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An update on pathogenesis and clinical scenario for Parkinson’s disease: diagnosis and treatment
In severe cases, Parkinson’s disease causes uncontrolled movements known as motor symptoms such as dystonia, rigidity, bradykinesia, and tremors....
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The Interplay Between Epilepsy and Parkinson’s Disease: Gene Expression Profiling and Functional Analysis
The results of many epidemiological studies suggest a bidirectional causality may exist between epilepsy and Parkinson’s disease (PD). However, the...
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Pharmacophore modelling and molecular dynamics simulation to identify novel molecules targeting catechol-O-methyltransferase and dopamine D3 receptor to combat Parkinson’s disease
Parkinson’s disease is a neurological illness that slowly impairs a small number of neurons in the substantia nigra, a part of the brain. Dopamine, a...
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Repositioning of drugs for Parkinson’s disease and pharmaceutical nanotechnology tools for their optimization
Parkinson’s disease (PD) significantly affects patients’ quality of life and represents a high economic burden for health systems. Given the lack of...
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Deciphering the neuroprotective effect of ascorbic acid mediated synthesis of iron oxide nanoparticles against Parkinson’s disease: an in vitro and in vivo approach
One of the most prevalent neurological movement diseases affecting the geriatric population globally is Parkinson’s disease (PD). Recent studies have...
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Electromagnetic field-enhanced chiral dimanganese trioxide nanoparticles mitigate Parkinson’s disease
The misfolding and aggregation of α-synuclein (α-syn) is closely associated with Parkinson’s disease (PD). Here, chiral dimanganese trioxide (Mn 2 O 3 )...
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Lab-made disposable screen-printed electrochemical sensors and immunosensors modified with Pd nanoparticles for Parkinson’s disease diagnostics
A new conductive ink based on the addition of carbon black to a poly(vinyl alcohol) matrix is developed and investigated for electrochemical sensing...
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An amino-rich polymer-coated magnetic nanomaterial for ultra-rapid separation of phosphorylated peptides in the serum of Parkinson’s disease patients
The elucidation of disease pathogenesis can be achieved by analyzing the low-abundance phosphopeptides in organisms. Herein, we developed a novel and...
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Quantum Chemical Investigation, Drug-Likeness and Molecular Docking Studies on Galangin as Alpha-Synuclein Regulator for the Treatment of Parkinson’s Disease
Globally the leading source of disability is neurological disorder. The chronic, complex and rapidly progressive neurological disorder in the world...
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The impact of ATP-sensitive potassium channel modulation on mitochondria in a Parkinson’s disease model using SH-SY5Y cells depends on their differentiation state
Inward rectifying potassium channels sensitive to ATP levels (KATP) have been the subject of investigation for several decades. Modulators of KATP...
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Evidence of brain target engagement in Parkinson’s disease and multiple sclerosis by the investigational nanomedicine, CNM-Au8, in the REPAIR phase 2 clinical trials
BackgroundImpaired brain energy metabolism has been observed in many neurodegenerative diseases, including Parkinson’s disease (PD) and multiple...
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Plant-Derived Natural Products Targeting Multiple Pathways as Potential Therapeutics in the Treatment of Parkinson’s Disease
Parkinson’s disease (PD) is a chronic neurodegenerative disorder (ND) characterised by gradual degradation of dopaminergic neurons in the substantia...
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Hsa_circ_0054220 Upregulates HMGA1 by the Competitive RNA Pattern to Promote Neural Impairment in MPTP Model of Parkinson’s Disease
Parkinson’s disease (PD) is a common neurodegenerative disease. Circular RNAs (circRNAs) have been confirmed to regulate neurodegenerative diseases....
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Study of the Effects of Nicotine and Caffeine for the Treatment of Parkinson’s Disease
Parkinson’s disease (PD) is considered to be a highly severe neurological disorder. PD occurs due to a decrease in dopamine production by the...
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A review of the current research on in vivo and in vitro detection for alpha-synuclein: a biomarker of Parkinson’s disease
Parkinson’s disease is a health-threatening neurodegenerative disease of the elderly with clinical manifestations of motor and non-motor deficits...
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Microfluidics-enabled mesenchymal stem cell derived Neuron like cell membrane coated nanoparticles inhibit inflammation and apoptosis for Parkinson’s Disease
Parkinson’s disease (PD) is the second largest group of neurodegenerative diseases, and its existing drug treatments are not satisfactory. Natural...
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Matrisome changes in Parkinson’s disease
Extracellular matrix (ECM) proteins, collectively known as the matrisome, include collagens, glycoproteins, and proteoglycans. Alterations in the...
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Identification of Bile Acid-Derived Chemical Chaperone(s) Targeting E46K-Mutated Alpha-Synuclein Protein to Treat Parkinson’s Disease: Molecular Modelling, Docking, ADME, and Simulation Studies
Aggregated α-synuclein (α-syn) present inside small cytoplasmic inclusions in the substantia nigra region marks the major pathological hallmark of...
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Mitochondria–lysosome crosstalk in GBA1-associated Parkinson’s disease
Organelle crosstalk is significant in regulating their respective functions and subsequent cell fate. Mitochondria and lysosomes are amongst the...
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Novel therapeutic targets to halt the progression of Parkinson’s disease: an in-depth review on molecular signalling cascades
Recent research has focused mostly on understanding and combating the neurodegenerative mechanisms and symptoms of Parkinson’s disease (PD)....
