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New insights in the opening mechanism of the heart-type fatty acid binding protein in its apo form (apo-FABP3)
The apo-FABP3 was simulated through molecular dynamics at different temperatures—close to the physiological—allowing for the establishment of a new...
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Network pharmacology-based analysis of signaling pathways of an anti-osteoporotic triterpenoid from Acyranthes bidentata Blume root
In Korea folk remedies, Acyranthes bidentata Blume is a functional food plant to treat bone diseases; especially, its roots have been used to...
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Identification of Subproteomic Markers for Skeletal Muscle Profiling
The biochemical and cell biological profiling of contractile fiber types and subcellular structures plays a central role in basic and applied...
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Proteomics Analysis of Meat to Identify Goat Intramuscular Fat Deposits Potential Biomarkers
Intramuscular fat (IMF) is a central attribute of goat nutrition qualities and consumers’ choice. Here, we reported potential markers of IMF deposits...
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BMP11 Negatively Regulates Lipid Metabolism in C2C12 Muscle Cells
Muscle tissue influences energy and protein metabolism throughout the body. Earlier reports demonstrated that bone morphogenetic protein 11 (BMP11)...
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Introduction of Aptamer, SELEX, and Different SELEX Variants
In recent years, molecular diagnostic and therapeutic techniques in the field of medical science have been developed rapidly. It is necessary and...
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Characterization of the Immune Infiltration Landscape and Identification of Prognostic Biomarkers for Esophageal Cancer
Immunotherapy is an effective treatment for esophageal cancer (ESCA) patients. However, there are no dependable markers for predicting prognosis and...
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Single-nucleus and bulk RNA sequencing reveal cellular and transcriptional mechanisms underlying lipid dynamics in high marbled pork
Pork is the most consumed meat in the world, and its quality is associated with human health. Intramuscular fat (IMF) deposition (also called...
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Exploring the Role of Ferroptosis-Related Circular RNAs in Subarachnoid Hemorrhage
Subarachnoid hemorrhage (SAH) is a devastating cerebrovascular event associated with high mortality and significant morbidity. Recent studies have...
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Absolute Quantitative Targeted Proteomics Assays for Plasma Proteins
Preclinical and clinical trials require rapid, precise, and multiplexed analytical methods to characterize the complex samples and to allow...
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Peptide-Based Therapeutics and Drug Delivery Systems
Peptides are functional biomolecules that hold great potential for the discovery of new therapeutics and drug delivery systems. Structurally, these...
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Tracing the Anti-cancer Mechanism of Pleurotus osteratus by the Integrative Approach of Network Pharmacology and Experimental Studies
The present study identified the probable mechanism behind the anti-cancer activity of the hexane fraction of Pleurotus osteratus (HFPO) using...
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Low Molecular Pectin Inhibited the Lipid Accumulation by Upregulation of METTL7B
Inhibition of lipid accumulation is the key step to prevent nonalcoholic fatty liver (NAFL) progressing to nonalcoholic steatohepatitis. We aimed to...
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Milk-derived mammary epithelial cells as non-invasive source to define stage-specific abundance of milk protein and fat synthesis transcripts in native Sahiwal cows and Murrah buffaloes
The molecular physiology of milk production of two important dairy species; Sahiwal cows ( Bos indicus ) and Murrah buffaloes ( Bubalus bubalis ) are not...
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Classes and Applications of Cell-Penetrating Peptides
Possibilities for classificationClasses of CPPs based on their type of origin, biochemical properties, and physico-chemical...
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Analysis of the role of perfusion, mechanical, and electrical stimulation in bioreactors for cardiac tissue engineering
Since cardiovascular diseases (CVDs) are globally one of the leading causes of death, of which myocardial infarction (MI) can cause irreversible...
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Combinatorial Electrophoresis and Mass Spectrometry-Based Proteomics in Breast Milk for Breast Cancer Biomarker Discovery
Innovations in approaches for early detection and individual risk assessment of different cancers, including breast cancer (BC), are needed to reduce...
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Comparison of liver transcriptome from high- and low-intramuscular fat Chaohu ducks provided additional candidate genes for lipid selection
The meat quality of ducks is closely related to the intramuscular fat (IMF) content. This study explored the candidate regulatory genes of IMF...
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Nanomedicine-based technologies and novel biomarkers for the diagnosis and treatment of Alzheimer’s disease: from current to future challenges
Increasing life expectancy has led to an aging population, which has consequently increased the prevalence of dementia. Alzheimer's disease (AD), the...
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α-Lipoic acid ameliorates mitochondrial impairment and reverses apoptosis in FABP3-overexpressing embryonic cancer cells
Fatty acid-binding protein 3 (FABP3) is a low molecular weight protein with distinct tissue distribution, which may play an important role in fatty...