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Chemistry

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Showing 1-9 of 9 results

  1. The m6A Reader YTHDC2 Suppresses Lung Adenocarcinoma Tumorigenesis by Destabilizing MRPL12

    N6-methyladenosine (m6A) is the most common posttranscriptional RNA modification and plays significant roles in physiological and pathological...

    Yingchuan Sun, Yanyan Liu, ... Jianmin Huang in Molecular Biotechnology
    Article 21 December 2023

  2. YTHDC2 Retards Cell Proliferation and Triggers Apoptosis in Papillary Thyroid Cancer by Regulating CYLD-Mediated Inactivation of Akt Signaling

    N6-Methyladenosine (m 6 A) mRNA methylation modification is regarded as an important mechanism involved in diverse physiological processes. YT521-B...

    Guangying Zhou, Shasha Wang in Applied Biochemistry and Biotechnology
    Article 10 May 2023

  3. m6A mRNA methylation initiated by METTL3 inhibits KDR translation to increase the efficacy of 131I therapy in papillary thyroid carcinoma

    Papillary thyroid carcinoma (PTC) is a common malignant tumor. 131 I treatment can effectively kill residual PTC microtissues and inhibit metastases....

    Wei Nie in Journal of Radioanalytical and Nuclear Chemistry
    Article 25 May 2023

  4. Crosstalk Between m6A RNA Methylation and miRNA Biogenesis in Cancer: An Unholy Nexus

    N6-methyladenosine (m6A) is one of the most prevalent internal reversible chemical modification of RNAs in eukaryotes, which has attracted widespread...

    P. J. Jayasree, Shalmoli Dutta, ... Piyush Khandelia in Molecular Biotechnology
    Article 13 October 2023

  5. YTHDC1-Mediated lncRNA MSC-AS1 m6A Modification Potentiates Laryngeal Squamous Cell Carcinoma Development via Repressing ATXN7 Transcription

    Laryngeal squamous cell carcinoma (LSCC) has the highest mortality rate among head and neck squamous cell carcinoma. This study was designed to...

    Shu Zhang, Qun Wu, ... Bo Kou in Molecular Biotechnology
    Article 18 April 2024

  6. m6A RNA Methylation: Ramifications for Gene Expression and Human Health

    Cellular transcriptomes are frequently adorned by a variety of chemical modification marks, which in turn have a profound influence on its...

    R. Karthiya, Piyush Khandelia in Molecular Biotechnology
    Article 25 August 2020

  7. Understanding m6A Function Through Uncovering the Diversity Roles of YTH Domain-Containing Proteins

    N 6 -methyladenosine (m 6 A) is the most abundant—internal modification of eukaryotic mRNA. m 6 A can be installed and removed by specific enzymes. The...

    Y. L. Zhao, Y. H. Liu, ... X. X. Wang in Molecular Biotechnology
    Article 12 January 2019

  8. N 6-Methyladenosine (m6A) Methylation in mRNA with A Dynamic and Reversible Epigenetic Modification

    N 6 -methyladenosine (m 6 A) is the most abundant and reversible internal modification ubiquitously occurring in eukaryotic mRNA, albeit the significant...

    Ruifan Wu, Denghu Jiang, ... **nxia Wang in Molecular Biotechnology
    Article 14 May 2016

  9. Structural basis for selective binding of m6A RNA by the YTHDC1 YTH domain

    N 6 -methyladenosine (m 6 A) is the most abundant internal modification of nearly all eukaryotic mRNAs and has recently been reported to be recognized by...

    Chao Xu, **ao Wang, ... **rong Min in Nature Chemical Biology
    Article 21 September 2014
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