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Cancer Stem Cell Markers in Haematological Malignancies
Cancer stem cells (CSCs) are a subgroup of tumour cells with tumorigenic potential due to their ability to transform into tumours through...
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Multiplex protein imaging in tumour biology
Tissue imaging has become much more colourful in the past decade. Advances in both experimental and analytical methods now make it possible to image...
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Tumour-derived small extracellular vesicles contribute to the tumour progression through resha** the systemic immune macroenvironment
BackgroundTumour-derived small extracellular vesicles (sEVs) play a crucial role in cancer immunomodulation. In addition to tumour immune...
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Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager
The broader clinical use of bispecific T cell engagers for inducing anti-tumour toxicity is hindered by their on-target off-tumour toxicity and the...
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Understanding tumour endothelial cell heterogeneity and function from single-cell omics
Anti-angiogenic therapies (AATs) are used to treat different types of cancers. However, their success is limited owing to insufficient efficacy and...
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Identification of mutation patterns and circulating tumour DNA-derived prognostic markers in advanced breast cancer patients
BackgroundThe correlations between circulating tumour DNA (ctDNA)-derived genomic markers and treatment response and survival outcome in Chinese...
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Characteristics of vasculogenic mimicry and tumour to endothelial transdifferentiation in human glioblastoma: a systematic review
BackgroundGlioblastoma, the most common primary malignant brain tumour in adults, is a highly vascular tumour characterised by abnormal angiogenesis....
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Circulating Tumour Cell Isolation and Molecular Profiling; Potential Therapeutic Intervention
Comprehensive tumour characterisation is indispensable for patients to receive targeted therapy. The use of liquid biopsy, particularly circulating...
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Loss of two-pore channel 2 function in melanoma-derived tumours reduces tumour growth in vivo but greatly increases tumour-related toxicity in the organism
BackgroundMelanoma, a severe form of skin cancer, poses significant health risks due to its aggressive nature and potential for metastasis. The role...
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Resha** the tumour immune microenvironment in solid tumours via tumour cell and immune cell DNA methylation: from mechanisms to therapeutics
In recent years, the tumour microenvironment (TME) of solid tumours has attracted more and more attention from researchers, especially those...
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Tumour-on-a-Chip: Perfusion Systems to Model the Extracellular Breast Tumour Microenvironment—From Tumour Progression to Metastasis Formation
The integration of three-dimensional (3D) tumour models in perfusion systems has provided new tools to study cancer and metastasis. Such systems are...
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TRPV1 inhibition suppresses non-small cell lung cancer progression by inhibiting tumour growth and enhancing the immune response
PurposeTRPV1 is a nonselective Ca 2+ channel protein that is widely expressed and plays an important role during the occurrence and development of...
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The tumour microenvironment, treatment resistance and recurrence in glioblastoma
The adaptability of glioblastoma (GBM) cells, encouraged by complex interactions with the tumour microenvironment (TME), currently renders GBM an...
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Severely polarized extracellular acidity around tumour cells
Extracellular pH impacts many molecular, cellular and physiological processes, and hence is tightly regulated. Yet, in tumours, dysregulated cancer...
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Cancer organoids 2.0: modelling the complexity of the tumour immune microenvironment
The development of neoplasia involves a complex and continuous interplay between malignantly transformed cells and the tumour microenvironment (TME)....
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A cell cycle centric view of tumour dormancy
Tumour dormancy and recurrent metastatic cancer remain the greatest clinical challenge for cancer patients. Dormant tumour cells can evade treatment...
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Integrated circulating tumour DNA and cytokine analysis for therapy monitoring of ALK-rearranged lung adenocarcinoma
BackgroundDetection of circulating tumour DNA (ctDNA) in biological fluids is a minimally invasive alternative to tissue biopsy for therapy...
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Therapeutic targeting of tumour myeloid cells
Myeloid cells are pivotal within the immunosuppressive tumour microenvironment. The accumulation of tumour-modified myeloid cells derived from...
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Single-cell sequencing of PIT1-positive pituitary adenoma highlights the pro-tumour microenvironment mediated by IFN-γ-induced tumour-associated fibroblasts remodelling
BackgroundPIT1-positive pituitary adenoma (PIT1-PA) is one of the most important lineages of pituitary adenoma (PA), which causes systematic...
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The Heterogeneity of Tumour-Associated Macrophages Contributes to the Recurrence and Outcomes of Glioblastoma Patients
Cellular heterogeneity and immune cell molecular phenotypes may be involved in the malignant progression of glioblastoma (GBM). In this study, we...
