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CRISPR-Cas Systems: Programmable Nuclease Revolutionizing the Molecular Diagnosis
CRISPR-Cas system has evolved as a highly preferred genetic engineering tool to perform target gene manipulation via alteration of the guide RNA...
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Aptamer-based CRISPR-Cas powered diagnostics of diverse biomarkers and small molecule targets
CRISPR-Cas systems have been widely used in genome editing and transcriptional regulation. Recently, CRISPR-Cas effectors are adopted for biosensor...
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CRISPR/Cas Systems: A New Biomedical and Agricultural Diagnostic Devices for Viral Diseases
Researchers have been lured to the development of a point-of-care testing system by field-based simple diagnostic technologies, such as recombinase...
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A universal CRISPR-Cas14a responsive triple-sensitized upconversion photoelectrochemical sensor
It has recently been discovered that, like other members of the Cas family (12a and 13a), the clustered regularly interspaced short palindrome repeat...
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Enhancement and inactivation effect of CRISPR/Cas12a via extending hairpin activators for detection of transcription factors
An enhancement effect for the activation of CRISPR/Cas12a (CRISPR = clustered regularly interspaced short palindromic repeats;...
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Structures, mechanisms and applications of RNA-centric CRISPR–Cas13
Prokaryotes are equipped with a variety of resistance strategies to survive frequent viral attacks or invading mobile genetic elements. Among these,...
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CRISPR-Cas System for RNA Detection and Imaging
The system of clustered regularly interspaced short palindromic repeats(CRISPR) and CRISPR-associated endonucleases(Cas) have been widely used in...
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Electrochemical biosensor strategy combining DNA entropy-driven technology to activate CRISPR-Cas13a activity and triple-stranded nucleic acids to detect SARS-CoV-2 RdRp gene
By merging DNA entropy-driven technology with triple-stranded nucleic acids in an electrochemical biosensor to detect the SARS-CoV-2 RdRp gene, we...
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Systems Medicine for Precise Targeting of Glioblastoma
Glioblastoma (GBM) is a malignant cancer that is fatal even after standard therapy and the effects of current available therapeutics are not...
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CRISPR-Cas13a-Triggered DNAzyme Signal Amplification-Based Colorimetric miRNA Detection Method and Its Application in Evaluating the Anxiety
The development of a bio-sensing strategy based on CRISPR/Cas that is exceptionally sensitive is crucial for the identification of trace molecules....
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The SHERLOCK Platform: An Insight into Advances in Viral Disease Diagnosis
Persistence and prevalence of microbial diseases (pandemics, epidemics) is the most alarming threats to the human resulting in huge health and...
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Applications of Graphene Field Effect Biosensors for Biological Sensing
This chapter provides a comprehensive overview of the principles, applications, and advancements in graphene field-effect transistor (gFET)...
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Nano-Based Robotic Technologies for Plant Disease Diagnosis
Plant diseases continue to pose a threat to key commercial plants and result in large economic losses across the world. Global food security is also...
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Rapid and Finely-Tuned Expression for Deployable Sensing Applications
Organisms from across the tree of life have evolved highly efficient mechanisms for sensing molecules of interest using biomolecular machinery that...
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Recent Advances in Electrochemical and Nanophotonic Biosensors for SARS-CoV-2 Detection
The contagious respiratory illness coronavirus disease 2019 (COVID-19) has had an unprecedented impact on both global health and society, causing a...
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Towards application of CRISPR-Cas12a in the design of modern viral DNA detection tools (Review)
Early detection of viral pathogens by DNA-sensors in clinical samples, contaminated foods, soil or water can dramatically improve clinical outcomes...
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Applications of Genome Editing in Extremophiles
The member of bacteria, archaea, and eukarya comes under the umbrella of extremophiles. Extremophiles can survive in the extremely harsh conditions...
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Nanomaterials-assisted gene editing and synthetic biology for optimizing the treatment of pulmonary diseases
The use of nanomaterials in gene editing and synthetic biology has emerged as a pivotal strategy in the pursuit of refined treatment methodologies...
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Expanding the RNA- and RNP-Based Regulatory World in Mammalian Cells
RNA and RNA-protein (RNP) complexes play critical roles in controlling gene expression and cellular functions. Not only does RNA help decode genetic...
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Development of practical techniques for simultaneous detection and distinction of current and emerging SARS-CoV-2 variants
Countless individuals have fallen victim to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and have generated antibodies, reducing...
