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Computational design and engineering of self-assembling multivalent microproteins with therapeutic potential against SARS-CoV-2
Multivalent drugs targeting homo-oligomeric viral surface proteins, such as the SARS-CoV-2 trimeric spike (S) protein, have the potential to elicit...
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Vanadium complexes: potential candidates for therapeutic applications
Transition metal with variable oxidation states has always been a point of attraction since many decades for scientists with special focus in the...
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Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2
Neutralizing agents against SARS-CoV-2 are urgently needed for the treatment and prophylaxis of COVID-19. Here, we present a strategy to rapidly...
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Neem Oil (Azadirachta indica A. juss) as a Potential Natural Active Compound in Cosmetic Properties Title
Azadirachta indica A. juss (a member of the Meliaceae family) is a native tree in Myanmar that thrives in subtropical, semi-arid, and arid regions....
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Targeted Computational Approaches to Identify Potential Inhibitors for Nipah Virus
Nipah virus (NiV) is a bat-borne, highly pathogenic RNA virus belonging to the family Paramyxoviridae. It is known for causing lethal encephalitis in...
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Red blood cells: a potential delivery system
Red blood cells (RBCs) are the most abundant cells in the body, possessing unique biological and physical properties. RBCs have demonstrated...
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Assessing and optimizing the bioactivities of diverse enzyme-derived protein hydrolysates from Porphyra yezoensis: unlocking the health potential
The interest in algae-derived bioactive compounds has grown due to their potential therapeutic efficacy against a range of diseases. These compounds,...
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Bio-hydrogen-producing Potential Evaluation and Capacity Enhancement from Tobacco Processing Leftovers by Photo-fermentation Under Diverse Initial pH
The use of tobacco growing and processing residues for bio-hydrogen production is an effective exploration to broaden the source of bio-hydrogen...
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Therapeutic Potential of CPPs
Here, the brief summary of therapeuticTherapeutic developments and current situation with applications of CPPs is presented, hopefully leading to...
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In silico elucidation for the identification of potential phytochemical against ACE-II inhibitors
ContextThe present study aims to investigate the therapeutic potential of phytocompounds derived from Annona reticulata leaves for the treatment of...
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Amaranth (Amaranthus spp.): Food Properties and Potential Health Benefits
Amaranth is worldwide grown as a principal grain crop with almost 400 varieties and 70 species. It contains notable amount of primary metabolites...
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The potential of algae as a source of cellulose and its derivatives for biomedical applications
Cellulose has been intensively investigated for biomedical applications, because of its excellent properties, like biodegradability,...
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Tailoring of Gelatin-Chitosan Nanofibers Functionalized with Eucalyptus Essential Oil via Electroblowing for Potential Food Packaging and Wound Dressing Applications
In recent years, new approaches to fabricating nanofiber networks for potential applications in wound dressing and food packaging have been in the...
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Lumacaftor as a potential repurposed drug in targeting breast cancer stem cells: insights from in silico study
ContextBreast cancer stem cells (BCSCs) are a small subset of cells within breast tumors with characteristics similar to normal stem cells. Despite...
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Adenosine A2A Receptor Antagonists: Chemistry, SARs, and Therapeutic Potential
Many physiological processes are modulated by the naturally occurred nucleoside adenosine after interaction with four G-protein-coupled receptor...
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Hit discovery of potential CDK8 inhibitors and analysis of amino acid mutations for cancer therapy through computer-aided drug discovery
Cyclin-dependent kinase 8 (CDK8) has emerged as a promising target for inhibiting cancer cell function, intensifying efforts towards the development...
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In silico identification of novel stilbenes analogs for potential multi-targeted drugs against Alzheimer’s disease
ContextAlzheimer’s disease (AD) is a chronic progressive neurodegenerative syndrome, which adversely disturbs cognitive abilities as well as...
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Assessment of bacteriocin production by clinical Pseudomonas aeruginosa isolates and their potential as therapeutic agents
IntroductionBacterial infections and the rising antimicrobial resistance pose a significant threat to public health. Pseudomonas aeruginosa produces...
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Environmentally friendly catalyst- and solvent-free synthesis of 2-anilino nicotinic acids derivatives as potential lead COX inhibitors
In this study, an environmentally friendly, solvent- and catalyst-free synthesis of 2-anilino nicotinic acids derivatives is reported. This...
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Counter-ion adsorption and electrostatic potential in sodium and choline dodecyl sulfate micelles — a molecular dynamics simulation study
ContextCholine-based surfactants are interesting both from the practical point of view to obtaining environmental-friendly surfactants as well as...
