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A new childhood ALL case with an extremely complex karyotype and acute spontaneous tumor lysis syndrome
BackgroundB cell precursor acute lymphoblastic leukemia (B-ALL) is the most common malignancy of childhood, with, after corresponding treatment, an...
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Tumor Immunology and Immunotherapy
Understanding immune mechanisms in cancer and immunotherapy has made cancer diagnosis and treatment more effective. The immune system can recognize...
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Bortezomib administration is a risk factor associated with the development of tumor lysis syndrome in male patients with multiple myeloma: a retrospective study
BackgroundNovel agents such as proteasome inhibitors have been developed for several years to treat multiple myeloma. Although multiple myeloma is a...
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Tumor-on-a-Chip: Microfluidic Models of Hypoxic Tumor Microenvironment
Cancer is ranked as the deadliest prime health issue, albeit with mammoth efforts to panacea the ailment. To subdue the vast constraints in tumor...
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Tumor Lysis Syndrome
Tumor lysis syndrome refers to the laboratory and clinical results of rapid breakdown of high volumes of malignant cells. Significant electrolyte...
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Mouse Models of Obesity to Study the Tumor-Immune Microenvironment
Obesity is associated with chronic, low-grade systemic inflammation and leads to changes in the immune microenvironment of various tissues. As a...
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The golden key to open mystery boxes of SMARCA4-deficient undifferentiated thoracic tumor: focusing immunotherapy, tumor microenvironment and epigenetic regulation
SMARCA4-deficient undifferentiated thoracic tumor is extremely invasive. This tumor with poor prognosis is easily confused with SMARCA4-deficent...
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PD-1-CD28 fusion protein strengthens mesothelin-specific TRuC T cells in preclinical solid tumor models
BackgroundT cell receptor fusion constructs (TRuC) consist of an antibody-based single chain variable fragment (scFv) fused to a T cell receptor...
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A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity
BackgroundOsteosarcoma (OS) is one of most commonly diagnosed bone cancer. Circular RNAs (circRNAs) are a class of highly stable non-coding RNA, the...
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The crosstalk between immune cells and tumor pyroptosis: advancing cancer immunotherapy strategies
Pyroptosis is a cell death process characterized by cell swelling until membrane rupture and release of intracellular contents. As an effective tumor...
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The interaction between DNA methylation and tumor immune microenvironment: from the laboratory to clinical applications
DNA methylation is a pivotal epigenetic modification that affects gene expression. Tumor immune microenvironment (TIME) comprises diverse immune...
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Application of the PGT-M strategy using single sperm and/or affected embryos as probands for linkage analysis in males with hereditary tumor syndromes without family history
Hereditary tumor syndromes have garnered substantial attention due to their adverse effects on both the physical and psychological health of...
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The opposing effect of acute and chronic Toxoplasma gondii infection on tumor development
BackgroundThe interplay between Toxoplasma gondii infection and tumor development is intriguing and not yet fully understood. Some studies showed...
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The Role of Tumor Microenvironment in Colon Cancer
Colorectal cancer (CRC) is one of the most common causes of morbidity and mortality in both women and men. Given that CRC is an important health...
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Advances in metabolic reprogramming of NK cells in the tumor microenvironment on the impact of NK therapy
Natural killer (NK) cells are unique from other immune cells in that they can rapidly kill multiple neighboring cells without the need for antigenic...
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Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer
BackgroundChimeric antigen receptor (CAR) -T cell therapy is an efficient therapeutic strategy for specific hematologic malignancies. However,...
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Current state-of-the-art on ganglioside-mediated immune modulation in the tumor microenvironment
Gangliosides are sialylated glycolipids, mainly present at the cell surface membrane, involved in a variety of cellular signaling events. During...
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Advances in tumor nanotechnology: theragnostic implications in tumors via targeting regulated cell death
Cell death constitutes an indispensable part of the organismal balance in the human body. Generally, cell death includes regulated cell death (RCD)...
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miR-29a-SIRT1-Wnt/β-Catenin Axis Regulates Tumor Progression and Survival in Hepatocellular Carcinoma
Sirtuin 1 (SIRT1) participates in the initiation and evolution of hepatocellular carcinoma (HCC). However, the specific mechanism of SIRT1 in HCC...
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Role of myeloid-derived suppressor cells in tumor recurrence
The establishment of primary tumor cells in distant organs, termed metastasis, is the principal cause of cancer mortality and is a crucial...
