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Identification of Protein-Coding Gene Structure and Protein-Related Genes and Their Splicing Sites in Kidney Stone Disease: A Protein Big Data Analysis
The study of protein-coding gene structure and protein-related genes in kidney stone disease is used for accurate identification of splicing sites...
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Insight into the mechanism of molecular recognition between human Integrin-Linked Kinase and Cpd22 and its implication at atomic level
Pseudokinases have received increasing attention over the past decade because of their role in different physiological phenomena. Although...
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Checkpoint kinase 2 controls insulin secretion and glucose homeostasis
After the discovery of insulin, a century ago, extensive work has been done to unravel the molecular network regulating insulin secretion. Here we...
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Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors
Bivalent molecules consisting of groups connected through bridging linkers often exhibit strong target binding and unique biological effects....
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Molecular docking studies of natural immunomodulators indicate their interactions with the CD40L of CD40/CD40L pathway and CSF1R kinase domain of microglia
Natural products have proved beneficial in reducing neuroinflammation in neurological diseases. Their impacts have also been associated with the...
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Synthesis and Molecular Docking Study of Novel Pyrazole-Integrated 1,3,4-Oxadiazole Derivatives as Potential Cyclin-Dependent Kinase 2 Inhibitors
AbstractA series of novel pyrazole-integrated 1,3,4-oxadiazole derivatives have been synthesized and characterized by 1 H and 13 C NMR, IR, and mass...
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Antioxidant and angiotensin-I-converting enzyme (ACE-I) inhibitory activities of protein hydrolysates derived from water buffalo (Bubalus bubalis) liver
In the current study, we attempted to use ginger as a novel and natural source of protease in comparison with other commercially available enzymes to...
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Phosphorylation of Tau Protein by CDK2/cyclin A and GSK3β Recombinant Kinases: Analysis of Phosphorylation Patterns by Nuclear Magnetic Resonance Spectroscopy
Posttranslational modifications (PTMs) of proteins can be investigated by Nuclear Magnetic Resonance (NMR) spectroscopy as a powerful analytical tool...
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Exploration and augmentation of pharmacological space via adversarial auto-encoder model for facilitating kinase-centric drug development
Predicting compound–protein interactions (CPIs) is of great importance for drug discovery and repositioning, yet still challenging mainly due to the...
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A Streptomyces-Based Cell-Free Protein Synthesis System for High-Level Protein Expression
With the rapid development of cell-free biotechnology, more and more cell-free protein synthesis (CFPS) systems have been established and optimized...
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Evaluation of pea/rice and amylopectin/chromium as an alternative protein source to improve muscle protein synthesis in rats
BackgroundA preclinical study reported that the combination of an amylopectin/chromium complex (ACr) of branched-chain amino acids (BCAA)...
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Interaction of Tau with G-Protein-Coupled Purinergic P2Y12 Receptor by Molecular Docking and Molecular Dynamic Simulation
Alzheimer’s disease, a progressive neurological disorder, is characterized by the accumulation of neurofibrillary tangles and senile plaques by Tau...
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pSILAC-Based Determination of Cellular Protein Sorting into Extracellular Vesicles
The protein cargo of extracellular vesicles (EVs) determines their impact on recipient cell types and the downstream effects on biological function....
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Electron transfer in protein modifications: from detection to imaging
Signal pathways participate in vital biological processes and regulate complex life activities through protein modifications. Protein modifications...
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Vesicle-associated membrane protein 8 knockdown exerts anti-proliferative, pro-apoptotic, anti-autophagic, and pro-ferroptotic effects on colorectal cancer cells by inhibition of the JAK/STAT3 pathway
Vesicle-associated membrane protein 8 (VAMP8), a soluble n-ethylmaleimide-sensitive factor receptor protein, acts as an oncogenic gene in the...
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The Effect of Structural Analogues of Etimizole on Protein Kinase CK2, Protein Phosphorylation, and Transcription of Chromatin in Rat Cortical and Hippocampal Neurons
Abstract—The multifunctional protein kinase CK2 is an important enzyme in the nervous system. The nuclear forms of CK2 regulate chromatin structure...
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Enhancement of protein production in Aspergillus niger by engineering the antioxidant defense metabolism
BackgroundResearch on protein production holds significant importance in the advancement of food technology, agriculture, pharmaceuticals, and...
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Prediction of human protein interactome of dengue virus non-structural protein 5 (NS5) and its downstream immunological implications
The non-structural protein 5 (NS5) is the most conserved protein among flaviviruses, a family that includes the dengue virus. It functions both as an...
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Microbial Protein Elicitors in Plant Defense
Plant-microbe interactions are inevitable and determine whether the relationship is beneficial or pathogenic. Microbes secrete proteins that...
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Pervasive transcriptome interactions of protein-targeted drugs
The off-target toxicity of drugs targeted to proteins imparts substantial health and economic costs. Proteome interaction studies can reveal...
