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Recent advances in cancer-on-a-chip tissue models to dissect the tumour microenvironment
Three-dimensional cancer-on-a-chip tissue models aim to replicate the key hallmarks of the tumour microenvironment and allow for the study of dynamic...
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Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment
The development of neoplasia involves a complex and continuous interplay between malignantly transformed cells and the tumour microenvironment (TME)....
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How chemokines organize the tumour microenvironment
For our immune system to contain or eliminate malignant solid tumours, both myeloid and lymphoid haematopoietic cells must not only extravasate from...
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Remodelling of the tumour microenvironment by the kallikrein-related peptidases
Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment. KLKs are proteolytic enzymes regulating multiple...
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The role of three-dimensional in vitro models in modelling the inflammatory microenvironment associated with obesity in breast cancer
Obesity is an established risk factor for breast cancer in postmenopausal women. However, the underlying biological mechanisms of how obesity...
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Highlight: microfluidic devices for cancer metastasis studies
Whilst cancer is the single most researched disease by number of clinical trials, it remains a leading cause of death in middle- to high-income...
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Adipocytes in the Tumour Microenvironment
Adipose tissue contribution to body mass ranges from 6% in male athletes to over 25% in obese men and over 30% in obese women. Crosstalk between...
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Applications of Microfluidics in Cancer Diagnosis and Treatment
Cancer is one of the leading causes of mortality globally, with a possibility to prevent many of these incidents via enhancing lifestyle habits and...
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3D bioprinted cancer models: from basic biology to drug development
Effort invested in the development of new drugs often fails to be translated into meaningful clinical benefits for patients with cancer. The...
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Beta-blocker adjunct therapy as a prospective anti-metastatic with cardio-oncologic regulation
The prevailing treatment stratagem in cancer therapy still challenges the dilemma of a probable metastatic spread following an initial diagnosis....
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A multi-layered hybrid model for cancer cell invasion
In this article, a hybrid model is developed based on multi-scale concept for solid tumour cell invasion into a healthy tissue. Our aim is to study...
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Cancer stem cell-derived CHI3L1 activates the MAF/CTLA4 signaling pathway to promote immune escape in triple-negative breast cancer
BackgroundTriple-negative breast cancer (TNBC) development may be associated with tumor immune escape. This study explores whether the...
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A roadmap for translational cancer glycoimmunology at single cell resolution
Cancer cells can evade immune responses by exploiting inhibitory immune checkpoints. Immune checkpoint inhibitor (ICI) therapies based on anti-CTLA-4...
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The pro-tumorigenic host response to cancer therapies
Resistance to cancer therapy remains a major challenge in clinical oncology. Although the initial treatment phase is often successful, eventual...
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Current and Emerging 3D Models to Study Breast Cancer
For decades 2D culture has been used to study breast cancer. In recent years, however, the importance of 3D culture to recapitulate the complexity of...
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The Role of the Neuropilins in Tumour Angiogenesis and Tumour Progression
Neuropilins (NRPs) are multifunctional receptors for class 3 semaphorins, which are responsible for axon guidance during the development of the...
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The Tumor Microenvironments of Lethal Prostate Cancer
Localized prostate cancer (confined to the gland) generally is considered curable, with nearly a 100% 5-year-survival rate. When the tumor escapes...
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Modelomics to Investigate Cancer Bone Metastasis
Purpose of reviewModelomics approach allows modelling and understanding of the mechanisms regulating living complex systems using computational and...
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TAMeless traitors: macrophages in cancer progression and metastasis
Macrophages are conventionally classified into M1 and M2 subtypes according to their differentiation status and functional role in the immune system....
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Tumor Angiogenesis
In 1907, Goldman described the characteristics of tumor vessels including their dilatation, accelerated proliferation and irregular arrangement. In...