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Genetically programmed cell-based synthesis of non-natural peptide and depsipeptide macrocycles
The direct genetically encoded cell-based synthesis of non-natural peptide and depsipeptide macrocycles is an outstanding challenge. Here we...
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Structural basis of keto acid utilization in nonribosomal depsipeptide synthesis
Nonribosomal depsipeptides are natural products composed of amino and hydroxy acid residues. The hydroxy acid residues often derive from α-keto...
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Synthesis of Macrocyclic Depsipeptides via the Passerini–Click Reaction Strategy
AbstractA combination of the Passerini reaction and copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC, click reaction) was used to synthesize...
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Three Methods for the Solution Phase Synthesis of Cyclic Peptides
Cyclic peptides, which often exhibit interesting biological properties, can be obtained by macrolactamization of adequately protected linear peptide...
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Bakterientoxine
Exotoxine, die von lebenden, grampositiven Bakterien erzeugt werden, unterscheiden sich von Endotoxinen, die als Bestandteile der gramnegativen...
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Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis
The antimicrobial resistance crisis requires the introduction of novel antibiotics. The use of conventional broad-spectrum compounds selects for...
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Small Molecules as Promising Tool for Targeted Cancer Therapies: An Overview of the Twenty-First Century
It has been an established fact now from more than 50 years that genetic differences among individuals are responsible for inter-individual...
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O-to-O acyl transfer for epimerization-free peptide C-terminal salicylaldehyde ester synthesis
Peptide salicylaldehyde esters are the requisite coupling partner in Ser/Thr ligation reactions towards chemical protein synthesis. In general, it...
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Aminosäuren, Peptide und Proteine
Die Eiweiße oder Proteine (Polypeptide) sind hochmolekulare Naturstoffe (Molekülmasse...
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Signal peptide mimicry primes Sec61 for client-selective inhibition
Preventing the biogenesis of disease-relevant proteins is an attractive therapeutic strategy, but attempts to target essential protein biogenesis...
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Hydroxytryptophan biosynthesis by a family of heme-dependent enzymes in bacteria
Hydroxytryptophan serves as a chemical precursor to a variety of bioactive specialized metabolites, including the human neurotransmitter serotonin...
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A comprehensive method to elucidate pyoverdines produced by fluorescent Pseudomonas spp. by UHPLC-HR-MS/MS
Microbial secondary metabolites represent a rich source for drug discovery, plant protective agents, and biotechnologically relevant compounds. Among...
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Antibiotics That Inhibit Cell Wall Synthesis
Structure of the bacterial cell wall, the metabolic pathway for the biosynthesis of the cell wall, and various antibiotics affecting the different...
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3D Printing of Hydrogel-Based Biocompatible Materials
Abstract3D printing is a promising method for fabricating structures of complex shape from biomaterials for restoration and regeneration of bone and...
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Methods of Screening and Applications of Biosurfactants Produced by Actinomycetes
Actinomycetes are the Gram-positive, unicellular, spore-producing, nonmotile, oval-shaped, facultative anaerobic bacteria. These organisms appear...
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One chiral fingerprint to find them all
AbstractMolecular fingerprints are indispensable tools in cheminformatics. However, stereochemistry is generally not considered, which is problematic...
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Microbial Bioactive Components: Sources, Applications, and Sustainability
Microbial-based bioactive metabolic compounds are a pool of metabolites that have confident positive effects on environment, humans, plants, and...