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Liposomes for effective drug delivery to the ocular posterior chamber
BackgroundAge-related macular degeneration (AMD) is a leading cause of severe visual deficits and blindness. Meanwhile, there is convincing evidence...
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Wearing the Lab: Advances and Challenges in Skin-Interfaced Systems for Continuous Biochemical Sensing
Continuous, on-demand, and, most importantly, contextual data regarding individual biomarker concentrations exemplify the holy grail for personalized...
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Intranasal Drug Delivery to the Brain
The barriers that separate the blood from brain interstitial and cerebrospinal fluids present a significant challenge to efficient and practical drug...
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Stacking and Detecting Blood Glutathione as a Cation under Strong Acidic Conditions by Capillary Electrophoresis using Acetonitrile-salt Stacking Method
AbstractBlood glutathione (exists in both reduced and oxidized states) was firstly stacked and separated as a cation using acetonitrile–salt stacking...
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Biochemical characterization of a glycosyltransferase Gtf3 from Mycobacterium smegmatis: a case study of improved protein solubilization
Glycosyltransferases (GTs) are widely present in several organisms. These enzymes specifically transfer sugar moieties to a range of substrates. The...
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Recent (2018–2020) development in capillary electrophoresis
Development of new capillary electrophoresis (CE) methodology and instrumentation, as well as application of CE to solve new problems, remains an...
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Development of triptolide-nanoemulsion gels for percutaneous administration: physicochemical, transport, pharmacokinetic and pharmacodynamic characteristics
BackgroundThis work aimed to provide useful information on the use of nanoemulsions for the percutaneous administration of triptolide. Lipid...
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Fiber-shaped organic electrochemical transistors for biochemical detections with high sensitivity and stability
Precise and continuous monitoring of biochemicals by biosensors assists to understand physiological functions for various diagnostics and therapeutic...
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Thermographic examination of prick test reactions with local anesthetic
In allergology, skin diagnostic tests are divided into epicutaneous, cutaneous and intracutaneous. The prick test is one of the cutaneous tests used...
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Thermometric analysis of blood metabolites in ICU patients
Real-time monitoring of patient’s blood metabolites, such as glucose and lactate, could potentially improve surgery and recovery outcomes for...
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Micro- and nano-devices for electrochemical sensing
Electrode miniaturization has profoundly revolutionized the field of electrochemical sensing, opening up unprecedented opportunities for probing...
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Determination of Melatonin Hormone and Neurotransmitters in Cerebrospinal Fluid: Method Validation and Uncertainty Calculations
The uncertainty of measurement for well-known neurotransmitters like serotonin, noradrenalin and gamma-aminobutyric acid (GABA), glutamate and...
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Microfluidics-Mass Spectrometry Combination Systems for Single-Cell Analysis
Due to the existence of heterogeneities in individual cells, analysis of intercellular contents at the single-cell level has become an important...
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Recent Advances of Metal-Organic Frameworks-based Nanozymes for Bio-applications
Artificial nanoenzymes with enzyme-like catalytic activity have gradually become an alternative to natural enzymes due to their low production cost,...
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Host-Guest Sensing by Nanopores and Nanochannels
Nanopore sensing can detect biological analytes at the single-molecule level, by monitoring the ionic current modulations induced by the passage of...
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Progress on the reaction-based methods for detection of endogenous hydrogen sulfide
Hydrogen sulfide (H 2 S) is a biologically signaling molecule that mediates a wide range of physiological functions, which is frequently misregulated...
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Use of mTRAQ derivatization reagents on tissues for imaging neurotransmitters by MALDI imaging mass spectrometry: the triple spray method
During drug development, matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry is used for visually elucidating the...
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Hyperoside: A Review of Resources, Synthesis Pathways, Physicochemical Properties, Metabolism, Pharmacological Activities, Clinical Trials and Human Studies, Toxicology and Safety, Marketed Products, and Patents
Hyperoside is a natural flavonol glycoside that widely exists in many tissues (especially the aerial parts) of diverse plants. Remarkably, hyperoside...
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Copper Ion Uptake by Chitosan in the Presence of Amyloid-β and Histidine
Alzheimer’s disease (AD) is related to the anomalous binding that occurs between amyloid-β peptide (Aβ) and copper ion, through imidazole ring of...
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Study on the interaction between active components from traditional Chinese medicine and plasma proteins
Traditional Chinese medicine (TCM), as a unique form of natural medicine, has been used in Chinese traditional therapeutic systems over two thousand...