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Production and Evaluation of Nucleoside-Modified mRNA Vaccines for Infectious Diseases
Lipid nanoparticle (LNP)-encapsulated nucleoside-modified mRNA vaccines have demonstrated potency in multiple preclinical models against various...
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Drug Resistance in Antiviral Therapy
Drug resistance in antiviral therapy is a major public health challenge. This resistance can occur among immunocompromised patients where persistent...
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Identifying Transmembrane Interactions in Receptor Protein Tyrosine Phosphatase Homodimerization and Heterodimerization
Receptor protein tyrosine phosphatases (RPTPs) are one of the key regulators of receptor tyrosine kinases (RTKs) and therefore play a critical role...
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Using RVFV as a Vector Platform for the Expression of Ruminant Disease Antigens
Live attenuated viruses remain as vaccine agents with unparalleled performance in terms of duration, magnitude, and breadth of induced immune...
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Porous gold nanoparticles for attenuating infectivity of influenza A virus
BackgroundInfluenza viruses (IVs) have become increasingly resistant to antiviral drugs that target neuraminidase and matrix protein 2 due to gene...
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Herbaspirillum seropedicae strain HRC54 expression profile in response to sugarcane apoplastic fluid
Bacterial transcriptome profiling in the presence of plant fluids or extracts during microbial growth may provide relevant information on...
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POCT Detection of 14 Respiratory Viruses Using Multiplex RT-PCR
Over the past 6 years, acute respiratory infections have constituted an average of more than 70,000 cases in South Korea. It results in a high...
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Structures of the ADGRG2–Gs complex in apo and ligand-bound forms
Adhesion G protein-coupled receptors are elusive in terms of their structural information and ligands. Here, we solved the cryogenic-electron...
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Bioactive Compounds of Jack Beans (Canavalia Species)
Underutilized and less known legumes possess immense nutritional and bioactive attributes based on the traditional knowledge of tribals or local...
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Virus-like Particles as Antiviral Vaccine: Mechanism, Design, and Application
Virus-like particles (VLPs) are viral structural protein that are noninfectious as they do not contain viral genetic materials. They are safe and...
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Detection of Protein Tyrosine Phosphatase Interacting Partners by Mass Spectrometry
Unraveling interacting partners of protein tyrosine (Tyr) phosphatases is considered a key aspect in resolving the regulation of signaling cascades...
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Anti-nutritional Attributes of Faba-Bean
Faba bean (Viciafaba L.) is belongs to Fabaceae family, which is also known as horse bean or broad bean. They are one of the oldest cultivated crops...
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Stimuli-Responsive DNA Nanostructures for Biomedical Applications
Besides being a carrier of genetic information, nucleic acid as a category of biomacromolecules can function well as the building block for the...
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Streamlining N-terminally anchored yeast surface display via structural insights into S. cerevisiae Pir proteins
Surface display co-opts yeast’s innate ability to embellish its cell wall with mannoproteins, thus converting the yeast’s outer surface into a...
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Nanobody-based pannexin1 channel inhibitors reduce inflammation in acute liver injury
BackgroundThe opening of pannexin1 channels is considered as a key event in inflammation. Pannexin1 channel-mediated release of adenosine...
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Characterization of a broadly cross reactive tetravalent human monoclonal antibody, recognizing conformational epitopes in receptor binding domain of SARS-CoV-2
We used human semi-synthetic phage antibody gene libraries to select anti-SARS-CoV-2 RBD scFv antibody fragment and subsequent characterization of...
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Nano-adjuvants as Effective Next-Generation Antimicrobial Agents
Adaptive immunity is a feature peculiar to vertebrates which is responsible for defence against invading pathogens. It is a system that recognizes...
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Synthesis approach-dependent antiviral properties of silver nanoparticles and nanocomposites
Numerous viral infections are common among humans, and some can lead to death. Even though conventional antiviral agents are beneficial in...
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Antiviral Potential of Curcumins: Ethnopharmacology, Chemistry, and Clinical Studies Focusing on Mechanism of Action and Future Perspectives
Viruses have always been a serious public health concern, and scientists have worked diligently to make new antiviral medicines. Virus infections...
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Physicochemical tools for studying virus interactions with targeted cell membranes in a molecular and spatiotemporally resolved context
The objective of this critical review is to provide an overview of how emerging bioanalytical techniques are expanding our understanding of the...
