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Cell membrane-based nanomaterials for theranostics of central nervous system diseases
Central nervous system (CNS) diseases have been widely acknowledged as one of the major healthy concerns globally, which lead to serious impacts on...
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Treg cell-derived exosomes miR-709 attenuates microglia pyroptosis and promotes motor function recovery after spinal cord injury
Neuroinflammation is an important cause of poor prognosis in patients with spinal cord injury. pyroptosis is a new type of inflammatory cell death....
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Nrf2 activator Diethyl Maleate attenuates ROS mediated NLRP3 inflammasome activation in murine microglia
Microglia are the tissue-resident immune cells of the central nervous system. As a part of the innate immune response, NLR Family Pyrin Domain...
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Deciphering the neuroprotective effect of ascorbic acid mediated synthesis of iron oxide nanoparticles against Parkinson’s disease: an in vitro and in vivo approach
One of the most prevalent neurological movement diseases affecting the geriatric population globally is Parkinson’s disease (PD). Recent studies have...
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Insights from molecular docking and molecular dynamics on the potential of vitexin as an antagonist candidate against lipopolysaccharide (LPS) for microglial activation in neuroinflammation
BackgroundNeuroinflammation has been identified to be the key player in most neurodegenerative diseases. If neuroinflammation is left to be...
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Physalis alkekengi L. var. francheti alleviates neuronal cell death caused by activated microglia in vitro
Microglia are the macrophages that reside in the brain. Activated microglia induces further activation of astrocytes and neuronal cells for mounting...
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A rapid and robust method for amino acid quantification using a simple N-hydroxysuccinimide ester derivatization and liquid chromatography-ion mobility-mass spectrometry
The vast majority of mass spectrometry (MS)-based metabolomics studies employ reversed-phase liquid chromatography (RPLC) to separate analytes prior...
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Human neural stem cell-derived extracellular vesicles protect against Parkinson’s disease pathologies
BackgroundNeural stem cells (NSCs) have the ability to generate a variety of functional neural cell types and have a high potential for neuronal cell...
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Trimethylamine N-oxide: role in cell senescence and age-related diseases
IntroductionHayflick and Moorhead first demonstrated cell senescence as the irreversible growth arrest of cells after prolonged cultivation. Telomere...
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Melanin-like polydopamine nanoparticles mediating anti-inflammatory and rescuing synaptic loss for inflammatory depression therapy
Inflammatory depression is closely related to neuroinflammation. However, current anti-inflammatory drugs have low permeability to cross blood–brain...
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Macrophage cell membrane-based nanoparticles: a new promising biomimetic platform for targeted delivery and treatment
Synthetic nanoparticles with surface bioconjugation are promising platforms for targeted therapy, but their simple biological functionalization is...
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Neuropharmacological Alterations by a Rice Contaminant Stenotrophomonas maltophilia: a Detailed Bio-molecular and Mechanistic Landscape
Contaminated rice is a major source of food poisoning in human communities where our earlier study showed Stenotrophomonas maltophilia , a...
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STIM2 Suppression Blocks Glial Activation to Alleviate Brain Ischemia Reperfusion Injury via Inhibition of Inflammation and Pyroptosis
Cerebral ischemia/reperfusion injury (CIRI) involves various pathogenic mechanisms, including cytotoxicity, apoptosis, inflammation, and pyroptosis....
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Silica NPs–Cytotoxicity Cross-Talk: Physicochemical Principles and Cell Biology Responses
Many advances have been made in the preparation, optimization, and applications of silica nanoparticles (NPs) in biomedical nanotechnology....
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Antistress and Antiaging Potentials of Alpha-Lipoic Acid: Insights from Cell Culture–Based Experiments
Chronic stress has been linked to a large number of pathologies, including cancer, premature aging, and neurodegenerative diseases. The accumulation...
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Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression
BackgroundNeuroinflammation is an important component mechanism in the development of depression. Exosomal transfer of MDD-associated microRNAs...
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Cell-derived extracellular vesicles and membranes for tissue repair
Humans have a limited postinjury regenerative ability. Therefore, cell-derived biomaterials have long been utilized for tissue repair. Cells with...
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Traditional Crude Drugs Against Encephalitis Infection: Ethnopharmacology, Chemistry, and Clinical and Preclinical Studies
Encephalitis infection is an infection in the brain causing inflammation of the brain. An infection or an autoimmune response generally causes...
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Intraocular delivery of ZIF-90-RhB-GW2580 nanoparticles prevents the progression of photoreceptor degeneration
Photoreceptor degeneration is one of the major causes of progressive blindness which lacks of curative treatment. GW2580, a highly selective...
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Bioengineered stem cell membrane functionalized nanoparticles combine anti-inflammatory and antimicrobial properties for sepsis treatment
BackgroundSepsis is a syndrome of physiological, pathological and biochemical abnormalities caused by infection. Although the mortality rate is lower...
