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Ferrocene–Peptide Bioconjugates
This chapter sketches an outline of ferrocene–peptide bioconjugates. A variety of ferrocene–peptide bioconjugates have been designed to induce...
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One-Step Homogeneous Immunoassay for the Detection of Influenza Virus Using Switching Peptide and Graphene Quencher
One-step homogeneous immunoassay was developed for detecting influenza viruses A and B (Inf-A and Inf-B) using the switching peptide H2. As the...
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One-step immunoassay based on switching peptides for analyzing ochratoxin A in wines
A one-step immunoassay is presented for the detection of ochratoxin A (OTA) using an antibody complex with switching peptides. Because the switching...
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Breaking barriers in electrochemical biosensing using bioinspired peptide and phage probes
Electrochemical biosensing continues to advance tirelessly, overcoming barriers that have kept it from leaving research laboratories for many years....
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Sulfonium-Tethered Peptide
Stapled peptides have received widespread attention in therapeutics due to the superior membrane penetration and in vivo stability. We have developed...
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Construction of functional microtubules and artificial motile systems based on peptide design
Peptides are versatile molecular tools that can self-assemble and participate in molecular recognition processes. Our group has developed rationally...
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Protocols for Building and Producing High Diversity Peptide Phage Display Libraries
Phage display is an important technology to study protein-protein interaction and protein evolution, with applications in basic science and applied...
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MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange
Presentation of antigenic peptides by major histocompatibility complex class II (MHC-II) proteins determines T helper cell reactivity. The MHC-II...
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Rationally Designed DNA-Based Scaffolds and Switching Probes for Protein Sensing
The detection of a protein analyte and use of this type of information for disease diagnosis and physiological monitoring requires methods with high...
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Advancement and application of novel cell-penetrating peptide in cancer management
Cell-penetrating peptides (CPPs) are small amino acid sequences with the potential to enter cell membranes. Along with nucleic acids, large proteins,...
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Subdomain dynamics enable chemical chain reactions in non-ribosomal peptide synthetases
Many peptide-derived natural products are produced by non-ribosomal peptide synthetases (NRPSs) in an assembly-line fashion. Each amino acid is...
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Exploring binding positions and backbone conformations of peptide ligands of proteins with a backbone-centred statistical energy function
When designing peptide ligands based on the structure of a protein receptor, it can be very useful to narrow down the possible binding positions and...
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A high-throughput sequence determination for one cyclic peptide immobilized on a single bead by the one-pot cyanidation followed by MALDI-TOF–MS/MS for discovery of interacting peptides
One cyclic peptide immobilized on one gel-type bead has been employed for the discovery of both interacting peptides and/or medicinal medium-sized...
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Development and Characterization of Light-Responsive Peptide Macrocycles
Small molecules, peptide macrocycles, and protein conjugates that reversibly turn their function on and off in response to visible light enabled the...
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Controlling oncogenic KRAS signaling pathways with a Palladium-responsive peptide
RAS oncoproteins are molecular switches associated with critical signaling pathways that regulate cell proliferation and differentiation. Mutations...
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Metal Peptide Conjugates in Cell and Tissue Imaging and Biosensing
Metal complex luminophores have seen dramatic expansion in application as imaging probes over the past decade. This has been enabled by growing...
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A Significant Difference in Core PDZ Interactivity of SARS-CoV, SARS-CoV2 and MERS-CoV Protein E Peptide PDZ Motifs In Vitro
Small structural E protein of coronaviruses uses its C-terminal PDZ motif to compromise the cellular PDZ interactome. In this work we compared core...
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Directing ricin-based immunotoxins with targeting affibodies and KDEL signal peptide to cancer cells effectively induces apoptosis and tumor suppression
The plant toxin ricin, especially its cytotoxic A chain (RTA), can be genetically engineered with targeting ligands to develop specific anti-cancer...
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External Stimulation-Responsive Artificial Nucleic Acids: Peptide Ribonucleic Acid (PRNA)-Programmed Assemblies
Stimulus-response control of functions, induced by conformational and/or structural changes of nucleic acids and their derivatives, has attracted...
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Using a peptide-based mass spectrometry approach to quantitate proteolysis of an intact heterogeneous procollagen substrate by BMP1 for antagonistic antibody screening
Proteases are critical proteins involved in cleaving substrates that may impact biological pathways, cellular processes, or disease progression. In...
