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Synthesis, cytotoxicity, and docking based analysis of acridone-N-acetamides as AKT kinase inhibitors
The primary goal of this study is to synthesize and characterize N -substituted Acetamido derivatives of acridone, where the acetamido moiety has been...
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Differential Protein Expression in Response to Varlitinib Treatment in Oral Cancer Cell Line: an In Vitro Therapeutic Approach
Epidermal growth factor receptor (EGFR) is the most frequently overexpressed receptor histologically exhibited by oral squamous cell carcinoma (OSCC)...
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Both levoglucosan kinase activity and transport capacity limit the utilization of levoglucosan in Saccharomyces cerevisiae
Manufacturing fuels and chemicals from cellulose materials is a promising strategy to achieve carbon neutralization goals. In addition to the...
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Investigation of the inhibitory behavior of XFE and mitoxantrone molecules in interaction with AKT1 protein: a molecular dynamics simulation study
The PI3K/Akt/mTOR pathway is one of the important pathways in many cancers. Akt is a serine-threonine kinase protein identified as a drug target for...
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Determination of pKa Values for Some Tyrosine Kinase Inhibitors Using the Reversed-Phase Liquid Chromatography
The drug dissociation constant (p K a ) describes the ionization/protonation states. This physicochemical feature has a direct effect on the ADME...
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IRES-mediated Pichia pastoris cell-free protein synthesis
Cell-free protein synthesis (CFPS) system is an ideal platform for fast and convenient protein research and has been used for macromolecular...
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Multi-carbon dots and aptamer based signal amplification ratiometric fluorescence probe for protein tyrosine kinase 7 detection
BackgroundProtein tyrosine kinase 7 (PTK 7) is a membrane receptor, which can be found in various kinds of cancers. In view of this, detection of PTK...
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Terpenoids and Fatty Acid Esters from Underutilized Tiliaceae Shrub Exhibit In Silico Bioactivity and Protein Targets
Computers have made it simpler to anticipate molecular characteristics, toxicity, and pharmacological efficacy in the quest for new drugs. Herbal...
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Identification and Optimization of Protein Tyrosine Phosphatase Inhibitors Via Fragment Ligation
Phosphotyrosine biomimetics are starting points for potent inhibitors of protein tyrosine phosphatases (PTPs) and, thus, crucial for drug...
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Synthesis, activatory effects, molecular docking and ADME studies as rabbit muscle pyruvate kinase activators of ureido phenyl substituted 1,4-dihydropyridine derivatives
In this study, the activation of pyruvate kinase enzyme in vitro via different urea substituents in the para position as functional groups of...
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In silico studies and development of a protein-based electrochemical sensor for selective and sensitive detection of aflatoxin B1
Proteins from different species have been docked with aflatoxin B1 (AFB1) and identified 3 proteins (prostaglandin-E(2)9-reductase from Oryctolagus...
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An electrochemical biosensor for T4 polynucleotide kinase activity identification according to host–guest recognition among phosphate pillar[5]arene@palladium nanoparticles@reduced graphene oxide nanocomposite and toluidine blue
T4 polynucleotide kinase (T4 PNK) helps with DNA recombination and repair. In this work, a phosphate pillar[5]arene@palladium nanoparticles@reduced...
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Binding patterns of derivatives of fisetin and chrysin to the enzyme complex cyclin-dependent kinase 6/cyclin D
Clinical inhibitors of cell-cycle regulatory enzyme cyclin-dependent kinase 6 (CDK6) are not free of harmful consequences to human bodies. Flavonoids...
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AI-based prediction of protein–ligand binding affinity and discovery of potential natural product inhibitors against ERK2
Determination of protein–ligand binding affinity (PLA) is a key technological tool in hit discovery and lead optimization, which is critical to the...
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Investigation of structure–activity relationship: In silico studies of [1, 2, 4]triazolo[4, 3-a]pyridine ureas as P38 kinase inhibitors
P38 kinases are the members of serine/threonine kinases family and play a vital role in the progression of inflammation. In the past two decades,...
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A novel protein extracted from Hemerocallis citrina Borani inhibits hepatocellular carcinoma cell proliferation by regulating mitochondria-dependent apoptosis and aerobic glycolysis
Hemerocallis citrina Borani is a commonly consumed food in Asia and possesses many biologically active ingredients. In this study, a protein named Heme...
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Identification of HPr kinase/phosphorylase inhibitors: novel antimicrobials against resistant Enterococcus faecalis
Enterococcus faecalis , a gram-positive bacterium, is among the most common nosocomial pathogens due to its limited susceptibility to antibiotics and...
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The phosphatase/kinase balance affects phytochrome A and its native pools, phyA′ and phyA″, in etiolated maize roots: evidence from the induction of phyA′ destruction by a protein phosphatase inhibitor sodium fluoride
Phytochrome A (phyA) comprises two native types, phyA′ and phyA″, with distinct spectroscopic, photochemical, and functional properties, differing at...
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Identification of Protein-Coding Gene Structure and Protein-Related Genes and Their Splicing Sites in Kidney Stone Disease: A Protein Big Data Analysis
The study of protein-coding gene structure and protein-related genes in kidney stone disease is used for accurate identification of splicing sites...
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Immunomodulatory activity of semen Ziziphi Spinosae protein: a potential plant protein functional food raw material
Semen Ziziphi Spinosae protein (SZSP) is a new plant protein resource with good food functional properties and health care function. However, the...
