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Chemical insertion of anthracene moiety into the backbone of a newly synthesized oligophenylene (OMPA): effect on the photo-physical properties
The newly synthesized oligo[4-(methoxyphenyl) acetonitrile] (OMPA) was chemically modified by Knoevenagel condensation of OMPA oligomer with...
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Human super antibody to viral RNA-dependent RNA polymerase produced by a modified Sortase self-cleave-bacteria surface display system
BackgroundRNA-dependent RNA polymerase (RdRp) is a good target of anti-RNA virus agents; not only it is pivotal for the RNA virus replication cycle...
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Protein–lipid charge interactions control the folding of outer membrane proteins into asymmetric membranes
Biological membranes consist of two leaflets of phospholipid molecules that form a bilayer, each leaflet comprising a distinct lipid composition....
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Enhancing immune responses of ESC-based TAA cancer vaccines with a novel OMV delivery system
Embryonic stem cell (ESC)-derived epitopes can act as therapeutic tumor vaccines against different types of tumors ** (Adv Healthc Mater 2023)....
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The Molecular Dynamics Simulation of a Multi-domain Outer Membrane Protein A (OmpA) from Shigella flexneri in POPE Lipid Bilayer
Shigella flexneri serotype 2a is a major public health concern in the develo** and under-developed countries as it contributes to the endemic...
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Functional Display of an Amoebic Chitinase in Escherichia coli Expressing the Catalytic Domain of EhCHT1 on the Bacterial Cell Surface
Poor solubility is the main drawback of the direct industrial exploitation of chitin, the second most abundant biopolymer after cellulose. Chemical...
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Quantitative measurement of cell-surface displayed proteins based on split-GFP assembly
BackgroundMicrobial cell surface display technology allows immobilizing proteins on the cell surface by fusing them to anchoring motifs, thereby...
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The involvement of the Type Six Secretion System (T6SS) in the virulence of Ralstonia solanacearum on brinjal
Ralstonia solanacearum is an important soil-borne plant pathogen which causes bacterial wilt in a large number of crops. Bacterial Type Six Secretion...
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Expression of stress regulator and virulence genes of Cronobacter sakazakii strain Yrt2a as a response to acid stress
This research aimed to evaluate the effect of acid stress on the expression of stress regulator ( grxB and rpoS ) and virulence ( ompA, hfq, and cpa )...
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Escherichia coli displays a conserved membrane proteomic response to a range of alcohols
BackgroundAlcohol is a good and environment-friendly fuel that can be microbially produced, capable of eliminating many of the limitations of the...
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Systematic engineering pinpoints a versatile strategy for the expression of functional cytochrome P450 enzymes in Escherichia coli cell factories
Production of plant secondary metabolites in engineered microorganisms provides a scalable and sustainable alternative to their sourcing from nature...
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Light regulation in critical human pathogens of clinical relevance such as Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa
It is now clearly recognized that light modulates the physiology of many bacterial chemotrophs, either directly or indirectly. An interesting case...
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Detoxified synthetic bacterial membrane vesicles as a vaccine platform against bacteria and SARS-CoV-2
The development of vaccines based on outer membrane vesicles (OMV) that naturally bud off from bacteria is an evolving field in infectious diseases....
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Role of Biosurfactants in Enzyme Production
A biosurfactant is described as a “biosurface active” compound synthesized by various microbes. The purified microbial form of biosurfactant is...
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Ultrahigh-throughput screening-assisted in vivo directed evolution for enzyme engineering
BackgroundClassical directed evolution is a powerful approach for engineering biomolecules with improved or novel functions. However, it...
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Discovery of Antimicrobial Peptide Macrocycles Through Bacterial Display
Peptide macrocycles exhibit great ability to inhibit bacterial growth making them a promising new avenue for antimicrobial discovery. Surface...
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N-Terminal Fused Signal Peptide Prompted Extracellular Production of a Bacillus-Derived Alkaline and Thermo Stable Xylanase in E. coli Through Cell Autolysis
Xylanases are extensively used as industrial enzymes for its ability of hydrolyzing xylan to oligosaccharides. Here, XynHB, a thermo and alkaline...
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Construction of Cupriavidus necator displayed with superoxide dismutases for enhanced growth in bioelectrochemical systems
It is of great significance to utilize CO 2 as feedstock to synthesize biobased products, particularly single cell protein (SCP) as the alternative...
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Identification of Antigenic Properties of Acinetobacter baumannii Proteins as Novel Putative Vaccine Candidates Using Reverse Vaccinology Approach
Multidrug-resistant Acinetobacter baumannii ( A. baumannii ) infections are becoming more prevalent all over the world. As a cost-effective and...
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In Silico Analysis and Immune Response of YaeT Protein Against Riemerella anatipestifer in Ducks
Riemerella anatipestifer ( RA ) is one of the most harmful bacterial pathogens in waterfowl and causes enormous economic loss worldwide. Due to weak...
