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Origin of thyrotropin-releasing hormone neurons that innervate the tuberomammillary nuclei
Hypophysiotropic thyrotropin-releasing hormone (TRH) neurons function as metabolic sensors that regulate the thyroid axis and energy homeostasis....
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Cardiovascular and body weight regulation changes in transgenic mice overexpressing thyrotropin-releasing hormone (TRH)
Thyrotropin-releasing hormone (TRH) plays several roles as a hormone/neuropeptide. Diencephalic TRH (dTRH) participates in the regulation of blood...
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Multifactorial Regulation of the Activity of Hypophysiotropic Thyrotropin-Releasing Hormone Neurons
Hypophysiotropic neurons of the paraventricular nucleus of the hypothalamus that express thyrotropin-releasing hormone (TRH) control the synthesis... -
Thyrotropin-releasing hormone axonal varicosities appear to innervate dopaminergic neurons in the human hypothalamus
Thyrotropin-releasing hormone (TRH) has a critical role in the central regulation of thyroid-stimulating hormone (TSH) from the anterior pituitary,...
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Tanycyte Regulation of Hypophysiotropic TRH Neurons
Tanycytes lining the third ventricle are emerging as an integral component of the hypothalamic regulatory system. Their functions, including the... -
Rifaximin modulates TRH and TRH-like peptide expression throughout the brain and peripheral tissues of male rats
BackgroundThe TRH/TRH-R1 receptor signaling pathway within the neurons of the dorsal vagal complex is an important mediator of the brain-gut axis....
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Individual Features of the Hypothalamic—Pituitary—Thyroid Axis Functioning during Aging in Non-Human Primates
Individual features of age-related changes in the function of the neuroendocrine systems are an important problem as the basic component of a...
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Pembrolizumab-induced secondary adrenal insufficiency due to adrenocorticotrophic hormone deficiency in a patient with non-small-cell lung carcinoma: a case report
BackgroundPembrolizumab can cause immune-related adverse events such as adrenal insufficiency (AI). However, there is no consensus regarding...
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The Study of Biological Activity of a New Thieno[2,3-D]-Pyrimidine-Based Neutral Antagonist of Thyrotropin Receptor
The development of low-molecular-weight antagonists of thyroid-stimulating hormone (TSH) receptor is a promising trend in the treatment of autoimmune...
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Molecular evidence reveals thyrotropin intervention enhances the risk of develo** radioiodine-refractory differentiated thyroid carcinoma
Radioiodine (RAI) is the mainstay of treatment for differentiated thyroid carcinoma (DTC) following total thyroidectomy. Nevertheless, about 5% of...
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Lactation and the Control of the Prolactin Secretion
Prolactin is a polypeptide hormone secreted from the lactotrophs in the anterior pituitary gland. It is recognized as a pleiotropic hormone with... -
Hypothalamic-Pituitary-End-Organ Axes: Hormone Function in Female Patients with Major Depressive Disorder
Classic hypothalamic-pituitary-end-organ feedback loops – the hypothalamic-pituitary-adrenal axis (HPAA), hypothalamic-pituitary-thyroidal axis...
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Dynamics of Prolactin and Hormones of the Hypothalamic-Pituitary Thyroid Axis in Patients with Schizophrenia
Abstract —In 70 examined patients, 34 with the first psychotic episode (FPE) and 36 with chronic schizophrenia (CS), we studied dynamics of the...
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Melanin-Concentrating Hormone, Neuropeptide E-I, and MCH Receptor 1
Melanin-concentrating hormone (MCH) and neuropeptide E-I (NEI) are neuropeptides produced from the pro-melanin-concentrating hormone gene, which are... -
Endocrine Disorders
This chapter discusses the links between hormonal disorders and cerebellar symptoms. Cerebellar development depends on thyroid hormone (TH) which... -
Cardiovascular Neuroendocrinology of Pregnancy
Neuroendocrine hormones are released primarily from the anterior and posterior pituitary, under the influence of hypothalamic input, to maintain... -
Mechanisms of Homeostatically Regulated Behaviors
Homeostasis is broadly defined as the maintenance of internal physiological conditions in the face of altered environmental conditions. Conditions... -
Endocrine Disorders
Cerebellum is vulnerable to hormonal disturbances. The main endocrine disorders associated with cerebellar ataxia are thyroid diseases. Both... -
A method for predicting drugs that can boost the efficacy of immune checkpoint blockade
Combination therapy is a promising therapeutic strategy to enhance the efficacy of immune checkpoint blockade (ICB); however, predicting drugs for...
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Lectures 9 and 10: Endocrine System & Hormones
The Endocrine System consists the following organs: Hypothalamus, pituitary (anterior & posterior parts), pineal, thyroid, 4 parathyroids, thymus,...