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Proton-Coupled Electron Transfer Reactions at a Distance in DNA Duplexes
The nucleic acid analog 2-aminopurine (2AP) can be site-specifically incorporated into oligonucleotides without significantly affecting the thermal...
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Pheromones of True Bugs
The Heteroptera, or true bugs, comprise a large and widely distributed group of sucking insects, with about 38,000 described species, some of which...
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Pheromone Reception
Insects are analytical chemists par excellence. They perceive the world through semiochemicals with inordinate sensitivity. A male moth, for example,...
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Cyclodextrin-Based Supramolecular Polymers
Supramolecular polymers were prepared by inclusion of a guest in cyclodextrin via a covalent bond. The structures of the supramolecular oligomers and...
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Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications
Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
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Lentiviral Vectors
We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
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Plasmid Vaccines and Therapeutics: From Design to Applications
In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...
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Hemicellulose
Hemicelluloses, comprising the non-cellulose cell-wall polysaccharides of vegetative and storage tissues of annual and perennial plants, represent...
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Analysis of Polysaccharides by Ultracentrifugation. Size, Conformation and Interactions in Solution
The launch of the XL-I analytical ultracentrifuge by Beckman Instruments (Palo Alto, USA) in 1996 and subsequent development of penetrating...
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Large-Scale Production of Hairy Root
Many products of interest are synthesized in organized tissues, but not formed in suspension or callus culture. Therefore, most attention has been...
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Extracellular Communication in Bacteria
Populations of bacterial cells often coordinate their responses to changes in their local environmental conditions through “quorum sensing”, a...
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Functional, Discrete, Nanoscale Supramolecular Assemblies
The last decade has witnessed an unprecedented pursuit of discrete, nanoscale supramolecular aggregates, built by modern methods of self-assembly...
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Reactivity of Phosphorus Centered Radicals
The recent literature devoted to the chemical reactivity of the main families of phosphorus centered radicals is surveyed. Various tin-free radical...
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Ribosomal RNA Recognition by Aminoglycoside Antibiotics
2-Deoxystreptamine (2-DOS) aminoglycosides are a family of structurally related broad-spectrum antibiotics that are used widely in the clinic. Their...
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Anion Sensing by Metal-Based Receptors
Metal-based receptors are an important and expanding class of molecules in anion sensing. This review describes the subject with specific focus on...
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Radiolabeled Integrin αvβ3 Antagonists as Radiopharmaceuticals for Tumor Radiotherapy
Integrins are a family of proteins that facilitate cellular adhesion to and migration on the extracellular matrix proteins found in intercellular...
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Abiotic Guanidinium Receptors for Anion Molecular Recognition and Sensing
The guanidinium functionality has been utilized by molecular recognition chemists as a strong and selective binder for anionic guests. Guanidiniums,...
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Engineering Fluorescent Proteins
Green fluorescent protein from the jellyfish Aequorea victora (GFP) and GFP-like proteins from Anthozoa species encode light-absorbing chromophores...
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Live Cell Spinning Disk Microscopy
In vivo microscopy of dynamic processes in cells and organisms requires very fast and sensitive acquisition methods. Confocal laser scanning...
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New Trends in Ylide Chemistry
This review concerns in the first part the works published during the last three years on the synthesis and reactivity of stabilized ylides...