Search
Search Results
-
Antiplatelet effect of cudraxanthone B is related to inhibition of calcium mobilization, αIIbβ3 activation, and clot retraction
Cudrania tricuspidata ( C. tricuspidata ) is widespread throughout Asia and has known to have various physiological activities such as, inflammation,...
-
Assessment of Induction and Destruction of Thrombi
Microbial infection may increase the risk of thrombosis. Infection associated thrombosis is importantly mediated by inflammation. Inflammation...
-
Immobilization of Protease KHB3 onto Magnetic Metal–Organic Frameworks and Investigation of Its Biotechnological Applications
Recently, enzyme immobilization via self-assembly of magnetic metal–organic frameworks (mMOFs) has attracted attention for researchers. In this...
-
Prevalence of Factor V Leiden (FVL, G1691A) and F-II (G20210A) Mutations in Jordanian Atherosclerotic Patients
AbstractAtherosclerosis is a disease of blood vessels which is caused by inherited and acquired factors and leads to different complications in the...
-
Purification, characterization and fibrino(geno)lytic activity of cysteine protease from Tabernaemontana divaricata latex
Protease was isolated and purified from Tabernaemontana divaricata latex and its hemostatic potential was analyzed. Crude latex enzyme was purified...
-
Dynamics of Changes in the Secondary Structure of Fibrin under the Adrenaline Influence
AbstractIt is known that intermolecular interactions, spatial orientation of molecules, changes in protein structure, and hydrophilicity largely...
-
P-Selectin mediates targeting of a self-assembling phototherapeutic nanovehicle enclosing dipyridamole for managing thromboses
Thrombotic vascular disorders, specifically thromboembolisms, have a significant detrimental effect on public health. Despite the numerous...
-
Cross-linked Enzyme Aggregates of Fibrinolytic Protease BC1 Immobilized on Magnetic Chitosan Nanoparticles (CLEAs-Fib-mChi): Synthesis, Purification, and Characterization
Bacterial fibrinolytic proteases achieved more attention in the prevention and treatment of cardiovascular diseases, so purification,...
-
Lysine-oligoether-modified electrospun poly(carbonate urethane) matrices for improving hemocompatibility response
Although biomedical devices have greatly evolved, none of the materials that have been used to date are able to meet all the hemocompatibility...
-
Artocarpesin acts on human platelet aggregation through inhibition of cyclic nucleotides and MAPKs
The cardiovascular diseases (CVDs) are becoming a critical threat to our lives in these years. It is now widely accepted that platelets play an...
-
Phenolics profiling and biological activities of different solvent extracts from aerial parts of wild thyme (Thymus vulgaris L.)
The current research work appraises the variation in antioxidant, antibacterial and cytotoxic potential of thyme extracts in relation to different...
-
Secretome Profile of Leukocyte-Platelet-Rich Fibrin (L-PRF) Membranes
In the last years, platelet concentrates such as leukocyte-platelet-rich fibrin (L-PRF) have been used in different clinical scenarios as a huge...
-
Redox-responsive peptide-based complex coacervates as delivery vehicles with controlled release of proteinous drugs
Proteinous drugs are highly promising therapeutics to treat various diseases. However, they suffer from limited circulation times and severe...
-
A nano-Liposomal formulation potentiates antioxidant, anti-inflammatory, and fibrinolytic activities of Allolobophora caliginosa coelomic fluid: formulation and characterization
BackgroundCoelomic fluid, a pharmacologically active compound in earthworms, exhibits a range of biological activities, including antioxidant,...
-
Biological potential of vinyl/allyl substituted imidazole-based N-heterocyclic carbene adducts: synthesis, spectral and X-ray crystallographic structural characteristics
This manuscript describes the synthesis of three new selenium vinyl/allyl adducts (IV–VI), which incorporate imidazolium- N -heterocyclic carbene...
-
Thrombolytic therapy based on lyophilized platelet-derived nanocarriers for ischemic stroke
BackgroundIntravenous administration of fibrinolytic drugs, such as recombinant tissue plasminogen activator (rtPA) is the standard treatment of...
-
Phytochemistry and Pharmacology of Aromatic Medicinal Plant Commiphora caudata (Wight & Arn.) Engl.
Commiphora caudate (Wight & Arn.) Engl. (family: Burseraceae) commonly called South-Indian Commiphora is a deciduous tree found in Peninsular India...
-
Biomimetic platelet-camouflaged drug-loaded polypyrrole for the precise targeted antithrombotic therapy
Lower extremity deep venous thrombosis (LEDVT) affects patient’s quality of life for a long time, and even causes pulmonary embolism, which threatens...
-
Chitosan–Platelet Interactions
Since chitosan was identified as a hemostatic agent in the 1980s, “chitosan and platelets” has developed into a topic of intense interest. This...
-
Facile One-Pot Approach to the Synthesis of Alkyl Piperazine-1-carbodithioates as Hemolytic and Thrombolytic Agents
AbstractA polyethylene glycol (PEG)-promoted methodology has been utilized for synthesis of piperazine-based dithiocarbamates. One-pot reaction of N -...
