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Systematic identification of endogenous strong constitutive promoters from the diazotrophic rhizosphere bacterium Pseudomonas stutzeri DSM4166 to improve its nitrogenase activity
BackgroundBiological nitrogen fixation converting atmospheric dinitrogen to ammonia is an important way to provide nitrogen for plants. Pseudomonas...
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The Study of mRNA Expression Profiles of Main Cell Function Regulator Genes in Unchanged Colon Mucosa from Healthy Donors
AbstractA comparative analysis of molecular genetic phenotypes of mucous membrane cells has been carried out in five anatomical regions of the large...
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Site-directed mutagenesis of the quorum-sensing transcriptional regulator SinR affects the biosynthesis of menaquinone in Bacillus subtilis
BackgroundMenaquinone (MK-7) is a highly valuable vitamin K 2 produced by Bacillus subtilis . Common static metabolic engineering approaches for...
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In silico identification of potential inhibitor for TP53-induced glycolysis and apoptosis regulator in head and neck squamous cell carcinoma
Head and neck squamous cell carcinoma (HNSCC) is the six most common cancer globally and most common cancer in men in India. The metabolic regulation...
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Multi-regulator of EZH2-PPARs Therapeutic Targets: A Hallmark for Prospective Restoration of Pancreatic Insulin Production and Cancer Dysregulation
The unexpected rise in cancer and diabetes statistics has been a significant global threat, inciting ongoing research into various biomarkers that...
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MsrR is a thiol-based oxidation-sensing regulator of the XRE family that modulates C. glutamicum oxidative stress resistance
BackgroundCorynebacterium glutamicum thrives under oxidative stress caused by the inevitably extreme environment during fermentation as it harbors...
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Resveratrol ameliorates myocardial ischemia/reperfusion induced necroptosis through inhibition of the Hippo pathway
Myocardial ischemia-reperfusion (I/R) injury is a major cause of poor hemodynamic reconstitution outcomes after myocardial infarction or circulatory...
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Two-Component Regulatory Systems in Microbial Pathogenesis
Bacteria would adapt to ever-changing multifaceted environments. Two-component systems (TCSs) are predominantly used by bacteria to respond to...
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Exploring the multi-level regulation of lignocellulases in the filamentous fungus Trichoderma guizhouense NJAU4742 from an omics perspective
BackgroundFilamentous fungi are highly efficient at deconstructing plant biomass by secreting a variety of enzymes, but the complex enzymatic...
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Optimizing enzyme properties to enhance dihydroxyacetone production via methylglyoxal biosensor development
BackgroundDihydroxyacetone (DHA) stands as a crucial chemical material extensively utilized in the cosmetics industry. DHA production through the...
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Low dissolved oxygen supply functions as a global regulator of the growth and metabolism of Aurantiochytrium sp. PKU#Mn16 in the early stages of docosahexaenoic acid fermentation
BackgroundThraustochytrids accumulate lipids with a high content of docosahexaenoic acid (DHA). Although their growth and DHA content are...
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Plant In Vitro Culture Factories for Pentacyclic Triterpenoid Production
Pentacyclic triterpenoids are a diverse subclass of naturally occurring terpenes with various biological activities and applications. These compounds...
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Constructing a novel expression system by specific activation of amylase expression pathway in Penicillium
BackgroundFilamentous fungi have long been used as hosts for the production of proteins, enzymes and valuable products in various biotechnological...
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EHMT2 Suppresses ARRB1 Transcription and Activates the Hedgehog Signaling to Promote Malignant Phenotype and Stem Cell Property in Oral Squamous Cell Carcinoma
Oral squamous cell carcinoma (OSCC) represents the primary subtype of head and neck squamous cell carcinoma (HNSCC), characterized by a high...
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Engineering prokaryotic regulator IrrE to enhance stress tolerance in budding yeast
BackgroundStress tolerance is one of the important desired microbial traits for industrial bioprocesses, and global regulatory protein engineering is...
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Insight into Carrot Carotenoids in Post-genomic World for Higher Nutrition
Carrot is one of the major root crops having nutritional and economic value belonging to eudicot plant family Apiaceae. Carrot root is the reservoir...
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Exploring novel herbicidin analogues by transcriptional regulator overexpression and MS/MS molecular networking
BackgroundHerbicidin F has an undecose tricyclic furano-pyrano-pyran structure with post-decorations. It was detected from Streptomyces mobaraensis ...
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Autophagic Regulation of Adipogenesis Through TP53INP2: Insights from In Silico and In Vitro Analysis
Obesity is an epidemic disease associated with multimorbidity resulting in higher mortality risk. The imbalance between energy storage and...
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Suppression of JAK2/STAT3 Pathway by Notoginsenoside R1 Reduces Epithelial-Mesenchymal Transition in Non-small Cell Lung Cancer
It has bene reported that a novel saponin-notoginsenoside R1 (NGR1) possesses strong anti-tumor activities. This study aimed to investigate the role...
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Regulation of Penicillin Biosynthesis in Filamentous Fungi
The β-lactam antibiotic penicillin is one of the mainly used antibiotics for the therapy of infectious diseases. It is produced as end product by...