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Young Sca-1+ bone marrow stem cell-derived exosomes preserve visual function via the miR-150-5p/MEKK3/JNK/c-Jun pathway to reduce M1 microglial polarization
BackgroundPolarization of microglia, the resident retinal immune cells, plays important roles in mediating both injury and repair responses...
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ω-3PUFAs Inhibit Hypoxia-Induced Retinal Neovascularization via Regulating Microglial Pyroptosis through METTL14-Mediated m6A Modification of IFNB1 mRNA
Retinal neovascular disease is the leading reason of vision impairment in all ages. Here, we figured out the function and mechanism of omega-3...
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Mechanism of Resveratrol Improving Ischemia–Reperfusion Injury by Regulating Microglial Function Through microRNA-450b-5p/KEAP1/Nrf2 Pathway
Alterations in the M1/M2 polarization phenotype significantly affect disease progression. Antioxidant and anti-inflammatory protective effects of...
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Effect of resveratrol and combination of resveratrol and donepezil on the expression of microglial cells and astrocytes in Wistar albino rats of colchicine-induced Alzheimer’s disease
AimThe goal was to evaluate the effect of resveratrol (RS) and combination therapy of RS and donepezil (DPZ), on the numerical expression of...
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Microfluidics-enabled mesenchymal stem cell derived Neuron like cell membrane coated nanoparticles inhibit inflammation and apoptosis for Parkinson’s Disease
Parkinson’s disease (PD) is the second largest group of neurodegenerative diseases, and its existing drug treatments are not satisfactory. Natural...
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Changes in mitochondrial morphology modulate LPS-induced loss of calcium homeostasis in BV-2 microglial cells
Microglial activation involves both fragmentation of the mitochondrial network and changes in cellular Ca 2+ homeostasis, but possible modifications...
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Dibenzoylmethane ameliorates adiposity-mediated neuroinflammatory response and inflammation-mediated neuronal cell death in mouse microglia and neuronal cells
Dibenzoylmethane (DBM), a licorice-derived component, has numerous health benefits. The current study aimed to investigate the effect of DBM on...
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α-Linolenic Acid Induces Microglial Activation and Extracellular Tau Internalization
Neuroinflammation is the brain condition that occurs due to the hyper-activation of brain’s immune cells and microglia, over the stimulation of...
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Anti-inflammatory components isolated from Atractylodes macrocephala in LPS-induced RAW264.7 macrophages and BV2 microglial cells
The phytochemical investigation on the methanol extract of the rhizomes of Atractylodes macrocephala resulted in the discovery of one new compound...
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Wild radish (Raphanus sativus var. hortensis f. raphanistroides) root extract protects neuronal cells by inhibiting microglial activation
External stimulus-induced activation of microglia plays an important role in the protection of neurons in the central nervous system; however,...
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Zerumbone attenuates lipopolysaccharide-induced activation of BV-2 microglial cells via NF-κB signaling
The brain is considered an immune-privileged organ. However, it has been found that inflammation mediated by microglia, which were once believed to...
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The secretome of microglia induced by IL-4 of IFN-γ differently regulate proliferation, differentiation and survival of adult neural stem/progenitor cell by targeting the PI3K-Akt pathway
Microglia has been reported to be able to regulate the proliferation, differentiation and survival of adult neural stem/progenitor cells (NSPCs) by...
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Measuring Antibody-Mediated Tau Fibril Uptake in Microglia by Flow Cytometry
Microglia are brain-resident phagocytic cells, considered to be the innate immune cells of the central nervous system. Microglia respond to both...
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Interaction of Tau with G-Protein-Coupled Purinergic P2Y12 Receptor by Molecular Docking and Molecular Dynamic Simulation
Alzheimer’s disease, a progressive neurological disorder, is characterized by the accumulation of neurofibrillary tangles and senile plaques by Tau...
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Purinergic Receptor P2Y12-Mediated Tau Internalization in Microglia
Microglia are the resident brain macrophage cells that are involved in constant surveillance of brain microenvironment. In Alzheimer’s disease,...
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Therapeutic Effects of Geranium Oil in MPTP-Induced Parkinsonian Mouse Model
Parkinson’s disease (PD) is an incurable neurodegenerative disease characterized by motor and non-motor disabilities resulting from neuronal cell...
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Cell-Derived Extracellular Vesicles for Immune Modulation: Preclinical and Clinical Perspectives
Small extracellular vesicles from many cell types have demonstrated potential promise as therapeutic strategies to modulate immune and inflammatory...
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Non-stem cell-derived exosomes: a novel therapeutics for neurotrauma
Neurotrauma, encompassing traumatic brain injuries (TBI) and spinal cord injuries (SCI) impacts a significant portion of the global population. While...
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SHED-derived exosomes attenuate trigeminal neuralgia after CCI of the infraorbital nerve in mice via the miR-24-3p/IL-1R1/p-p38 MAPK pathway
BackgroundMicroglial activation in the spinal trigeminal nucleus (STN) plays a crucial role in the development of trigeminal neuralgia (TN). The...
