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A remarkable change in inhibition potency and selectivity of isofagomine by simple N-modification
Herein, we present an alternative and elegant synthetic approach toward powerful β-glucosidase inhibitor isofagomine. Derivatizations of the ring...
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Age-related functional decline of human B cells
This study aimed to investigate the changes in B cell functional decline and antigen sensitization with aging using two Epstein Barr virus...
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Lactic acid bacteria in Asian fermented foods and their beneficial roles in human health
Fermented foods have been a staple in human diets for thousands of years, garnering attention for their health and medicinal benefits. Rich in lactic...
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Screening for functional IRESes using α-complementation system of β-galactosidase in Pichia pastoris
BackgroundPichia pastoris is becoming a promising chassis cell for metabolic engineering and synthetic biology after its whole genome and...
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Metabolism of a hybrid algal galactan by members of the human gut microbiome
Native porphyran is a hybrid of porphryan and agarose. As a common element of edible seaweed, this algal galactan is a frequent component of the...
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Annotating Multiple Prebiotic Synthesizing Capabilities Through Whole Genome Sequencing of Fusarium Strain HFK-74
In the present study, seven fungal isolates from effluent treatment plants were screened for the production of prebiotic fructooligosaccharide...
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Calcium-assisted sortase A cleavage of SUMOylated metallothionein constructs leads to high-yield production of human MT3
BackgroundMammalian metallothioneins (MTs) are small (6–7 kDa), intracellular, cysteine-rich, metal-binding proteins involved, inter alia, in the...
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Optimization of Saccharomyces cerevisiae α-galactosidase production and application in the degradation of raffinose family oligosaccharides
Backgroundα-Galactosidases are enzymes that act on galactosides present in many vegetables, mainly legumes and cereals, have growing importance with...
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Prebiotic properties of Bacillus coagulans MA-13: production of galactoside hydrolyzing enzymes and characterization of the transglycosylation properties of a GH42 β-galactosidase
BackgroundThe spore-forming lactic acid bacterium Bacillus coagulans MA-13 has been isolated from canned beans manufacturing and successfully...
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Technological Approaches to Improve Food Quality for Human Health
Nutrients and non-nutrients are highly variable, and, in some cases, unstable in food. Health-promoting components of food can be enhanced and...
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Nogo-B Silencing Expedites the Senescence of Platelet-Derived Growth Factor-BB-Induced Human Hepatic Stellate Cells Via Autophagy
Liver fibrosis is a severe liver pathology in response to chronic or iterative liver injury. Senescence has emerged as a protective mechanism against...
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Synbiotics: a New Route of Self-production and Applications to Human and Animal Health
Synbiotics are preparations in which prebiotics are added to probiotics to achieve superior performance and benefits on the host. A new route of...
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Biocompatibility Analysis of Biomass-Based Cosmetics for Human
The discovery of active ingredients from biomass has led to increased research in biomedical applications. Currently, the use of chemical components...
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Quantifying lysosomal glycosidase activity within cells using bis-acetal substrates
Understanding the function and regulation of enzymes within their physiologically relevant milieu requires quality tools that report on their...
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Sulfated glycan recognition by carbohydrate sulfatases of the human gut microbiota
Sulfated glycans are ubiquitous nutrient sources for microbial communities that have coevolved with eukaryotic hosts. Bacteria metabolize sulfated...
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Isomaltooligosaccharides utilization and genomic characterization of human infant anti-inflammatory Bifidobacterium longum and Bifidobacterium breve strains
This study was carried out to understand the probiotic features, ability to utilize non-digestible carbohydrates and comparative genomics of...
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Ceria-Zirconia nanoparticles reduce intracellular globotriaosylceramide accumulation and attenuate kidney injury by enhancing the autophagy flux in cellular and animal models of Fabry disease
BackgroundFabry disease (FD) is a lysosome storage disease (LSD) characterized by significantly reduced intracellular autophagy function. This...
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Leveraging Bioprocessing Strategies to Achieve the Simultaneous Extraction of Full-Fat Chickpea Flour Macronutrients and Enhance Protein and Carbohydrate Functionality
The concurrent extraction of lipids, proteins, and carbohydrates can be achieved by aqueous and enzymatic extraction processes, circumventing the low...
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Exploring the Potential of Microbial Biomolecules in Advancing Human Health and Environmental Sustainability
Microbial biomolecules have gained significant attention owing to their remarkable capacity for promoting advancements in human health and...
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Potentiality of Polyextremophilic Organisms in Bioremediation of Aromatic Hydrocarbons and Persistent Organic Pollutants: A Biotechnological Approach
Polyextremophiles are organisms that have adapted themselves to survive within habitats having different physicochemical conditions at extreme...