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Monitoring Multidrug Resistance P-Glycoprotein Drug Transport Activity with Single-Photon Emission Computed Tomography and Positron Emission Tomography Radiopharmaceuticals
Multidrug resistance (MDR) mediated by overexpression of MDR1 P-glycoprotein (Pgp) is one of the best characterized transporter-mediated barriers to... -
Surface ligand-regulated renal clearance of MRI/SPECT dual-modality nanoprobes for tumor imaging
BackgroundThe general sluggish clearance kinetics of functional inorganic nanoparticles tend to raise potential biosafety concerns for in vivo...
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Computed Tomography
Computed tomography (CT) is widely used to visualize the cross-section of a sample with non-destructive techniques in clinical and industrial... -
A novel superparamagnetic iron oxide nanoparticles-based SPECT/MRI dual-modality probe for tumor imaging
Multimodal imaging has become a trend in the development of molecular imaging. For SPECT/MRI dual-modality imaging, we developed a SPECT/MRI...
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Technetium-99m and ICG-labeled HPG (hyperbranched polyglycerol) as a SPECT/FL dual imaging nanoprobe for imaging blood cells: in vitro investigation using myelogenous leukemia cells
This study aimed to develop a single photo emission computed tomography/fluorescence (SPECT/FL) bimodal imaging probe to image blood cells....
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Molecular imaging: design mechanism and bioapplications
Molecular imaging is a non-invasive method to image and analyze the concentration and activity of functional biomolecules in cells or in vivo at...
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A novel SPECT/MRI bimodal imaging probe: 99mTc-DPAPA-Fe3O4 nanoconjugate
This study aimed to create a novel bimodal probe. For this purpose, cubic iron oxide nanoparticles (C-Fe 3 O 4 NPs) conjugated with an EDTMP derivative...
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Hydrophobic insertion-based engineering of tumor cell-derived exosomes for SPECT/NIRF imaging of colon cancer
BackgroundTumor cell-derived exosomes (TEx) have emerged as promising nanocarriers for drug delivery. Noninvasive multimodality imaging for tracing...
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A Modified PEG-Fe3O4 Magnetic Nanoparticles Conjugated with D( +)Glucosamine (DG): MRI Contrast Agent
Molecular imaging (MI) can provide not only structural images utilizing temporal imaging techniques, but also functional and molecular data using a...
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Nectin-4-targeted immunoSPECT/CT imaging and photothermal therapy of triple-negative breast cancer
BackgroundTriple-negative breast cancer (TNBC) is more prone to distant metastasis and visceral recurrence in comparison to other breast cancer...
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In vivo fluorescence imaging: success in preclinical imaging paves the way for clinical applications
Advances in diagnostic imaging have provided unprecedented opportunities to detect diseases at early stages and with high reliability. Diagnostic...
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Nanoparticle-based theranostics in nuclear medicine
Nuclear medicine has revolutionized medical diagnostic and therapeutic interventions by employing radiopharmaceuticals for detection and treatment....
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NIR-II Fluorophores: From Synthesis to Biological Applications
Fluorescence imaging is a useful tool in the field of biomedical applications. However, its imaging capacity is limited by the depth of tissue that...
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Biological evaluation of [99mTc]Tc-labeled Buthus martensii Karsch Chlorotoxin peptide for glioma imaging
This study was to investigate the synthesis and biological evaluation of [ 99m Tc]Tc-labeled Buthus martensii Karsch Chlorotoxin ([ 99m Tc]Tc-BmK CT) as...
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Comparative cytotoxicity of 177Lu on various lung cancer cells and in vivo targeting of 177Lu-labeled cetuximab
Differences in cellular radiosensitivity and the binding affinity of radiopharmaceuticals could directly affect the radiotherapeutic effects. In this...
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Metal Phosphate and Phosphonate Application for Imaging and Diagnosis
Metal phosphate and phosphonate are hybrid materials prepared from the chemical interaction between organic and inorganic material that owns the... -
Silk fibroin-based embolic agent for transhepatic artery embolization with multiple therapeutic potentials
BackgroundThe excellent physicochemical and biomedical properties make silk fibroin (SF) suitable for the development of biomedical materials. In...
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Multimodal radiolabeled gold nanoparticle molecular probes: synthesis, imaging, and applications
Recent years have witnessed increasing advances in gold nanoparticles (GNPs) for accurate and precise diagnosis and therapy. GNPs have great...
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Image-guided cancer surgery: a narrative review on imaging modalities and emerging nanotechnology strategies
Surgical resection is the cornerstone of solid tumour treatment. Current techniques for evaluating margin statuses, such as frozen section, imprint...
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Water-Soluble Small Organic Fluorophores for Oncological Theragnostic Applications: Progress and Development
Cancer is one of the major noncommunicable diseases, responsible for millions of deaths every year worldwide. Though various cancer detection and...