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Vitamin D receptor rs3782905 and vitamin D binding protein rs7041 polymorphisms are associated with hepatocellular carcinoma susceptibility in cirrhotic HCV patients
BackgroundThe severity of chronic hepatitis C and susceptibility to hepatocellular carcinoma (HCC) are associated with genetic variations within...
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Biochemical markers and FokI and TaqI vitamin D receptor genes polymorphism in rheumatoid arthritis
BackgroundPrevious studies have reported the role of genes in different metabolic processes in the human body, and any variation in gene...
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Relationship between the thrombospondin-1/Toll-like receptor 4 (TSP1/TLR4) pathway and vitamin D levels in obese and normal weight subjects with different metabolic phenotypes
Thrombospondin-1 (TSP1) contributes to obesity-associated inflammation via activating Toll-like receptor 4 (TLR4). The regulatory role of vitamin D...
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Vitamin D receptor gene polymorphism and polycystic ovary syndrome susceptibility
BackgroundPolycystic ovary syndrome (PCOS) is the most common endocrinopathy in women. This study was designed to investigate the associations of...
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The role of vitamin D receptor in predentin mineralization and dental repair after injury
Dentin is a permeable and complex tubular composite formed by the mineralization of predentin that mineralization and repair are of considerable...
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Vitamin D and Gut Health
Vitamin D is a conditionally required nutrient that can either be obtained from skin synthesis following UVB exposure from the diet. Once in the...
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Vitamin D receptor upregulates tight junction protein claudin-5 against colitis-associated tumorigenesis
Tight junctions are essential for barrier integrity, inflammation, and cancer. Vitamin D and the vitamin D receptor (VDR) play important roles in...
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Emerging perspectives: unraveling the anticancer potential of vitamin D3
Vitamin D 3 , a fat-soluble vitamin known for its critical function in calcium homeostasis and bone health, is gaining interest for its anticancer...
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The Role of Vitamin D As a Biomarker in Trauma
Vitamin D is a collective term for two main forms of hormonal sterols that form a shared active metabolite, calcitriol. While it is essential for...
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Vitamin D receptor gene polymorphisms are associated with the risk and features of myasthenia gravis in the Han Chinese population
Vitamin D receptor gene (VDR) polymorphisms are candidate genetic variants for susceptibility to autoimmune diseases. Here, we explored the...
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Significance of the Vitamin D Receptor on Crosstalk with Nuclear Receptors and Regulation of Enzymes and Transporters
The vitamin D receptor (VDR), in addition to other nuclear receptors, the pregnane X receptor (PXR) and constitutive androstane receptor (CAR), is...
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Vitamin D ameliorates age-induced nonalcoholic fatty liver disease by increasing the mitochondrial contact site and cristae organizing system (MICOS) 60 level
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease. Despite intensive research, considerable information on NAFLD development...
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Role of Neural Stem Cells and Vitamin D Receptor (VDR)–Mediated Cellular Signaling in the Mitigation of Neurological Diseases
Specific stem cell–based therapies for treating Alzheimer’s disease, Parkinson’s disease, and schizophrenia are gaining importance in recent years....
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Variation in the vitamin D receptor gene, plasma 25-hydroxyvitamin D, and risk of premenstrual symptoms
BackgroundVitamin D status has been associated with the presence and severity of several premenstrual symptoms (PMSx) in some, but not all studies....
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Vitamin D Receptor and Binding Protein Gene Variants in Patients with Essential Tremor
Several studies have shown an association between some variants in the vitamin D receptor ( VDR ) and the GC vitamin D binding protein ( GC ) genes with...
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Vitamin D receptor (VDR) mediates the quiescence of activated hepatic stellate cells (aHSCs) by regulating M2 macrophage exosomal smooth muscle cell-associated protein 5 (SMAP-5)
An effective therapeutic regimen for hepatic fibrosis requires a deep understanding of the pathogenesis mechanism. Hepatic fibrosis is characterized...
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Association of Genotypes of ANGPTL3 with Vitamin D and Calcium Concentration in Cardiovascular Disease
One of the leading causes of mortality worldwide is cardiovascular disease, which is influenced by some variables, including calcium and vitamin D....
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Potential interplay between tumor size and vitamin D receptor (VDR) polymorphisms in breast cancer prognosis: a prospective cohort study
PurposeVitamin D has some anticancer properties that may decrease breast cancer risk and improve prognosis. The aim was to investigate associations...
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Does vitamin D protect or treat Parkinson’s disease? A narrative review
Parkinson’s disease (PD) is a neurodegenerative brain disease (NBD) developed due to dopaminergic neuron loss in the substantia nigra (SN). Vitamin D...
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Neuroinflammation in Alzheimer’s disease: potential beneficial effects of vitamin D
Alzheimer’s disease (AD) is the most common cause of dementia. In recent years, several studies have robustly shown that neuroinflammation plays a...
