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Carcinoma of unknown primary (CUP): an update for histopathologists
Carcinoma of unknown primary (CUP) is a heterogeneous group of metastatic cancers in which the site of origin is not identifiable. These carcinomas...
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Radiation-response in primary fibroblasts of long-term survivors of childhood cancer with and without second primary neoplasms: the KiKme study
BackgroundThe etiology and most risk factors for a sporadic first primary neoplasm in childhood or subsequent second primary neoplasms are still...
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Comprehensive analysis of cancer of unknown primary and recommendation of a histological and immunohistochemical diagnostic strategy from China
BackgroundPrevious studies on cancer of unknown primary (CUP) mainly focus on treatment and prognosis in western populations and lacked clinical...
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Risk factors for cancer of unknown primary: a literature review
Cancer of Unknown Primary (CUP) is metastatic cancer with an unidentifiable primary tumour origin during life. It remains difficult to study the...
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Validation of a Transcriptome-Based Assay for Classifying Cancers of Unknown Primary Origin
IntroductionCancers assume a variety of distinct histologies, and may originate from a myriad of sites including solid organs, hematopoietic cells,...
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Subsequent primary neoplasms after childhood cancer therapy – design and description of the German nested case–control study STATT-SCAR
BackgroundSubsequent primary neoplasms (SPN) are among the most severe late effects and the second most frequent cause of death in childhood cancer...
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Tissue of origin prediction for cancer of unknown primary using a targeted methylation sequencing panel
RationaleCancer of unknown primary (CUP) is a group of rare malignancies with poor prognosis and unidentifiable tissue-of-origin. Distinct DNA...
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Phase II study of everolimus and temozolomide as first-line treatment in metastatic high-grade gastroenteropancreatic neuroendocrine neoplasms
BackgroundThe optimal treatment for metastatic high-grade gastroenteropancreatic (GEP) neuroendocrine neoplasms when Ki-67 ≤55% is unknown. A...
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Targeting PP2A-dependent autophagy enhances sensitivity to ruxolitinib in JAK2V617F myeloproliferative neoplasms
The Janus kinase 2 (JAK2)-driven myeloproliferative neoplasms (MPNs) are chronic malignancies associated with high-risk complications and suboptimal...
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Adoptive cellular immunotherapy for solid neoplasms beyond CAR-T
In recent decades, immune checkpoint blockade and chimeric antigen receptor T cell (CAR-T) therapy are two milestone achievements in clinical...
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Oligo-metastatic neoPlasms from the gastro-intestinal tract: iDentIfiCaTIon of cliNical and molecular drivers: the PREDICTION study
BackgroundMetastatic disease in tumors originating from the gastrointestinal tract can exhibit varying degrees of tumor burden at presentation. Some...
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Classical fever of unknown origin in 21 countries with different economic development: an international ID-IRI study
Fever of unknown origin (FUO) is a serious challenge for physicians. The aim of the present study was to consider epidemiology and dynamics of FUO...
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Single-cell transcriptomics dissects the transcriptome alterations of hematopoietic stem cells in myelodysplastic neoplasms
BackgroundMyelodysplastic neoplasms (MDS) are myeloid neoplasms characterized by disordered differentiation of hematopoietic stem cells and a...
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An integrative approach for exploring the nature of fibroepithelial neoplasms
BackgroundMalignant phyllodes tumour (MPT) is a rare breast malignancy with epithelial and mesenchymal features. Currently, there are no appropriate...
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Treatment outcome according to genetic tumour alterations and clinical characteristics in digestive high-grade neuroendocrine neoplasms
BackgroundChemotherapy has limited efficacy in advanced digestive high-grade neuroendocrine neoplasms (HG-NEN) and prognosis is dismal. Predictive...
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Neutrophil-to-lymphocyte ratio and all-cause mortality with and without myeloproliferative neoplasms—a Danish longitudinal study
The neutrophil-to-lymphocyte ratio(NLR) is increased in chronic inflammation and myeloproliferative neoplasms (MPN). We hypothesize that NLR is...
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Identification of functional pathways and molecular signatures in neuroendocrine neoplasms by multi-omics analysis
BackgroundNeuroendocrine neoplasms (NENs) represent a heterogeneous class of rare tumors with increasing incidence. They are characterized by the...
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ALKBH5 enhances lipid metabolism reprogramming by increasing stability of FABP5 to promote pancreatic neuroendocrine neoplasms progression in an m6A-IGF2BP2-dependent manner
The process of post-transcriptional regulation has been recognized to be significantly impacted by the presence of N 6-methyladenosine (m6A)...
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GLP and G9a histone methyltransferases as potential therapeutic targets for lymphoid neoplasms
Histone methyltransferases (HMTs) are enzymes that regulate histone methylation and play an important role in controlling transcription by altering...
