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Spatial Screening for the Identification of the Bioactive Conformation of Integrin Ligands
The development of low-molecular-weight, non-peptidic, and orally available drugs starting from a biologically active peptide is one of the great...
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Development of small molecules designed to modulate protein–protein interactions
Protein–protein interactions are ubiquitous, essential to almost all known biological processes, and offer attractive opportunities for therapeutic...
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Dietary Calcium and Obesity
The incidence of obesity in the United States is reaching epidemic proportions, and it is estimated that 97 million adults are overweight or obese...
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PASSCLAIM1—Body weight regulation, insulin sensitivity and diabetes risk
Background:Insulin sensitivity is a key function in human metabolism because it has a crucial role in the development of disease that are...
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Fundamentals of Receptor-Based Diagnostic Metalloradiopharmaceuticals
In the last decade, a large number of radiolabeled small biomolecules have been studied for their potential as radiopharmaceuticals for diagnosis and...
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Exploring privileged structures: the combinatorial synthesis of cyclic peptides
Head-to-tail cyclic peptides have been reported to bind to multiple, unrelated classes of receptor with high affinity. They may therefore be...
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Mutation of Lysine Residues of the 78-kDa Gastrin-Binding Protein Reduces Gastrin Binding
The 78-kDa gastrin-binding protein (GBP) is a likely target for the antiproliferative effects of gastrin/cholecystokinin receptor antagonists on...
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A Short and Efficient Synthesis of Novel N-(2,3-dihydro-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)-2-carboxamides
Several novel N-(2,3-dihydro-2-oxo-5-phenyl-1 H -1,4-benzodiazepin-3-yl)-2-carboxamides were prepared by acyl coupling of 2-aminobenzophenones with...
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Obesity: molecular bases of a multifactorial problem
Obesity could well become the most common health problem of the 21 st century. There are more opportunities to consume large quantities of food: big...
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Cyclopropane Derivatives and their Diverse Biological Activities
Natural and synthetic cyclopropanes bearing simple functionalities are endowed with a large spectrum of biological properties ranging from enzyme...
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Photoaffinity Labeling in Biological Signal Transduction
Biological signal transduction pathways control the essential functions in all cells and tissues. Understanding the mechanisms at the molecular level...
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Application of Biosensors to the Measurement of Neurotransmitter function
The 1990s is the “decade of the brain” and it has seen considerable advances in the methodology available for investigating brain function in...
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Comprehensive survey of chemical libraries yielding enzyme inhibitors, receptor agonists and antagonists, and other biologically active agents: 1992 through 1997
This review is a historical accounting of chemical libraries from which biologically active agents have been obtained. The comprehensive tabulation...
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Synthesis and Applications of Conformationally Constrained Phenylalanine Analogues
The use of conformationally constrained amino acids to probe how bioactive molecules bind to their receptors is a commonly used approach to the...
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Microbial synthesis of chiral intermediates for β-3-receptor agonists
Chiral intermediates were prepared by biocatalytic processes for the chemical synthesis of β-3-receptor agonists. These include: (i) the microbial...
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Pharmacologic Therapy of Obesity
This chapter provides physicians with guide to current and potential drugs used for the treatment of obesity, excluding agents being developed based...
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Biochemistry of Platelet Activation
Platelets circulate in the blood stream as anucleate discoid cells, at a number of 150,000–350,000 per μl and have a life span of 10 days in man....
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