Search
Search Results
-
Identification of RimR2 as a positive pathway-specific regulator of rimocidin biosynthesis in Streptomyces rimosus M527
BackgroundStreoptomyces rimosus M527 is a producer of the polyene macrolide rimocidin which shows activity against various plant pathogenic fungi....
-
Engineering Streptomyces sp. CPCC 204095 for the targeted high-level production of isatropolone A by elucidating its pathway-specific regulatory mechanism
BackgroundIsatropolone A and C, produced by Streptomyces sp. CPCC 204095, belong to an unusual class of non-benzenoid aromatic compounds and contain...
-
Enhanced production of terrein in marine-derived Aspergillus terreus by refactoring both global and pathway-specific transcription factors
BackgroundTerrein, a major secondary metabolite from Aspergillus terreus , shows great potentials in biomedical and agricultural applications....
-
Characterization of a pleiotropic regulator MtrA in Streptomyces avermitilis controlling avermectin production and morphological differentiation
BackgroundThe macrolide antibiotic avermectin, a natural product derived from Streptomyces avermitilis , finds extensive applications in agriculture,...
-
Deciphering the pathway-specific regulatory network for production of ten-membered enediyne Tiancimycins in Streptomyces sp. CB03234-S
BackgroundThe anthraquinone-fused 10-membered enediynes (AFEs), represented by tiancimycins (TNMs), possess a unique structural feature and promising...
-
PlgMYBR1, an R2R3-MYB transcription factor, plays as a negative regulator of anthocyanin biosynthesis in Platycodon grandiflorus
Floral color plays a major role in pollinator specificity, and changes in color may result in pollinator shifts and pollinator-mediated speciation....
-
PAS domain containing regulator SLCG_7083 involved in morphological development and glucose utilization in Streptomyces lincolnensis
BackgroundStreptomyces lincolnensis is well known for producing the clinically important antimicrobial agent lincomycin. The synthetic and...
-
Micronome Revealed miR-205-5p as Key Regulator of VEGFA During Cancer Related Angiogenesis in Hepatocellular Carcinoma
The high ratio of global mortality rate to incidence rate and steep increase in incidence of liver cancer warrants need for advancement of innovative...
-
MicroRNA-425: A Pivotal Regulator Participating in Tumorigenesis of Human Cancers
MicroRNAs (miRNAs) are small single-stranded regulatory RNAs that are shown to be dysregulated in a wide array of human cancers. MiRNAs play critical...
-
Results
The aim of the work was to activate antibiotic biosynthetic gene cluster expression of prioritized genome-sequenced actinomycetes with the help of...
-
SARP-Driven Activation of Antibiotic Biosynthetic Gene Clusters in Actinomycetes
Actinomycetes are a group of Gram-positive bacteria of which many representatives are prominent for being prolific producers of bioactive natural...
-
A TetR family transcriptional regulator, SP_2854 can affect the butenyl-spinosyn biosynthesis by regulating glucose metabolism in Saccharopolyspora pogona
BackgroundButenyl-spinosyn produced by Saccharopolyspora pogona exhibits strong insecticidal activity and a broad pesticidal spectrum. Currently,...
-
Determination of the regulatory network and function of the lysR-type transcriptional regulator of Lactiplantibacillus plantarum, LpLttR
BackgroundLactiplantibacillus plantarum has various healthcare functions including the regulation of immunity and inflammation, reduction of serum...
-
GATA25, a novel regulator, accelerates the flowering time of Arabidopsis thaliana
Intrinsic and exogenous signals in conjunction precisely regulate the initiation of flowering. Both signals influence flowering time, which is an...
-
AdpA, a developmental regulator, promotes ε-poly-l-lysine biosynthesis in Streptomyces albulus
BackgroundAdpA is a global regulator of morphological differentiation and secondary metabolism in Streptomyces, but the regulatory roles of the Streptomyces...
-
Structural basis for persulfide-sensing specificity in a transcriptional regulator
Cysteine thiol-based transcriptional regulators orchestrate the coordinated regulation of redox homeostasis and other cellular processes by ‘sensing’...
-
Chemical genomics with pyrvinium identifies C1orf115 as a regulator of drug efflux
Pyrvinium is a quinoline-derived cyanine dye and an approved anti-helminthic drug reported to inhibit WNT signaling and have anti-proliferative...
-
Production of Cadaverine in Recombinant Corynebacterium glutamicum Overexpressing Lysine Decarboxylase (ldcC) and Response Regulator dr1558
In this study, the response regulator DR1558 from Deinococcus radiodurans was overexpressed in recombinant Corynebacterium glutamicum with lysine...
-
Increasing Demeclocycline Production in Streptomyces aureofaciens by Manipulating the Expression of a Novel SARP Family Regulator and Its Genes
Demeclocycline (DMCTC), a tetracycline derivative antibiotic produced by Streptomyces aureofaciens , has attracted attention owing to its high...
-
Rational construction of a high-quality and high-efficiency biosynthetic system and fermentation optimization for A82846B based on combinatorial strategies in Amycolatopsis orientalis
BackgroundOritavancin is a new generation of semi-synthetic glycopeptide antibiotics against Gram-positive bacteria, which served as the first and...
