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Microdialysis techniques and microdialysis-based patient-near diagnostics
This article will debate the usefulness of POCT measurements and the contribution microdialysis can make to generating valuable information. A...
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Sensitive and Fast Detection of Monoamines and Their Metabolites by High-Performance Liquid Chromatography Coupled with an Electrochemical Detector (HPLC-ECD) Under Isocratic Conditions: Application to Intracerebral Microdialysis in Mice Treated by Fluoxetine and Atomoxetine
Neurotransmitters (NTs) play a crucial role in brain function and associated with various neurological and neuropsychiatric disorders. This study...
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Application of microdialysis combined with UHPLC-QTOF/MS to screen for endogenous metabolites in aquatic organisms as biomarkers of exposure to an emerging contaminant, triclosan
The detection of emerging contaminants (ECs) and understanding their ecotoxicity has brought new challenges to water pollution control. Triclosan...
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Brain distribution and metabolic profiling of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats investigated by UHPLC-HRMS/MS following peripheral administration
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is known to be a tobacco-specific N -nitrosamine and has peripheral carcinogenic properties. It...
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Robotic Affinity Purification of Soluble and Insoluble Recombinant Glutathione-S-Transferase Fusion Proteins
A completely automated purification of glutathione-S-transferase (GST) fusion proteins, either in soluble form or after renaturation of insoluble...
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A novel microemulsion-based isotonic perfusate modulated by Ringer’s solution for improved microdialysis recovery of liposoluble substances
BackgroundMicrodialysis is promising technique for dynamic microbiochemical sampling from tissues. However, the application of typical aqueous...
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Quick preparation of water-soluble perovskite nanocomposite via cetyltrimethylammonium bromide and its application
A good water-soluble and stable nanocomposite has been facilely prepared by the encapsulation of CsPbBr 3 QDs via cetyltrimethylammonium bromide and...
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Miniaturized probe on polymer SU-8 with array of individually addressable microelectrodes for electrochemical analysis in neural and other biological tissues
An SU-8 probe with an array of nine, individually addressable gold microband electrodes (100 μm long, 4 μm wide, separated by 4-μm gaps) was...
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Capillary Electrophoresis–Mass Spectrometry for the Direct Analysis of Metabolites in Highly Saline Samples Using In-Capillary Preconcentration
Capillary electrophoresis–mass spectrometry (CE–MS) is gaining interest for metabolomics studies because of its high separation efficiency,...
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Drug Delivery to the Brain: Physiological Concepts, Methodologies, and Approaches
An important property in any central nervous system (CNS) drug is the ability to cross into the brain and reach therapeutic concentrations at safe...
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Biological applications of microchip electrophoresis with amperometric detection: in vivo monitoring and cell analysis
Microchip electrophoresis with amperometric detection (ME-EC) is a useful tool for the determination of redox active compounds in complex biological...
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A Method to Collect Cerebrospinal Fluid from Mouse Cisterna Magna to Determine Extracellular Tau Levels
Despite being a cytoplasmic protein abundant in neurons, tau is detectable in various extracellular fluids. In addition to being passively released...
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Preclinical In Vivo Drug Development Studies: Limitations, Model Organisms, and Techniques
The process of drug discovery and development encompasses target identification, validation, assay development, identification of hits, lead...
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Spectroscopic Determination of Acetylcholine (ACh): A Representative Review
Acetylcholine (ACh) is one of the most crucial neurotransmitters of the cholinergic system found in vertebrates and invertebrates and is responsible...
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Role of Bioanalytical Chemistry in the Twenty-First Century
Bioanalytical chemistry is an ever-growing, vast, and exciting field where creative and dedicated practitioners have tackled important biological...
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Microfluidics-enabled mesenchymal stem cell derived Neuron like cell membrane coated nanoparticles inhibit inflammation and apoptosis for Parkinson’s Disease
Parkinson’s disease (PD) is the second largest group of neurodegenerative diseases, and its existing drug treatments are not satisfactory. Natural...
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Disease Influence on BBB Transport in Neurodegeneration
For the pharmacotherapy of neurodegenerative diseases, drugs must pass the blood–brain barrier (BBB). The BBB seems to play an important role in...
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Use of 3D printing to integrate microchip electrophoresis with amperometric detection
This paper describes the use of PolyJet 3D printing to fabricate microchip electrophoresis devices with integrated microwire electrodes for...
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Blood-to-Brain Drug Delivery Using Nanocarriers
Central nervous system (CNS) disorders represent a large, unmet medical need. CNS drug development is hampered by the restricted transport of drug...
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Pharmacokinetic Concepts in Brain Drug Delivery
This chapter presents the pharmacokinetic principles of blood-brain barrier (BBB) transport and the intra-brain distribution of small molecular...