the methods for periodontal regeneration, their efficacy is still controversial, and the regeneration...
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Catechol- and thiol-containing binder that aggregates granular xenografts in reconstructed bone defects by mimicking mussel wet adhesion
Xenograft bone granules are bone graft materials that are widely used to reconstruct bone tissue in clinical practice, and their clinical success...
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Nacre-mimetic cerium-doped nano-hydroxyapatite/chitosan layered composite scaffolds regulate bone regeneration via OPG/RANKL signaling pathway
Autogenous bone grafting has long been considered the gold standard for treating critical bone defects. However, its use is plagued by numerous...
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Hydrogel armed with Bmp2 mRNA-enriched exosomes enhances bone regeneration
BackgroundSustained release of bioactive BMP2 (bone morphogenetic protein-2) is important for bone regeneration, while the intrinsic short half-life...
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BMSC exosome-enriched acellular fish scale scaffolds promote bone regeneration
Tissue engineering scaffolds are essential for repairing bone defects. The use of biomimetic scaffolds for bone tissue engineering has been...
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Exosomal Lnc NEAT1 from endothelial cells promote bone regeneration by regulating macrophage polarization via DDX3X/NLRP3 axis
BackgroundBone regeneration is a complex procedure that involves an interaction between osteogenesis and inflammation. Macrophages in the...
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Improvement of Bone Formation in Rats with Calvarial Defects by Modulating the Pore Size of Tricalcium Phosphate Scaffolds
The use of multi-porous scaffolds for bone tissue engineering has been shown to improve osteogenesis. Although the exact mechanisms by which these...
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The Influence of Extracellular Vesicles Secreted by Dural Cells on Osteoblasts
To explore the influence of extracellular vesicles secreted by dural cells (Dura-EVs) on osteoblasts. Our methodology involves assessing the effects...
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Hydrogel Biomaterial in Bone Tissue Engineering
The repair of critical-sized bone defect caused by trauma or disease poses a remarkable clinical challenge. Even though conventional methods such as...
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Yoda1 pretreated BMSC derived exosomes accelerate osteogenesis by activating phospho-ErK signaling via Yoda1-mediated signal transmission
Segmental bone defects, arising from factors such as trauma, tumor resection, and congenital malformations, present significant clinical challenges...
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Sustained zinc release in cooperation with CaP scaffold promoted bone regeneration via directing stem cell fate and triggering a pro-healing immune stimuli
Metal ions have been identified as important bone metabolism regulators and widely used in the field of bone tissue engineering, however their exact...
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A xonotlite nanofiber bioactive 3D-printed hydrogel scaffold based on osteo-/angiogenesis and osteoimmune microenvironment remodeling accelerates vascularized bone regeneration
BackgroundCoordination between osteo-/angiogenesis and the osteoimmune microenvironment is essential for effective bone repair with biomaterials. As...
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Engineering a triple-functional magnetic gel driving mutually-synergistic mild hyperthermia-starvation therapy for osteosarcoma treatment and augmented bone regeneration
Malignant bone tumors result in high rates of disability and death and are difficult to treat in terms of killing tumors and repairing bone defects....
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Interaction of alginate with nano-hydroxyapatite-collagen using strontium provides suitable osteogenic platform
BackgroundHydrogels based on organic/inorganic composites have been at the center of attention for the fabrication of engineered bone constructs. The...
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PLGA nanoparticles engineering extracellular vesicles from human umbilical cord mesenchymal stem cells ameliorates polyethylene particles induced periprosthetic osteolysis
The wear particle-induced dissolution of bone around implants is a significant pathological factor in aseptic loosening, and controlling prosthetic...
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Bone mesenchymal stem cells stimulation by magnetic nanoparticles and a static magnetic field: release of exosomal miR-1260a improves osteogenesis and angiogenesis
BackgroundThe therapeutic potential of exosomes derived from stem cells has attracted increasing interest recently, because they can exert similar...
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Self-healing hybrid hydrogels with sustained bioactive components release for guided bone regeneration
Guided bone regeneration (GBR) is widely used in treating oral bone defects to exclude the influence of non-osteogenic tissue on the bone healing...
