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Single-cell profiling of response to neoadjuvant chemo-immunotherapy in surgically resectable esophageal squamous cell carcinoma
BackgroundThe efficacy of neoadjuvant chemo-immunotherapy (NAT) in esophageal squamous cell carcinoma (ESCC) is challenged by the intricate interplay...
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Evaluating atezolizumab in patients with urinary tract squamous cell carcinoma (AURORA): study protocol for a single arm, open-label, multicentre, phase II clinical trial
BackgroundBladder and urinary tract cancers account for approximately 21,000 new diagnoses and 5,000 deaths annually in the UK. Approximately 90% are...
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Novel imino-thiazoloquinoxaline derivatives against renal cell carcinoma: less radiation-damaging approach
Renal cell carcinoma (RCC) is the most fatal tumor in the urinary system. Resistance development and unmet effective responses, request new...
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THOC7-AS1/OCT1/FSTL1 axis promotes EMT and serves as a therapeutic target in cutaneous squamous cell carcinoma
BackgroundTHOC7-AS1 and FSTL1 expression are frequently upregulated in cutaneous squamous cell carcinoma (cSCC). However, their molecular biological...
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Tumor specificity of WNT ligands and receptors reveals universal squamous cell carcinoma oncogenes
BackgroundThe WNT signal pathway has myriad family members, which are broadly involved in embryonic development and human cancer. Over-activation of...
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A novel upregulated hsa_circ_0032746 regulates the oncogenesis of esophageal squamous cell carcinoma by regulating miR-4270/MCM3 axis
IntroductionCircular RNAs (CircRNA) have emerged as an interest of research in recent years due to its regulatory role in various kinds of cancers of...
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TUBA1C is a potential new prognostic biomarker and promotes bladder urothelial carcinoma progression by regulating the cell cycle
BackgroundTUBA1C is an α-tubulin isoform involved in mitosis, and its dysregulation has been implicated in tumor progression. There is still no clear...
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HLA-A+ tertiary lymphoid structures with reactivated tumor infiltrating lymphocytes are associated with a positive immunotherapy response in esophageal squamous cell carcinoma
BackgroundImmune checkpoint blockade (ICB) therapy provides remarkable clinical benefits for multiple cancer types. However, the overall response...
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Analysis of ICAM-1 Expression on Bladder Carcinoma Cell Lines and Infectivity and Oncolysis by Coxsackie Virus A21
Oncolytic viruses are biological agents which can easily be delivered at high doses directly to the bladder through a catheter (intravesical), with...
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Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis
BackgroundRecent studies using single-cell transcriptomic analysis have reported several distinct clusters of neoplastic epithelial cells and...
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Decoding meningioma heterogeneity and neoplastic cell—macrophage interaction through single-cell transcriptome profiling across pathological grades
BackgroundAnalyzing meningioma of distinct pathological types at the single-cell level can provide new and valuable insights into the specific...
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Feasibility of mass cytometry proteomic characterisation of circulating tumour cells in head and neck squamous cell carcinoma for deep phenoty**
BackgroundCirculating tumour cells (CTCs) are a potential cancer biomarker, but current methods of CTC analysis at single-cell resolution are...
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Single cell atlas of kidney cancer endothelial cells reveals distinct expression profiles and phenotypes
BackgroundTumor endothelial cells (TECs) represent the primary interface between the tumor microenvironment and circulating immune cells, however...
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Establishment of anti-DKK3 peptide for the cancer control in head and neck squamous cell carcinoma (HNSCC)
BackgroundHead and neck squamous cell carcinoma (HNSCC) is the most common malignant tumor of the head and neck. We identified cancer-specific genes...
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Ubiquitous Merkel Cell Polyomavirus: Causative Agent of the Rare Merkel Cell Carcinoma
Merkel Cell polyomavirus (MCPyV) isMerkel Cell polyomavirus (MCPyV) the only member of the Polyomaviridae family that is directly linked to a type of...
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Novel Therapeutics Targeting Cancer Stem Cell Surface Markers
Cancer stem cells (CSCs) are a subpopulation of undifferentiated cells possessing the ability of self-renewal and differentiation into non-CSCs...
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Integrating HECW1 expression into the clinical indicators exhibits high accuracy in assessing the prognosis of patients with clear cell renal cell carcinoma
BackgroundAlthough many intratumoral biomarkers have been reported to predict clear cell renal cell carcinoma (ccRCC) patient prognosis, combining...
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T-Cell Exhaustion in Cancers
There are different concepts that relate to T-cell hyporesponsivity, such as ignorance, tolerance, anergy, aging, and exhaustion. Among these, T-cell...
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Squamous cell carcinoma of the renal pelvis in a patient with long-term spinal cord injury—a case report
IntroductionFor individuals with spinal cord injury/disease (SCI/D) the risk of develo** a stone in the upper urinary tract is up to six times...
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Carcinoma of unknown primary (CUP): an update for histopathologists
Carcinoma of unknown primary (CUP) is a heterogeneous group of metastatic cancers in which the site of origin is not identifiable. These carcinomas...
