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Structures of the human cholecystokinin receptors bound to agonists and antagonists
Cholecystokinin receptors, CCK A R and CCK B R, are important neurointestinal peptide hormone receptors and play a vital role in food intake and appetite...
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Construction and application of covalently bonded CD147 cell membrane chromatography model based on polystyrene microspheres
In this study, a novel cell membrane chromatography (CMC) model was developed to investigate cluster of differentiation 147 (CD147) targeted...
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Gene Variants Involved in the Etiopathogenesis of Eating Disorders: Neuropeptides, Neurotransmitters, Hormones, and Their Receptors
Eating disorders have a deep social, mental, and physical impact and multifactorial origins, but the strong genetic component is universally...
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Development of target-based cell membrane affinity ultrafiltration technology for a simplified approach to discovering potential bioactive compounds in natural products
Target-based drug discovery technology based on cell membrane targets has gained significant traction and has been steadily advancing. However,...
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A peptide derived from interleukin-10 exhibits potential anticancer activity and can facilitate cell targeting of gold nanoparticles loaded with anticancer therapeutics
Human interleukin-10 (IL-10) is an immunosuppressive and anti-inflammatory cytokine, and its expression is upregulated in tumor tissues and serum...
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Conformational Aspects and Interaction Studies of Heterocyclic Drugs
Drug discoveries require the iterative synthesis—along with structural studies—of numerous individual analogues of biologically and medicinally...
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Gene Variants Involved in the Etiopathogenesis of Eating Disorders: Neuropeptides, Neurotransmitters, Hormones, and Their Receptors
Eating disorders have a deep social, mental, and physical impact and multifactorial origins, but the strong genetic component is universally...
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Expression of proline-rich protein 15 in breast cancer and its effect on cell biological function
PRR15, a member of the proline-rich protein family, has been linked to a better prognosis in breast cancer patients and is highly expressed in a...
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Rhenium and Technetium Complexes Anchored by Phosphines and Scorpionates for Radiopharmaceutical Applications
This review presents a comprehensive overview of the most significant developments in the chemistry of technetium and rhenium complexes anchored by...
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Ethanol Extract of Anacyclus pyrethrum Root Ameliorates Cough-Variant Asthma Through the TLR4/NF-κB Pathway and Wnt/β-Catenin Pathway
Cough-variant asthma (CVA) has been recognized as the initial stage or pre-asthmatic state of classic asthma, which characterized by cough as the...
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Nutrition and Noncommunicable Disorders
Traditionally nutritional disorders are the pathophysiological changes associated with malnutrition that occur because of an increase or a decrease...
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Quinazoline Alkaloids and Related Chemistry
Recent progress in quinazoline alkaloids and related chemistry was reviewed focusing on developments of the synthetic methodologies and their...
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Coordinated modulation of long non-coding RNA ASBEL and curcumin co-delivery through multicomponent nanocomplexes for synchronous triple-negative breast cancer theranostics
BackgroundAbnormally regulated long non-coding RNAs (lncRNAs) functions in cancer emphasize their potential to serve as potential targets for cancer...
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Protective Effects of Ginkgolide on a Cellular Model of Alzheimer’s Disease via Suppression of the NF-κB Signaling Pathway
NF-κB signaling has been reported to play a key regulatory role in the pathogenesis of Alzheimer’s disease (AD). The purpose of this study is to...
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Structure‐based identification of dual ligands at the A2AR and PDE10A with anti‐proliferative effects in lung cancer cell‐lines
Enhanced/prolonged cAMP signalling has been suggested as a suppressor of cancer proliferation. Interestingly, two key modulators that elevate cAMP,...
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Long-acting anti-inflammatory injectable DEX-Gel with sustained release and self-healing properties regulates TH1/TH2 immune balance for minimally invasive treatment of allergic rhinitis
BackgroundAllergic rhinitis (AR) is a prevalent immune-related allergic disease, and corticosteroid nasal sprays serve as the primary treatment for...
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The anti-tumor and renoprotection study of E-[c(RGDfK)2]/folic acid co-modified nanostructured lipid carrier loaded with doxorubicin hydrochloride/salvianolic acid A
BackgroundPoor in vivo targeting of tumors by chemotherapeutic drugs reduces their anti-cancer efficacy in the clinic. The discovery of...
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Dietary Carbohydrates and Health
Among the four major biomolecules found in all living systems, the most abundant are the carbohydrates (carbo-carbon; hydro-water). They are called...
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An Overview on Biological Importance of Pyrrolone and Pyrrolidinone Derivatives as Promising Scaffolds
AbstractPyrrolones and pyrrolidinones are five-membered heterocycles and are versatile lead compounds for designing powerful bioactive agents....