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“Zwitterionic Phospholide Derivatives—New Ambiphilic Ligands”
Attachment of one or two phosphonio substituents converts a phospholide anion not only into a zwitterion or cation but induces as well a...
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Inclusion Bodies: Formation and Utilisation
The efficient in vivo folding of many heterologous proteins is a major bottleneck of high level production in bacterial hosts and simple optimisation...
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Monitoring of Stress Responses
New developments in the RNA analysis techniques now enable a comprehensive view on the bacterial physiology under bioprocess conditions. The DNA-chip...
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Functional Magnetic Particles for Medical Application
Magnetic particles for medical applications have been developed by many researchers. Since magnetic particles have unique magnetic features not...
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Analysis and Control of Proteolysis of Recombinant Proteins in Escherichia coli
Proteolysis is one of the reasons for poor production of recombinant proteins in Escherichia coli. Important properties of E. coli proteases, which...
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Mammalian Semiochemicals
Progress that has been made in research on the chemical aspects of mammalian semiochemistry over the past decade is discussed on the basis of...
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DNA Major Groove Binders: Triple Helix-Forming Oligonucleotides, Triple Helix-Specific DNA Ligands and Cleaving Agents
Nucleic acids are polymorphic macromolecules that can adopt a variety of single-, double- and multi-stranded conformations, which in turn may provide...
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The Chemistry of Phosphinous Amides (Aminophosphanes): Old Reagents with New Applications
This chapter is devoted to phosphinous amides, a particular class of tervalent aminophosphanes. First, attention is focused on their stability and...
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Expanding the Analogy Between P=C and C=C Bonds to Polymer Science
Many similarities between the chemistry of carbon and phosphorus in low coordination numbers (i.e., CN=1 or 2) have been established. In particular,...
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Structural Selectivity of Drug-Nucleic Acid Interactions Probed by Competition Dialysis
Competition dialysis is a powerful new tool for the discovery of ligands that bind to nucleic acids with structural- or sequence-selectivity. The...
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Anion Receptors Based on Calixarenes
Calix[n]arenes represent a well-known family of macrocyclic molecules with a broad range of potential applications in many branches of supramolecular...
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DNA Adsorption on Carbonaceous Materials
The immobilization of DNA on different solid supports has become an important issue in different fields ranging from medicine to analytical...
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DNA Immobilization: Silanized Nucleic Acids and Nanoprinting
Over the last decade, the development of DNA microarray technology has allowed the simultaneous analysis of many thousands of different genes in...
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Organic Esters of Cellulose: New Perspectives for Old Polymers
The impetus for the increased interest in the synthesis of functionalized natural polymers, in particular esters of cellulose, is their easy...
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Stochastic “Mirror Symmetry Breaking” via Self-Assembly, Reactivity and Amplification of Chirality: Relevance to Abiotic Conditions
Theories of prebiotic life suggest that homochirality emerged in Nature in abiotic times via deterministic or chance scenarios. This chapter deals...
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The Application of Multi-Parameter Flow Cytometry to Monitor Individual Microbial Cell Physiological State
The development of multi-parameter flow cytometric techniques in our laboratories has led to a functional classification of the physiological state...
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Development of Culture Techniques of Keratinocytes for Skin Graft Production
The in vitro cultures of human tissues have attracted a great deal of medical attention as a promising technique for repairing defective tissues in...
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Large-Scale Micropropagation System of Plant Cells
Plant micropropagation is an efficient method of propagating disease-free, genetically uniform and massive amounts of plants in vitro. The scale-up...
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Studies of Excess Electron and Hole Transfer in DNA at Low Temperatures
In this review investigations of hole and electron transfer processes in DNA after γ-irradiation at low temperatures are described. These experiments...
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Charge Transport in DNA-Based Devices
Charge migration along DNA molecules has attracted scientific interest for over half a century. Reports on possible high rates of charge transfer...