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The novel properties of Kluyveromyces marxianus glucose sensor/receptor repressor pathway and the construction of glucose repression-released strains
BackgroundGlucose repression in yeast leads to the sequential or diauxic utilization of mixed sugars and reduces the co-utilization of glucose and...
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Adaptation on xylose improves glucose–xylose co-utilization and ethanol production in a carbon catabolite repression (CCR) compromised ethanologenic strain
BackgroundSugar hydrolysates from lignocellulosic biomass are majorly composed of glucose and xylose that can be fermented to biofuels. Bacteria,...
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XylR Overexpression in Escherichia coli Alleviated Transcriptional Repression by Arabinose and Enhanced Xylitol Bioproduction from Xylose Mother Liquor
Xylitol is a polyol widely used in food, pharmaceuticals, and light industries. It is currently produced through the chemical catalytic hydrogenation...
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The arabinose transporter MtLat-1 is involved in hemicellulase repression as a pentose transceptor in Myceliophthora thermophila
BackgroundFilamentous fungi possess an array of secreted enzymes to depolymerize the structural polysaccharide components of plant biomass. Sugar...
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Engineering co-utilization of glucose and xylose for chemical overproduction from lignocellulose
Bio-refining lignocellulose could provide a sustainable supply of fuels and fine chemicals; however, the challenges associated with the...
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Mechanism of differential expression of β-glucosidase genes in functional microbial communities in response to carbon catabolite repression
Backgroundβ-Glucosidase is the rate-limiting enzyme of cellulose degradation. It has been stipulated and established that β-glucosidase-producing...
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Baicalein facilitates gastric cancer cell apoptosis by triggering endoplasmic reticulum stress via repression of the PI3K/AKT pathway
ObjectiveGastric cancer (GC) remains a prevailing threat to life. Baicalein exhibits anti-cancer properties. This study estimated the mechanism of...
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Development of an auto-inducible expression system by nitrogen sources switching based on the nitrogen catabolite repression regulation
BackgroundThe construction of protein expression systems is mainly focused on carbon catabolite repression and quorum-sensing systems. However, each...
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When metabolic prowess is too much of a good thing: how carbon catabolite repression and metabolic versatility impede production of esterified α,ω-diols in Pseudomonas putida KT2440
BackgroundMedium-chain-length α,ω-diols (mcl-diols) are important building blocks in polymer production. Recently, microbial mcl-diol production from...
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Lipid Accumulation by Snf-β Engineered Mucor circinelloides Strains on Glucose and Xylose
Sucrose non-fermenting 1 (SNF1) protein kinase plays the regulatory roles in the utilization of selective carbon sources and lipid metabolism....
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Disruption of alpha-tubulin releases carbon catabolite repression and enhances enzyme production in Trichoderma reesei even in the presence of glucose
BackgroundTrichoderma reesei is a filamentous fungus that is important as an industrial producer of cellulases and hemicellulases due to its high...
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Carbon catabolite repression involves physical interaction of the transcription factor CRE1/CreA and the Tup1–Cyc8 complex in Penicillium oxalicum and Trichoderma reesei
BackgroundCellulolytic enzyme production in filamentous fungi requires a release from carbon catabolite repression (CCR). The protein CRE1/CreA...
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Effect of deregulation of repressor-specific carbon catabolite repression on carbon source consumption in Escherichia coli
Escherichia coli has been used as a host to construct the cell factory for biobased production of chemicals from renewable feedstocks. Because...
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Co-utilization of glucose and xylose for the production of poly-β-hydroxybutyrate (PHB) by Sphingomonas sanxanigenens NX02
BackgroundPoly-β-hydroxybutyrate (PHB), produced by a variety of microbial organisms, is a good substitute for petrochemically derived plastics due...
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Using phosphoglucose isomerase-deficient (pgi1Δ) Saccharomyces cerevisiae to map the impact of sugar phosphate levels on d-glucose and d-xylose sensing
BackgroundDespite decades of engineering efforts, recombinant Saccharomyces cerevisiae are still less efficient at converting d -xylose sugar to...
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Enhanced biosurfactant production by Bacillus subtilis SPB1 using developed fed-batch fermentation: effects of glucose levels and feeding systems
Biosurfactants stand for highly useful and promising compounds. They basically serve for a variety of applications in multiple industries and aspects...
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Metabolic engineering of yeast for the production of carbohydrate-derived foods and chemicals from C1–3 molecules
The increase in population-related and environmental issues has emphasized the need for more efficient and sustainable production strategies for...
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Inducer-free recombinant protein production in Trichoderma reesei: secretory production of endogenous enzymes and heterologous nanobodies using glucose as the sole carbon source
BackgroundThe filamentous fungus Trichoderma reesei has been used as a host organism for the production of lignocellulosic biomass-degrading...
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Glucose consumption rate-dependent transcriptome profiling of Escherichia coli provides insight on performance as microbial factories
BackgroundThe modification of glucose import capacity is an engineering strategy that has been shown to improve the characteristics of Escherichia...
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Engineering transcriptional regulation of pentose metabolism in Rhodosporidium toruloides for improved conversion of xylose to bioproducts
Efficient conversion of pentose sugars remains a significant barrier to the replacement of petroleum-derived chemicals with plant biomass-derived...
