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Mining the cellular inventory of pyridoxal phosphate-dependent enzymes with functionalized cofactor mimics
Pyridoxal phosphate (PLP) is an enzyme cofactor required for the chemical transformation of biological amines in many central cellular processes....
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Enzymatic Modification of Polymers
In polymer applications and development, it is often necessary to modify an existing polymer structure in order to impart special end-use properties....
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Enhancing surfactin production by using systematic CRISPRi repression to screen amino acid biosynthesis genes in Bacillus subtilis
BackgroundSurfactin is a cyclic lipopeptide that is of great industrial use owing to its extraordinary surfactant power and antimicrobial, antiviral,...
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Impact of Target-Based Drug Design in Anti-bacterial Drug Discovery for the Treatment of Tuberculosis
TuberculosisTuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis...
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Examination of the performance of semiempirical methods in QM/MM studies of the SN2-like reaction of an adenylyl group transfer catalysed by ANT4′
Quantum mechanical (QM) semiempirical methods (SMs), combined with molecular mechanics (MM) force fields, are extensively used in theoretical studies...
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Biorefining of protein waste for production of sustainable fuels and chemicals
To mitigate the climate change caused by CO 2 emission, the global incentive to the low-carbon alternatives as replacement of fossil fuel-derived...
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Carbon-Phosphorus Lyase—the State of the Art
Organophosphonates are molecules that contain a very chemically stable carbon-phosphorus (C-P) bond. Microorganisms can utilize phosphonates as...
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Aspartic and glutamic acids polymers: preparation and applications in medicinal chemistry and pharmaceutics
The methods of the fabrication of polymers based on aspartic and glutamic acids as monomers are reviewed. The methods are perspective from the...
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Efficient L-Alanine Production by a Thermo-Regulated Switch in Escherichia coli
L-Alanine has important applications in food, pharmaceutical and veterinary and is used as a substrate for production of engineered thermoplastics....
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Secretory production of a beta-mannanase and a chitosanase using a Lactobacillus plantarum expression system
BackgroundHeterologous production of hydrolytic enzymes is important for green and white biotechnology since these enzymes serve as efficient...
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Biocatalytic Applications
Of all the types of enzyme-catalyzed reactions, hydrolytic transformations involving amide and ester bonds are the easiest to perform using...
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Bioactive Organoselenium Compounds and Therapeutic Perspectives
After 1984, when ebselen was tested as a mimetic of the key antioxidant enzyme glutathione peroxidase (GPx), a plethora of organoselenium compounds...
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In vivo plug-and-play: a modular multi-enzyme single-cell catalyst for the asymmetric amination of ketoacids and ketones
BackgroundTransaminases have become a key tool in biocatalysis to introduce the amine functionality into a range of molecules like prochiral...
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Special Techniques
Most biocatalysts can be used in a straightforward manner by regarding them as chiral catalysts and by applying standard methodology, i.e., in...
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Production of Cyclosporine A by Submerged Fermentation
Cyclosporin A is a cyclic undecapeptide with a variety of biological activities including immunosuppressive, anti-inflammatory, antifungal, and...
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A simplified LC−MS/MS method for rapid determination of cycloserine in small-volume human plasma using protein precipitation coupled with dilution techniques to overcome matrix effects and its application to a pharmacokinetic study
Matrix effects have been a major concern when develo** LC−MS/MS methods for quantitative bioanalysis of cycloserine. Sample handling procedures...
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Biochemical and Mutational Characterization of N-Succinyl-Amino Acid Racemase from Geobacillus stearothermophilus CECT49
N -Succinyl-amino acid racemase (NSAAR), long referred to as N -acyl- or N -acetyl-amino acid racemase, is an enolase superfamily member whose...
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Metabolic processes of Methanococcus maripaludis and potential applications
Methanococcus maripaludis is a rapidly growing, fully sequenced, genetically tractable model organism among hydrogenotrophic methanogens. It has the...
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In Silico Identification for α-Amino-ε-Caprolactam Racemases by Using Information on the Structure and Function Relationship
In silico identification for enzymes having desired functions is attractive because there is a possibility that numerous desirable enzymes have been...
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Recent advancements in bioreactions of cellular and cell-free systems: A study of bacterial cellulose as a model
Conventional approaches of regulating natural biochemical and biological processes are greatly hampered by the complexity of natural systems....