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In vitro and In vivo Biocompatibility Evaluation of Freeze Dried Gelatin Haemostat
Gelatin sponges developed by crosslinking gelatin with formaldehyde followed by controlled freeze-drying results in soft, spongy porous structures,...
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Optimization of Expression and Purification of Schistosoma mansoni Antigens in Fusion with Rhizavidin
Schistosomiasis causes significant morbidity and mortality. Vaccine efforts to date indicate the need to increase the immunogenicity of Schistosoma...
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Overcoming multidrug-resistant lung cancer by mitochondrial-associated ATP inhibition using nanodrugs
Despite the development of therapeutic modalities to treat cancer, multidrug resistance (MDR) and incomplete destruction of deeply embedded lung...
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Heterologous expression of nattokinase from B. subtilis natto using Pichia pastoris GS115 and assessment of its thrombolytic activity
BackgroundNattokinase is a fibrinolytic enzyme that has huge market value as a nutritional supplement for health promotion. In order to increase...
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In Vitro Comparison Study of Plasma Treated Bilayer PGS/PCL and PGS/PLA Scaffolds for Vascular Tissue Engineering
Biomaterial selection is one of the important factors in tissue engineering vascular graft (TEVG) because of its hemocompatibility, mechanical...
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Probing the microbial diversity and probiotic candidates from Pakistani foods: isolation, characterization, and functional profiling
Probiotics represent beneficial living microorganisms that confer physiological, nutritional, and functional advantages to human health, holding...
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Polypyrrole-palladium nanocomposite as a high-efficiency transducer for thrombin detection with liposomes as a label
Sensitive and selective determination of protein biomarkers with high accuracy often remains a great challenge due to their existence in the human...
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Neutrophil membrane engineered HucMSC sEVs alleviate cisplatin-induced AKI by enhancing cellular uptake and targeting
Human umbilical cord mesenchymal stem cells-derived small extracellular vesicles (hucMSC-sEVs) have been demonstrated as a therapeutic agent to...
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Biomedical Application of Porous Carbon and Its Future in Precision Medical Devices
Porous carbon is a versatile material. They have been used for ages and have significant industrial applications in adsorption and catalysis. The...
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Hypochlorite-Induced Disturbance in the Secondary Structure of the Coagulation Factor XIII
AbstractCoagulation factor XIII (FXII), which is converted into the active form of FXIIIa under the combined action of thrombin and calcium ions,...
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Endophytic fungi: a potential source of industrial enzyme producers
Microbial enzymes have gained interest for their widespread use in various industries and medicine due to their stability, ease of production, and...
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Purification of Soluble Membrane-Bound Ambystoma mexicanum Epidermal Lipoxygenase from E. coli and Its Growth Effect on Human Fetal Foreskin Fibroblast
Lipoxygenases are non-heme iron-containing lipid dioxygenases enzymes that catalyze the hydroperoxidation of lipids. The Mexican axolotl ( Ambystoma...
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Computational modeling of culture media for enhanced production of fibrinolytic enzyme from marine bacterium Fictibacillus sp. strain SKA27 and in vitro evaluation of fibrinolytic activity
The present study reports the optimized production and purification of an extremely active fibrinolytic enzyme from newly isolated marine bacterium Fictibacillus...
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MYPT1 O-GlcNAc modification regulates sphingosine-1-phosphate mediated contraction
Many intracellular proteins are modified by N -acetylglucosamine, a post-translational modification termed O -GlcNAc. This modification is found on...
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Molecular Characterization of Bacterial Fibrinolytic Proteins from Indonesian Traditional Fermented Foods
Previously, the crude extracts of recombinant Nattokinase (NK) variants i.e. NatTK and NatOC and one wild type Douchi Fibrinolytic Enzyme (DFE) from...
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A novel delivery nanobiotechnology: engineered miR-181b exosomes improved osteointegration by regulating macrophage polarization
BackgroundMany patients suffer from implant loosening after the implantation of titanium alloy caused by immune response to the foreign bodies and...
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Deep dive on the proteome of salivary extracellular vesicles: comparison between ultracentrifugation and polymer-based precipitation isolation
Salivary extracellular vesicles (EVs), as novel functional carriers and potential biomarkers, are usually obtained by ultracentrifugation (UC) and...
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Characterization of Platelet-Rich Plasma/Gellan Gum Hydrogel Composite for Biological Performance to Induce Chondrogenesis from Adipose-Derived Stem Cells
In this experiment, hydrogel composite was developed with gellan gum (GG) and platelet-rich plasma (PRP) to induce chondrogenesis of adipose-derived...
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Biomimetic phosphorylcholine-modified bacterial cellulose membranes with cell fouling resistance
AbstractNovel biomimetic zwitterionic phosphorylcholine (PC) modified bacterial cellulose (PCBC) membranes were prepared based on the Pudovik...
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Circulating miR-135 May Serve as a Novel Co-biomarker of HbA1c in Type 2 Diabetes
Hemoglobin A1c (HbA1c) is a reliable marker of insulin resistance in normal glucose tolerance patients; however, several physiological,...
