Search
Search Results
-
Increased cysteinyl-tRNA synthetase drives neuroinflammation in Alzheimer’s disease
BackgroundMicroglia-mediated neuroinflammation in Alzheimer’s disease (AD) is not only a response to pathophysiological events, but also plays a...
-
Unique roles of tryptophanyl-tRNA synthetase in immune control and its therapeutic implications
Tryptophanyl tRNA synthetase (WRS) is an essential enzyme as it catalyzes the ligation of tryptophan to its cognate tRNA during translation....
-
Transfer RNAs as dynamic and critical regulators of cancer progression
Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode the genetic code into proteins. Recent work has uncovered...
-
Mitochondrial aminoacyl-tRNA synthetase disorders: an emerging group of developmental disorders of myelination
BackgroundThe mitochondrial aminoacyl-tRNA synthetase proteins (mt-aaRSs) are a group of nuclear-encoded enzymes that facilitate conjugation of each...
-
tRNA therapeutics for genetic diseases
Transfer RNAs (tRNAs) have a crucial role in protein synthesis, and in recent years, their therapeutic potential for the treatment of genetic...
-
Stress and Kynurenine-Inflammation Pathway in Major Depressive Disorder
Major depressive disorder (MDD) is one of the most prevalent disorders and causes severe damage to people’s quality of life. Lifelong stress is one...
-
Mitochondrial Translation Deficiencies
Most mitochondrial diseases are disabling and progressive, usually affecting multiple organs with high energy demand such as the brain, liver,...
-
Whole‐exome sequencing of a Saudi epilepsy cohort reveals association signals in known and potentially novel loci
BackgroundEpilepsy, a serious chronic neurological condition effecting up to 100 million people globally, has clear genetic underpinnings including...
-
Clinical genetics of Charcot–Marie–Tooth disease
Recent research in the field of inherited peripheral neuropathies (IPNs) such as Charcot–Marie–Tooth (CMT) disease has helped identify the causative...
-
Cellular receptors for enterovirus A71
Enterovirus 71 (EV-A71) is one of the major causative agents of hand, foot, and mouth disease. EV-A71 infection is sometimes associated with severe...
-
Functional and pathologic association of aminoacyl-tRNA synthetases with cancer
Although key tumorigenic and tumor-suppressive factors have been unveiled over the last several decades, cancer remains the most life-threatening...
-
-
Tryptophan catabolism via the kynurenine pathway regulates infection and inflammation: from mechanisms to biomarkers and therapies
Backgroundl -Tryptophan ( l -Trp), an essential amino acid, is the only amino acid whose level is regulated specifically by immune signals. Most...
-
Cancer immunometabolism: advent, challenges, and perspective
For decades, great strides have been made in the field of immunometabolism. A plethora of evidence ranging from basic mechanisms to clinical...
-
Combined the SMAC mimetic and BCL2 inhibitor sensitizes neoadjuvant chemotherapy by targeting necrosome complexes in tyrosine aminoacyl-tRNA synthase-positive breast cancer
BackgroundChemotherapy is the standard treatment for breast cancer; however, the response to chemotherapy is disappointingly low. Here, we...
-
Reprogramming the genetic code
The encoded biosynthesis of proteins provides the ultimate paradigm for high-fidelity synthesis of long polymers of defined sequence and composition,...
-
An In-depth Proteomic Map of Leishmania donovani Isolate from Post Kala-azar Dermal Leishmaniasis (PKDL) Patient
BackgroundThe trypanosomatid protozoan parasite Leishmania donovani is the etiological agent of visceral leishmaniasis (VL) or kala-azar. The...
-
Nanotheranostics: The Afterglow for Cancer Immunotherapy
Cancer immunotherapy is on its advent. However, some drawbacks seem to limit its application, namely, the immune-related adverse events and the...
-
Aminoacyl tRNA synthetases as potential drug targets of the Panthera pathogen Babesia
BackgroundA century ago, pantheras were abundant across Asia. Illegal hunting and trading along with loss of habitat have resulted in the designation...
-
Recent metabolomic developments for antimalarial drug discovery
Malaria is a parasitic disease that remains a global health issue, responsible for a significant death and morbidity toll. Various factors have...
