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An Approach for Antigen-Agnostic Identification of Virus-Like Particle-Displayed Epitopes that Engage Specific Antibody V Gene Regions
Antibody complementarity determining regions (CDRs) participate in antigen recognition, but not all participate equally in antigen binding. Here we...
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Probing antibody surface density and analyte antigen incubation time as dominant parameters influencing the antibody-antigen recognition events of a non-faradaic and diffusion-restricted electrochemical immunosensor
Electrochemical sensors based on antibody-antigen recognition events are commonly used for the rapid, label-free, and sensitive detection of various...
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Exploiting the Role of Features for Antigens-Antibodies Interaction Site Prediction
Antibodies are a class of proteins that recognize and neutralize pathogens by binding to their antigens. They are the most significant category of...
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Engineering Homogeneous Photoactive Antibody Fragments
Genetically encoded site-specifically incorporated noncanonical amino acids (ncAAs) have been used to modulate properties of several proteins. Here,...
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Lateral Flow Assays for COVID-19
Rapid tests are essential tools for monitoring and containing the COVID-19 pandemic. Lateral flow assays (LFAs) have been introduced for the...
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Complex Process-Related Impurity Profiles
Every manufactured human medicine contains residual impurities associated with its manufacturing process. Patient safety risk associated with the...
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A label-free aptasensing method for detecting SARS-CoV-2 virus antigen by using dumbbell probe-mediated circle-to-circle amplification
Controlling the spread of pathogen requires an efficient and accurate diagnosis. Compared with nucleic acid and antibody detection, antigen assays...
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CD4+ T Cell Epitope Identification from Complex Parasite Antigen Mixtures
Antigen complexity represents a major challenge for scoring CD4+ T cell immunogenicity, a key hallmark of immunity and with great potential to...
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Antifouling strategies for electrochemical sensing in complex biological media
Surface fouling poses a significant challenge that restricts the analytical performance of electrochemical sensors in both in vitro and in vivo...
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In silico identification of new inhibitors for βeta-2-glycoprotein I as a major antigen in antiphospholipid antibody syndrome
Beta 2 glycoprotein I (β2GPI) is a major antigen for autoantibodies present in antiphospholipid antibody syndrome (APS). β2GPI is a single...
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Development and Characterization of Guinea Pig Anti-Insulin Polyclonal Antibody
Development and characterization of guinea pig anti-insulin polyclonal antibody against a target-specific insulin antigen. In India, an insulin...
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Development of a chemiluminescence assay for tissue plasminogen activator inhibitor complex and its applicability to gastric cancer
BackgroundVenous thromboembolism (VTE), is a noteworthy complication in individuals with gastric cancer, but the current diagnosis and treatment...
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Detection of Escherichia coli in Food Samples by Magnetosome-based Biosensor
The rising cases of food poisoning and traveler’s diarrhea through Escherichia coli infection are a global concern. Magnetosome is biogenic magnetic...
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Design and Purification of Tag/Catcher AP205-Based Capsid Virus-Like Particle Vaccines
Capsid virus-like particles (cVLPs), assembled from viral coat proteins, are used as therapeutic cargo delivery vehicles as well as molecular...
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Enhancing antibody affinity through experimental sampling of non-deleterious CDR mutations predicted by machine learning
The application of machine learning (ML) models to optimize antibody affinity to an antigen is gaining prominence. Unfortunately, the small and...
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Understanding the Specific Implications of Amino Acids in the Antibody Development
As the demand for immunotherapy to treat and manage cancers, infectious diseases and other disorders grows, a comprehensive understanding of amino...
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Electrochemical Immunosensor for Diagnosis of COVID-19
An immunosensor is a biosensor that detects antigen interactions using a particular antibody bound on the transducer’s surface. These biosensors have...
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Quantitative detection of urinary bladder cancer antigen via peptide-immobilized magnetic bead-based SERS probe
Antibody pairing is a difficult step in develo** all immune-sandwich assay for antigen detection. Urinary bladder cancer (UBC) antigen is a typical...
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Introduction of multilayered quantum dot nanobeads into competitive lateral flow assays for ultrasensitive and quantitative monitoring of pesticides in complex samples
A competitive fluorescent lateral flow assay (CFLFA) is proposed for direct, ultrasensitive, quantitative detection of common pesticides imidacloprid...
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Production of a Ribosome-Displayed Mouse scFv Antibody Against CD133, Analysis of Its Molecular Docking, and Molecular Dynamic Simulations of Their Interactions
The pentaspan transmembrane glycoprotein CD133, prominin-1, is expressed in cancer stem cells in many tumors and is promising as a novel target for...
