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Functional Magnetic Particles for Medical Application
Magnetic particles for medical applications have been developed by many researchers. Since magnetic particles have unique magnetic features not...
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Analysis and Control of Proteolysis of Recombinant Proteins in Escherichia coli
Proteolysis is one of the reasons for poor production of recombinant proteins in Escherichia coli. Important properties of E. coli proteases, which...
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Mammalian Semiochemicals
Progress that has been made in research on the chemical aspects of mammalian semiochemistry over the past decade is discussed on the basis of...
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Novel Genes Involved in Cephalosporin Biosynthesis: The Three-component Isopenicillin N Epimerase System
Cephalosporin is one of the best β-lactam antibiotics, widely used in the treatment of infectious diseases. It is synthesized by Acremonium...
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Marine Pharmacology: Potentialities in the Treatment of Infectious Diseases, Osteoporosis and Alzheimer's Disease
Several molecules isolated from various marine organisms (microorganisms, algae, fungi, invertebrates, and vertebrates) are currently under study...
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Bioprocess Engineering Data on the Cultivation of Marine Prokaryotes and Fungi
The temperature/pressure dependency of marine prokaryotes and fungi, in terms of their growth behaviour as well as their potential to produce new...
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The Application of Multi-Parameter Flow Cytometry to Monitor Individual Microbial Cell Physiological State
The development of multi-parameter flow cytometric techniques in our laboratories has led to a functional classification of the physiological state...
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Development of Culture Techniques of Keratinocytes for Skin Graft Production
The in vitro cultures of human tissues have attracted a great deal of medical attention as a promising technique for repairing defective tissues in...
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Large-Scale Micropropagation System of Plant Cells
Plant micropropagation is an efficient method of propagating disease-free, genetically uniform and massive amounts of plants in vitro. The scale-up...
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Pheromones of True Bugs
The Heteroptera, or true bugs, comprise a large and widely distributed group of sucking insects, with about 38,000 described species, some of which...
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Pheromone Reception
Insects are analytical chemists par excellence. They perceive the world through semiochemicals with inordinate sensitivity. A male moth, for example,...
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Regulation of Cephalosporin Biosynthesis
The filamentous fungus Acremonium chrysogenum is the natural producer of the β-lactam antibiotic cephalosporin C and is as such used worldwide in...
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Control of Fluxes Towards Antibiotics and the Role of Primary Metabolism in Production of Antibiotics
Yield improvements in antibiotic-producing strains have classically been obtained through random mutagenesis and screening. An attractive alternative...
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Adeno-associated Virus as a Gene Therapy Vector: Vector Development, Production and Clinical Applications
Adeno-associated virus (AAV) has emerged as an attractive vector for gene therapy. AAV vectors have successfully been utilized to promote...
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Lentiviral Vectors
We review the use of lentiviral vectors in current human gene therapy applications that involve genetic modification of nondividing tissues with...
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Plasmid Vaccines and Therapeutics: From Design to Applications
In the late 1980s, Vical and collaborators discovered that the injection into tissues of unformulated plasmid encoding various proteins resulted in...
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Extreme Environments as a Resource for Microorganisms and Novel Biocatalysts
The steady increase in the number of newly isolated extremophilic microorganisms and the discovery of their enzymes by academic and industrial...
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Downstream Processing in Marine Biotechnology
Downstream processing is one of the most underestimated steps in bioprocesses and this is not only the case in marine biotechnology. However, it...
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Asymmetric Total Synthesis of Complex Marine Natural Products
Among nature's ecosystems, the marine environment has been an extremely rich source of structurally complex and biologically active molecules. This...
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Large-Scale Production of Hairy Root
Many products of interest are synthesized in organized tissues, but not formed in suspension or callus culture. Therefore, most attention has been...